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DLL4 delta like canonical Notch ligand 4 [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 704898, updated on 17-Dec-2025
Official Symbol
DLL4provided by VGNC
Official Full Name
delta like canonical Notch ligand 4provided by VGNC
Primary source
VGNC:VGNC:71926
See related
Ensembl:ENSMMUG00000014541
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
all
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See DLL4 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2025_08 current T2T-MMU8v2.0 (GCF_049350105.2) 7 NC_133412.1 (18294301..18304132)
103 previous assembly Mmul_10 (GCF_003339765.1) 7 NC_041760.1 (17392567..17402397)

Chromosome 7 - NC_133412.1Genomic Context describing neighboring genes Neighboring gene VPS18 core subunit of CORVET and HOPS complexes Neighboring gene uncharacterized LOC144329841 Neighboring gene uncharacterized LOC144329842 Neighboring gene iron-sulfur cluster assembly 1 homolog, mitochondrial pseudogene Neighboring gene ChaC glutathione specific gamma-glutamylcyclotransferase 1

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables Notch binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell communication IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
delta-like protein 4

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RefSeqs of Annotated Genomes: GCF_049350105.2-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference T2T-MMU8v2.0

Genomic

  1. NC_133412.1 Reference T2T-MMU8v2.0

    Range
    18294301..18304132
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001099250.4 → XP_001099250.1  delta-like protein 4

    See identical proteins and their annotated locations for XP_001099250.1

    UniProtKB/TrEMBL
    F7G756
    Related
    ENSMMUP00000019092.3
    Conserved Domains (3) summary
    cd00054
    Location:327 → 360
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam01414
    Location:155 → 217
    DSL; Delta serrate ligand
    pfam07657
    Location:27 → 88
    MNNL; N terminus of Notch ligand
Nucleotide Protein
Heading Accession and Version

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Molecular Biology Databases
Research Materials