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TGFB1 transforming growth factor beta 1 [ Homo sapiens (human) ]

Gene ID: 7040, updated on 23-Jul-2024

Summary

Official Symbol
TGFB1provided by HGNC
Official Full Name
transforming growth factor beta 1provided by HGNC
Primary source
HGNC:HGNC:11766
See related
Ensembl:ENSG00000105329 MIM:190180; AllianceGenome:HGNC:11766
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CED; LAP; DPD1; TGFB; IBDIMDE; TGFbeta; TGF-beta1
Summary
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGFB family members. This encoded protein regulates cell proliferation, differentiation and growth, and can modulate expression and activation of other growth factors including interferon gamma and tumor necrosis factor alpha. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease. [provided by RefSeq, Aug 2016]
Expression
Broad expression in spleen (RPKM 38.0), bone marrow (RPKM 32.1) and 23 other tissues See more
Orthologs
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Genomic context

See TGFB1 in Genome Data Viewer
Location:
19q13.2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (41330323..41353922, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (44151181..44174790, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (41836228..41859827, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein U like 1 Neighboring gene uncharacterized LOC105372401 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14673 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14674 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:41825837-41826574 Neighboring gene coiled-coil domain containing 97 Neighboring gene Sharpr-MPRA regulatory regions 2264 and 10656 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:41828472-41828958 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:41829057-41829826 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:41830597-41831366 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:41831367-41832136 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14675 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10658 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:41833547-41834068 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14676 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14677 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10660 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10661 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10662 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10663 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10664 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:41860203-41860704 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14679 Neighboring gene B9 domain containing 2 Neighboring gene transmembrane protein 91 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10665 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:41885758-41885931 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:41889835-41890334 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:41892254-41892432 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:41903234-41903906 Neighboring gene exosome component 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide meta-analysis identifies new susceptibility loci for migraine.
EBI GWAS Catalog
Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
EBI GWAS Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 replication is restricted by TGFB1 and SMAD2 in Langerhans cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Recombinant HIV-1 Env (gp120) induces high levels of TGFB1 mRNA expression in CD34+ hematopoietic progenitor cells PubMed
env HIV-1 gp120-induced downregulation of CD80 and upregulation of FCRL4 involve the TGF-beta1 signaling pathway in human B cells PubMed
env Inactivated HIV or gp120 increases HCV replication and enhances HCV-regulated transforming growth factor (TGF)-beta1 expression PubMed
env HIV-1 gp120-induced apoptosis in human proximal renal tubular cells is significantly enhanced by p300, and Smad7 and an anti-TGF-beta antibody inhibit this effect of p300 PubMed
env HIV-1 gp120 and p300 synergistically increase TGF-beta, ATF-2 and activating protein-1 (AP-1) expression leading to tubular cell apoptosis; in addition, HIV-1 gp120 treatment causes phosphorylation of Smad2 and downregulation of c-Jun PubMed
env HIV-1 gp120-mediated suppression of CD34+ cell growth is entirely due to an upregulation of endogenous TGF-beta 1 PubMed
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 induces TGF-beta production in human PBMC PubMed
env HIV-1 gp160 and serum-free macrophage supernatant (MSP) enhance synthesis of type IV collagen by mesangial cells; anti-TGF-beta antibodies attenuate this gp160/MSP-induced collagen synthesis PubMed
Tat tat Primary human Muller glia cells treated with both HIV-1 clade B and clade C Tat upregulate the expression of anti-inflammatory proteins IL-10 and TGF-beta PubMed
tat HIV-1 Tat protein permits the survival and replication of a non-pathogenic trypanosomatid in macrophages through TGF-beta1 production PubMed
tat HIV-1 Tat binds to GLI2 and GLI2 binds to the human TGFB1 promoter, suggesting a potential mechanism for TGFB1 induction in HIV-1 infection PubMed
tat HIV-1 Tat and TGF-beta secretion enhance parasite entry in human macrophages by upregulating surface expression of CD91/LRP-1 PubMed
tat TGF-beta inhibits/down-modulates HIV-1 Tat-induced IL-8 production PubMed
tat HIV-1 Tat upregulation of TGF-beta 1 is likely involved in the regulation of MCP-1 transcription by Tat and the interactions of Tat with Smad-3 and Smad-4, two transcription factors whose activities are induced by the TGF-beta 1 pathway PubMed
tat HIV-1 Tat upregulates TGF-beta 1 expression in a manner involving IL-6, an effect mediated by Tat amino acids 1-48 and potentially associated with immunosuppression, nephropathy, hematopoietic suppression and glomerulosclerosis PubMed
Vpr vpr HIV-1 Vpr impairs NK cell function through cytokine dysregulation, including diminshed expression of CD107a, reduced production of IFN-gamma, differential regulation of IL-12 and TGF-beta, and activation of the Smad3 signalling pathway PubMed
Vpu vpu Antibodies against TGF-beta or a TGF-beta receptor inhibitor SB431452 reverse Vpu-mediated profibrogenic activation of LX2 cells, suggesting that TGF-beta mediates these effects PubMed
vpu HIV-1 Vpu-expressing U937 monocytes coculture with LX2 stellate cells to activate release of transforming growth factor beta to culture supernatant, which correlates with increased activity of the AP-1 transcription factor PubMed
capsid gag Treatment of monocyte-derived dendritic cells with TGF-beta1 significantly enhances their ability to capture HIV-1 particles measured by p24 levels in cells PubMed
gag Transforming growth factor-beta1 is involved in the enhanced expression of HIV-1 by nicotine, as measured by p24 antigen levels in culture supernatants PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables antigen binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cytokine activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cytokine activity TAS
Traceable Author Statement
more info
PubMed 
enables deubiquitinase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables growth factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine/threonine kinase activator activity IEA
Inferred from Electronic Annotation
more info
 
