U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cenpl centromere protein L [ Mus musculus (house mouse) ]

Gene ID: 70454, updated on 7-Apr-2025

Summary

Go to the top of the page Help
Official Symbol
Cenplprovided by MGI
Official Full Name
centromere protein Lprovided by MGI
Primary source
MGI:MGI:1917704
See related
Ensembl:ENSMUSG00000026708 AllianceGenome:MGI:1917704
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CENP-L; 2610300B10Rik
Summary
Predicted to be involved in chromosome segregation. Predicted to be located in nucleus. Predicted to be part of inner kinetochore. Is expressed in cerebral cortex ventricular layer. Orthologous to human CENPL (centromere protein L). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Biased expression in liver E14 (RPKM 9.0), liver E14.5 (RPKM 6.7) and 11 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Cenpl in Genome Data Viewer
Location:
1 H2.1; 1 69.75 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (160898337..160914294)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (161070767..161086724)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 25789 Neighboring gene growth arrest specific 5 Neighboring gene aspartyl-tRNA synthetase 2 (mitochondrial) Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:163000837-163001115 Neighboring gene STARR-positive B cell enhancer ABC_E11097 Neighboring gene kelch-like 20 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:163061431-163061751 Neighboring gene STARR-seq mESC enhancer starr_02813 Neighboring gene STARR-seq mESC enhancer starr_02814 Neighboring gene STARR-seq mESC enhancer starr_02815 Neighboring gene ankyrin repeat domain 45 Neighboring gene testis expressed 50

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Structural insights into human CCAN complex assembled onto DNA. Tian T, et al. Cell Discov, 2022 Sep 9. PMID 36085283, Free PMC Article
  2. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
  3. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
  4. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
  5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (2) 

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in chromosome segregation NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
part_of inner kinetochore ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
centromere protein L

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159930.2 → NP_001153402.1  centromere protein L

    See identical proteins and their annotated locations for NP_001153402.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the protein.
    Source sequence(s)
    BC060191, BC063765, BC116944, DV649208
    Consensus CDS
    CCDS48413.1
    UniProtKB/Swiss-Prot
    E9QKF0, Q3U3S3, Q9CSU9
    UniProtKB/TrEMBL
    Q14A61
    Related
    ENSMUSP00000107247.4, ENSMUST00000111620.10
    Conserved Domains (1) summary
    pfam13092
    Location:178 → 324
    CENP-L; Kinetochore complex Sim4 subunit Fta1

RNA

  1. NR_131028.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC138640, AK150539, BC063765, DV649208

  2. NR_131029.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in an internal exon and contains an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK053363, BC063765, DV649208

  3. NR_131030.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC063765, DV649208
    Related
    ENSMUST00000143486.7

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    160898337..160914294
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_027429.3: Suppressed sequence

    Description
    NM_027429.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3U3S3.2 GenPept UniProtKB/Swiss-Prot:Q3U3S3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools