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Polr3f polymerase (RNA) III (DNA directed) polypeptide F [ Mus musculus (house mouse) ]

Gene ID: 70408, updated on 8-Dec-2022

Summary

Official Symbol
Polr3fprovided by MGI
Official Full Name
polymerase (RNA) III (DNA directed) polypeptide Fprovided by MGI
Primary source
MGI:MGI:1924086
See related
Ensembl:ENSMUSG00000027427 AllianceGenome:MGI:1924086
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RPC6; RPC39; 2810411G20Rik; 3010019O03Rik; 3110032A07Rik
Summary
Predicted to enable double-stranded DNA binding activity. Predicted to be involved in positive regulation of innate immune response and positive regulation of interferon-beta production. Predicted to act upstream of or within defense response to virus and innate immune response. Predicted to be located in nucleus. Predicted to be part of RNA polymerase III complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and respiratory system. Orthologous to human POLR3F (RNA polymerase III subunit F). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 5.5), CNS E14 (RPKM 4.5) and 25 other tissues See more
Orthologs
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Genomic context

See Polr3f in Genome Data Viewer
Location:
2; 2 G1
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (144369665..144383699)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (144527745..144541779)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene zinc finger protein 133, pseudogene Neighboring gene zinc finger protein 133, pseudogene Neighboring gene double zinc ribbon and ankyrin repeat domains 1 Neighboring gene retinoblastoma binding protein 9, serine hydrolase Neighboring gene predicted gene, 34292 Neighboring gene SEC23 homolog B, COPII coat complex component

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC11656

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to RNA polymerase III activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within defense response to virus IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of innate immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interferon-beta production ISO
Inferred from Sequence Orthology
more info
 
involved_in transcription by RNA polymerase III IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of DNA-directed RNA polymerase complex IEA
Inferred from Electronic Annotation
more info
 
part_of RNA polymerase III complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of RNA polymerase III complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
DNA-directed RNA polymerase III subunit RPC6
Names
DNA-directed RNA polymerase III subunit F
RNA polymerase III subunit C6
NP_084039.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029763.3NP_084039.2  DNA-directed RNA polymerase III subunit RPC6

    See identical proteins and their annotated locations for NP_084039.2

    Status: VALIDATED

    Source sequence(s)
    AK029286, AK036166
    Consensus CDS
    CCDS16820.1
    UniProtKB/Swiss-Prot
    Q544K6, Q921X6
    UniProtKB/TrEMBL
    A0A6P5P644, A0A8C6HPQ7, A8QKB1, Q8C108
    Related
    ENSMUSP00000028914.3, ENSMUST00000028914.9
    Conserved Domains (1) summary
    pfam05158
    Location:12315
    RNA_pol_Rpc34; RNA polymerase Rpc34 subunit

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    144369665..144383699
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_027417.1: Suppressed sequence

    Description
    NM_027417.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.