Eef2kmt eukaryotic elongation factor 2 lysine methyltransferase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Eef2kmtprovided by MGI
Official Full Name: eukaryotic elongation factor 2 lysine methyltransferaseprovided by MGI
Primary source: MGI:MGI:1917761
See related: Ensembl:ENSMUSG00000022544 AllianceGenome:MGI:1917761
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fam86; Fam86a; eEF2-KMT; 5730409G15Rik
Summary: Predicted to enable protein-lysine N-methyltransferase activity. Predicted to act upstream of or within methylation. Predicted to be located in cytoplasm. Predicted to be part of protein-containing complex. Orthologous to several human genes including EEF2KMT (eukaryotic elongation factor 2 lysine methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in ovary adult (RPKM 25.4), adrenal adult (RPKM 22.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 A1; 16 2.51 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (5062019..5073820, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (5244155..5255956, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3)
Endonuclease-mediated (2)

General gene information

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Homology

Orthologs from Annotation Pipeline: 474 organisms have orthologs with human gene Eef2kmt
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein-lysine N-methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within methylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein-lysine N-methyltransferase EEF2KMT

Names: eEF2-lysine methyltransferase; family with sequence similarity 86; protein FAM86A; putative protein N-methyltransferase FAM86A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027446.2 → NP_081722.1 protein-lysine N-methyltransferase EEF2KMT

See identical proteins and their annotated locations for NP_081722.1

Status: PROVISIONAL

Source sequence(s)

AK133590

Consensus CDS

CCDS27935.1

UniProtKB/Swiss-Prot

Q3UZW7, Q9CS89

Related

ENSMUSP00000068003.6, ENSMUST00000064635.12

Conserved Domains (2) summary

pfam14904
Location:6 → 97

FAM86; Family of unknown function

cl17173
Location:135 → 299

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...