TGFB1 transforming growth factor beta 1 [ Homo sapiens (human) ]

Gene ID: 7040, updated on 25-Jan-2021

Summary

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Official Symbol: TGFB1provided by HGNC
Official Full Name: transforming growth factor beta 1provided by HGNC
Primary source: HGNC:HGNC:11766
See related: Ensembl:ENSG00000105329 MIM:190180
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CED; LAP; DPD1; TGFB; IBDIMDE; TGFbeta; TGF-beta1
Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGFB family members. This encoded protein regulates cell proliferation, differentiation and growth, and can modulate expression and activation of other growth factors including interferon gamma and tumor necrosis factor alpha. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease. [provided by RefSeq, Aug 2016]
Expression: Broad expression in spleen (RPKM 38.0), bone marrow (RPKM 32.1) and 23 other tissues See more
Orthologs: mouse all
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Genomic context

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See TGFB1 in Genome Data Viewer

Location:: 19q13.2

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
109.20201120	current	GRCh38.p13 (GCF_000001405.39)	19	NC_000019.10 (41330323..41353922, complement)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (41836812..41859831, complement)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Association of single nucleotide polymorphism of transforming growth factor beta1 (T29C) in breast cancer patients: a case control study in Rawalpindi.
Title: Association of single nucleotide polymorphism of transforming growth factor β1 (T29C) in breast cancer patients: a case control study in Rawalpindi.
TGFbeta-mediated expression of TGFbeta-activating integrins in SSc monocytes: disturbed activation of latent TGFbeta?
Title: TGFβ-mediated expression of TGFβ-activating integrins in SSc monocytes: disturbed activation of latent TGFβ?
Mediator complex subunit 16 is down-regulated in papillary thyroid cancer, leading to increased transforming growth factor-beta signaling and radioiodine resistance.
Title: Mediator complex subunit 16 is down-regulated in papillary thyroid cancer, leading to increased transforming growth factor-β signaling and radioiodine resistance.
Obesity reduces mammary epithelial cell TGFbeta1 activity through macrophage-mediated extracellular matrix remodeling.
Title: Obesity reduces mammary epithelial cell TGFβ1 activity through macrophage-mediated extracellular matrix remodeling.
Bone marrow stromal cells induce an ALDH+ stem cell-like phenotype and enhance therapy resistance in AML through a TGF-beta-p38-ALDH2 pathway.
Title: Bone marrow stromal cells induce an ALDH+ stem cell-like phenotype and enhance therapy resistance in AML through a TGF-β-p38-ALDH2 pathway.
PM014 attenuates radiation-induced pulmonary fibrosis via regulating NF-kB and TGF-b1/NOX4 pathways.
Title: PM014 attenuates radiation-induced pulmonary fibrosis via regulating NF-kB and TGF-b1/NOX4 pathways.
TGFbeta1 single-nucleotide polymorphism C-509T alters mucosal cell function in pediatric eosinophilic esophagitis.
Title: TGFβ1 single-nucleotide polymorphism C-509T alters mucosal cell function in pediatric eosinophilic esophagitis.
Isoliquiritigenin inhibits TGF-beta1-induced fibrogenesis through activating autophagy via PI3K/AKT/mTOR pathway in MRC-5 cells.
Title: Isoliquiritigenin inhibits TGF-β1-induced fibrogenesis through activating autophagy via PI3K/AKT/mTOR pathway in MRC-5 cells.
miR-4458 inhibits the epithelial-mesenchymal transition of hepatocellular carcinoma cells by suppressing the TGF-beta signaling pathway via targeting TGFBR1.
Title: miR-4458 inhibits the epithelial-mesenchymal transition of hepatocellular carcinoma cells by suppressing the TGF-β signaling pathway via targeting TGFBR1.
KLF2 inhibits TGF-beta-mediated cancer cell motility in hepatocellular carcinoma.
Title: KLF2 inhibits TGF-β-mediated cancer cell motility in hepatocellular carcinoma.