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
enables type I transforming growth factor beta receptor binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables type I transforming growth factor beta receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables type II transforming growth factor beta receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables type II transforming growth factor beta receptor binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables type II transforming growth factor beta receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables type III transforming growth factor beta receptor binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables type III transforming growth factor beta receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in ATP biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in Langerhans cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in T cell homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains IEA
Inferred from Electronic Annotation
more info
 
involved_in aortic valve morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in branch elongation involved in mammary gland duct branching IEA
Inferred from Electronic Annotation
more info
 
involved_in bronchiole development IEA
Inferred from Electronic Annotation
more info
 
involved_in canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in cell morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in cell-cell junction organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to dexamethasone stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to glucose stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to hypoxia IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to insulin-like growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to ionizing radiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to low-density lipoprotein particle stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to mechanical stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to transforming growth factor beta stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to transforming growth factor beta stimulus IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cellular response to virus IEA
Inferred from Electronic Annotation
more info
 
involved_in chondrocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in columnar/cuboidal epithelial cell maturation IEA
Inferred from Electronic Annotation
more info
 
involved_in connective tissue replacement involved in inflammatory response wound healing TAS
Traceable Author Statement
more info
PubMed 
involved_in defense response to fungus IEA
Inferred from Electronic Annotation
more info
 
involved_in digestive tract development IEA
Inferred from Electronic Annotation
more info
 
involved_in embryonic liver development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in endoderm development IEA
Inferred from Electronic Annotation
more info
 
involved_in epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of epithelial to mesenchymal transition IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within epithelial to mesenchymal transition IDA
Inferred from Direct Assay
more info
PubMed 
involved_in epithelial to mesenchymal transition IDA
Inferred from Direct Assay
more info
PubMed 
involved_in extracellular matrix assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in extrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in face morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in female pregnancy IEA
Inferred from Electronic Annotation
more info
 
involved_in frontal suture morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in germ cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in heart development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in heart valve morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in hematopoietic progenitor cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in hyaluronan catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in inner ear development IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular calcium ion homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in lens fiber cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in liver regeneration IEA
Inferred from Electronic Annotation
more info
 
involved_in lung alveolus development IEA
Inferred from Electronic Annotation
more info
 
involved_in lymph node development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in macrophage derived foam cell differentiation IC
Inferred by Curator
more info
PubMed 
involved_in mammary gland branching involved in thelarche IEA
Inferred from Electronic Annotation
more info
 
involved_in membrane protein intracellular domain proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in muscle cell cellular homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in myelination IEA
Inferred from Electronic Annotation
more info
 
involved_in myofibroblast differentiation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of biomineral tissue development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of blood vessel endothelial cell migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in negative regulation of cell growth IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell-cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of epithelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of extracellular matrix disassembly TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of negative regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of hyaluronan biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of interleukin-17 production IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of macrophage cytokine production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of miRNA transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of myoblast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of neuroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of ossification IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of phagocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of protein localization to plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of release of sequestered calcium ion into cytosol IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of skeletal muscle tissue development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in neural tube closure ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in neural tube development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in odontoblast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in odontogenesis of dentin-containing tooth IEA
Inferred from Electronic Annotation
more info
 
involved_in oligodendrocyte development IEA
Inferred from Electronic Annotation
more info
 
