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Unc13d unc-13 homolog D [ Mus musculus (house mouse) ]

Gene ID: 70450, updated on 14-Aug-2019

Summary

Official Symbol
Unc13dprovided by MGI
Official Full Name
unc-13 homolog Dprovided by MGI
Primary source
MGI:MGI:1917700
See related
Ensembl:ENSMUSG00000057948
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Jinx; Munc13-4; mFLJ00067; 2610108D09Rik
Expression
Broad expression in thymus adult (RPKM 20.5), spleen adult (RPKM 18.5) and 15 other tissues See more
Orthologs

Genomic context

See Unc13d in Genome Data Viewer
Location:
11; 11 E2
Exon count:
35
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (116062095..116078495, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (115923410..115939275, complement)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene H3.3 histone B Neighboring gene unkempt family zinc finger Neighboring gene predicted gene, 38482 Neighboring gene WW domain binding protein 2 Neighboring gene tripartite motif-containing 47

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Chemically induced (ENU) (1)  1 citation

Pathways from BioSystems

General gene information

Homology

Clone Names

  • FLJ00067

Gene Ontology Provided by MGI

Function Evidence Code Pubs
Rab GTPase binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
defense response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
dense core granule priming ISO
Inferred from Sequence Orthology
more info
 
exocytosis IEA
Inferred from Electronic Annotation
more info
 
germinal center formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
granuloma formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
natural killer cell degranulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
phagocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of exocytosis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of regulated secretory pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of substrate adhesion-dependent cell spreading IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of mast cell degranulation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
Weibel-Palade body ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
endosome IEA
Inferred from Electronic Annotation
more info
 
exocytic vesicle ISO
Inferred from Sequence Orthology
more info
 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
lysosome ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein unc-13 homolog D
Names
likely ortholog of H. sapiens unc-13 homolog D (UNC13D)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009573.2NP_001009573.2  protein unc-13 homolog D

    See identical proteins and their annotated locations for NP_001009573.2

    Status: VALIDATED

    Source sequence(s)
    AK220199, BC046519, BG146628, CF164660
    Consensus CDS
    CCDS25656.1
    UniProtKB/Swiss-Prot
    B2RUP2
    UniProtKB/TrEMBL
    Q80UG7
    Related
    ENSMUSP00000074549.2, ENSMUST00000075036.8
    Conserved Domains (3) summary
    cd04009
    Location:9071042
    C2B_Munc13-like; C2 domain second repeat in Munc13 (mammalian uncoordinated)-like proteins
    cd08676
    Location:83262
    C2A_Munc13-like; C2 domain first repeat in Munc13 (mammalian uncoordinated)-like proteins
    pfam10540
    Location:787888
    Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p6 C57BL/6J

    Range
    116062095..116078495 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534189.3XP_006534252.1  protein unc-13 homolog D isoform X1

    See identical proteins and their annotated locations for XP_006534252.1

    UniProtKB/Swiss-Prot
    B2RUP2
    Related
    ENSMUSP00000102059.1, ENSMUST00000106451.7
    Conserved Domains (3) summary
    cd04009
    Location:9091044
    C2B_Munc13-like; C2 domain second repeat in Munc13 (mammalian uncoordinated)-like proteins
    cd08676
    Location:83262
    C2A_Munc13-like; C2 domain first repeat in Munc13 (mammalian uncoordinated)-like proteins
    pfam10540
    Location:789890
    Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain
  2. XM_006534188.3XP_006534251.1  protein unc-13 homolog D isoform X1

    See identical proteins and their annotated locations for XP_006534251.1

    UniProtKB/Swiss-Prot
    B2RUP2
    Conserved Domains (3) summary
    cd04009
    Location:9091044
    C2B_Munc13-like; C2 domain second repeat in Munc13 (mammalian uncoordinated)-like proteins
    cd08676
    Location:83262
    C2A_Munc13-like; C2 domain first repeat in Munc13 (mammalian uncoordinated)-like proteins
    pfam10540
    Location:789890
    Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain
  3. XM_006534190.3XP_006534253.1  protein unc-13 homolog D isoform X1

    See identical proteins and their annotated locations for XP_006534253.1

    UniProtKB/Swiss-Prot
    B2RUP2
    Related
    ENSMUSP00000102058.1, ENSMUST00000106450.7
    Conserved Domains (3) summary
    cd04009
    Location:9091044
    C2B_Munc13-like; C2 domain second repeat in Munc13 (mammalian uncoordinated)-like proteins
    cd08676
    Location:83262
    C2A_Munc13-like; C2 domain first repeat in Munc13 (mammalian uncoordinated)-like proteins
    pfam10540
    Location:789890
    Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain
  4. XM_006534192.4XP_006534255.1  protein unc-13 homolog D isoform X2

    Conserved Domains (3) summary
    cd04009
    Location:8981033
    C2B_Munc13-like; C2 domain second repeat in Munc13 (mammalian uncoordinated)-like proteins
    cd08676
    Location:72251
    C2A_Munc13-like; C2 domain first repeat in Munc13 (mammalian uncoordinated)-like proteins
    pfam10540
    Location:778879
    Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain

RNA

  1. XR_879738.3 RNA Sequence

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