involved_in osteoclast differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in phosphate-containing compound metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phospholipid homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of SMAD protein signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of SMAD protein signal transduction IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of SMAD protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of blood vessel endothelial cell migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of branching involved in ureteric bud morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of canonical NF-kappaB signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of positive regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cardiac muscle cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of chemokine (C-X-C motif) ligand 2 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of collagen biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of collagen biosynthetic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of collagen biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of endothelial cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of positive regulation of epidermal growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of epithelial to mesenchymal transition IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of epithelial to mesenchymal transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of epithelial to mesenchymal transition NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of exit from mitosis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of positive regulation of extracellular matrix assembly ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in positive regulation of extracellular matrix assembly NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of extracellular matrix assembly TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of fibroblast migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-17 production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of positive regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of isotype switching to IgA isotypes IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of mesenchymal stem cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of miRNA transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of microglia differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of mononuclear cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of odontogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of primary miRNA processing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein import into nucleus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein localization to nucleus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein secretion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein-containing complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of receptor signaling pathway via STAT IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of regulatory T cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of smooth muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of smooth muscle cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of superoxide anion generation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of vascular endothelial growth factor production TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of vascular permeability IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of vasculature development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein export from nucleus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in receptor catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of blood vessel remodeling NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of blood vessel remodeling TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of branching involved in mammary gland duct morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cartilage development IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell migration TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of enamel mineralization IEA
Inferred from Electronic Annotation
more info
 
NOT involved_in regulation of epithelial to mesenchymal transition involved in endocardial cushion formation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of interleukin-23 production IEA
Inferred from Electronic Annotation
more info
 
NOT involved_in regulation of miRNA transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of protein import into nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of sodium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of striated muscle tissue development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulatory T cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to cholesterol IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to estradiol IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to immobilization stress IEA
Inferred from Electronic Annotation
more info
 
involved_in response to laminar fluid shear stress IEA
Inferred from Electronic Annotation
more info
 
involved_in response to progesterone IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to salt IEA
Inferred from Electronic Annotation
more info
 
involved_in response to vitamin D IEA
Inferred from Electronic Annotation
more info
 
involved_in response to wounding IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in retina vasculature development in camera-type eye IEA
Inferred from Electronic Annotation
more info
 
involved_in salivary gland morphogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in stem cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in surfactant homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in tolerance induction to self antigen IEA
Inferred from Electronic Annotation
more info
 
involved_in transforming growth factor beta receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in transforming growth factor beta receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in transforming growth factor beta receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transforming growth factor beta receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in ureteric bud development IEA
Inferred from Electronic Annotation
more info
 
involved_in vasculogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in ventricular cardiac muscle tissue morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in Golgi lumen TAS
Traceable Author Statement
more info
 
located_in axon IEA
Inferred from Electronic Annotation
more info
 
located_in blood microparticle HDA PubMed 
located_in cell surface IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in collagen-containing extracellular matrix HDA PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular matrix ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in extracellular space IC
Inferred by Curator
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with microvillus IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in platelet alpha granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
transforming growth factor beta-1 proprotein
Names
TGF-beta-1
latency-associated peptide
prepro-transforming growth factor beta-1
transforming growth factor beta1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013364.1 RefSeqGene

    Range
    5005..28604
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000660.7NP_000651.3  transforming growth factor beta-1 proprotein preproprotein

    See identical proteins and their annotated locations for NP_000651.3

    Status: REVIEWED

    Source sequence(s)
    AC011462, BC000125, BM692012, X02812
    Consensus CDS
    CCDS33031.1
    UniProtKB/Swiss-Prot
    A8K792, P01137, Q9UCG4
    UniProtKB/TrEMBL
    A0A499FJK2
    Related
    ENSP00000221930.4, ENST00000221930.6
    Conserved Domains (2) summary
    cd19384
    Location:292390
    TGF_beta_TGFB1; transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-1 (TGF-beta-1) and similar proteins
    pfam00688
    Location:30261
    TGFb_propeptide; TGF-beta propeptide

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    41330323..41353922 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527242.3XP_011525544.1  transforming growth factor beta-1 proprotein isoform X1

    See identical proteins and their annotated locations for XP_011525544.1

    Conserved Domains (2) summary
    cd19384
    Location:293391
    TGF_beta_TGFB1; transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-1 (TGF-beta-1) and similar proteins
    pfam00688
    Location:30262
    TGFb_propeptide; TGF-beta propeptide

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    44151181..44174790 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321897.1XP_054177872.1  transforming growth factor beta-1 proprotein isoform X1