Submit: New GeneRIF Correction See all GeneRIFs (3795)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Cystic fibrosis MedGen: C0010674 OMIM: 219700 GeneReviews: Cystic Fibrosis and Congenital Absence of the Vas Deferens	Compare labs
Diaphyseal dysplasia MedGen: C4551852 OMIM: 131300 GeneReviews: Camurati-Engelmann Disease	Compare labs
Genome-wide meta-analysis identifies new susceptibility loci for migraine. GeneReviews: Not available
Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk. GeneReviews: Not available
not provided MedGen: C4748708 OMIM: 618213 GeneReviews: Not available	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
HIV-1 replication is restricted by TGFB1 and SMAD2 in Langerhans cells	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Recombinant HIV-1 Env (gp120) induces high levels of TGFB1 mRNA expression in CD34+ hematopoietic progenitor cells	PubMed
	env	HIV-1 gp120-induced downregulation of CD80 and upregulation of FCRL4 involve the TGF-beta1 signaling pathway in human B cells	PubMed
	env	Inactivated HIV or gp120 increases HCV replication and enhances HCV-regulated transforming growth factor (TGF)-beta1 expression	PubMed
	env	HIV-1 gp120-induced apoptosis in human proximal renal tubular cells is significantly enhanced by p300, and Smad7 and an anti-TGF-beta antibody inhibit this effect of p300	PubMed
	env	HIV-1 gp120 and p300 synergistically increase TGF-beta, ATF-2 and activating protein-1 (AP-1) expression leading to tubular cell apoptosis; in addition, HIV-1 gp120 treatment causes phosphorylation of Smad2 and downregulation of c-Jun	PubMed
	env	HIV-1 gp120-mediated suppression of CD34+ cell growth is entirely due to an upregulation of endogenous TGF-beta 1	PubMed
Envelope surface glycoprotein gp160, precursor	env	HIV-1 gp160 induces TGF-beta production in human PBMC	PubMed
	env	HIV-1 gp160 and serum-free macrophage supernatant (MSP) enhance synthesis of type IV collagen by mesangial cells; anti-TGF-beta antibodies attenuate this gp160/MSP-induced collagen synthesis	PubMed
Tat	tat	Primary human Muller glia cells treated with both HIV-1 clade B and clade C Tat upregulate the expression of anti-inflammatory proteins IL-10 and TGF-beta	PubMed
	tat	HIV-1 Tat protein permits the survival and replication of a non-pathogenic trypanosomatid in macrophages through TGF-beta1 production	PubMed
	tat	HIV-1 Tat binds to GLI2 and GLI2 binds to the human TGFB1 promoter, suggesting a potential mechanism for TGFB1 induction in HIV-1 infection	PubMed
	tat	HIV-1 Tat and TGF-beta secretion enhance parasite entry in human macrophages by upregulating surface expression of CD91/LRP-1	PubMed
	tat	TGF-beta inhibits/down-modulates HIV-1 Tat-induced IL-8 production	PubMed
	tat	HIV-1 Tat upregulation of TGF-beta 1 is likely involved in the regulation of MCP-1 transcription by Tat and the interactions of Tat with Smad-3 and Smad-4, two transcription factors whose activities are induced by the TGF-beta 1 pathway	PubMed
	tat	HIV-1 Tat upregulates TGF-beta 1 expression in a manner involving IL-6, an effect mediated by Tat amino acids 1-48 and potentially associated with immunosuppression, nephropathy, hematopoietic suppression and glomerulosclerosis	PubMed
Vpr	vpr	HIV-1 Vpr impairs NK cell function through cytokine dysregulation, including diminshed expression of CD107a, reduced production of IFN-gamma, differential regulation of IL-12 and TGF-beta, and activation of the Smad3 signalling pathway	PubMed
Vpu	vpu	Antibodies against TGF-beta or a TGF-beta receptor inhibitor SB431452 reverse Vpu-mediated profibrogenic activation of LX2 cells, suggesting that TGF-beta mediates these effects	PubMed
	vpu	HIV-1 Vpu-expressing U937 monocytes coculture with LX2 stellate cells to activate release of transforming growth factor beta to culture supernatant, which correlates with increased activity of the AP-1 transcription factor	PubMed
capsid	gag	Treatment of monocyte-derived dendritic cells with TGF-beta1 significantly enhances their ability to capture HIV-1 particles measured by p24 levels in cells	PubMed
	gag	Transforming growth factor-beta1 is involved in the enhanced expression of HIV-1 by nicotine, as measured by p24 antigen levels in culture supernatants	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

GDB:624780 (e-PCR)
- UniSTS:158357

GDB:624783 (e-PCR)
- UniSTS:158358

TGFB1 (e-PCR), detects polymorphism
- UniSTS:498077

STS-X02812 (e-PCR)
- UniSTS:19102

RH76684 (e-PCR)
- UniSTS:90301

Homology

Homologs of the TGFB1 gene: The TGFB1 gene is conserved in chimpanzee, dog, cow, mouse, rat, zebrafish, and frog.
Orthologs from Annotation Pipeline: 183 organisms have orthologs with human gene TGFB1
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
antigen binding	IPI Inferred from Physical Interaction more info	PubMed
cytokine activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
cytokine activity	TAS Traceable Author Statement more info	PubMed
enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
growth factor activity	IEA Inferred from Electronic Annotation more info
identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
type I transforming growth factor beta receptor binding	IMP Inferred from Mutant Phenotype more info	PubMed
type I transforming growth factor beta receptor binding	IPI Inferred from Physical Interaction more info	PubMed
type II transforming growth factor beta receptor binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
type II transforming growth factor beta receptor binding	IDA Inferred from Direct Assay more info	PubMed
type II transforming growth factor beta receptor binding	IMP Inferred from Mutant Phenotype more info	PubMed
type II transforming growth factor beta receptor binding	IPI Inferred from Physical Interaction more info	PubMed
type III transforming growth factor beta receptor binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
type III transforming growth factor beta receptor binding	IMP Inferred from Mutant Phenotype more info	PubMed
type III transforming growth factor beta receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
ATP biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
SMAD protein complex assembly	IDA Inferred from Direct Assay more info	PubMed
SMAD protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info	PubMed
aortic valve morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
cell cycle arrest	IDA Inferred from Direct Assay more info	PubMed
cell migration	IDA Inferred from Direct Assay more info	PubMed
cell-cell junction organization	IDA Inferred from Direct Assay more info	PubMed
cellular response to organic cyclic compound	IDA Inferred from Direct Assay more info	PubMed
cellular response to transforming growth factor beta stimulus	IDA Inferred from Direct Assay more info	PubMed
cellular response to transforming growth factor beta stimulus	IGI Inferred from Genetic Interaction more info	PubMed
chondrocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
common-partner SMAD protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
connective tissue replacement involved in inflammatory response wound healing	TAS Traceable Author Statement more info	PubMed
cytokine-mediated signaling pathway	TAS Traceable Author Statement more info
embryonic liver development	ISS Inferred from Sequence or Structural Similarity more info
epidermal growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
epithelial to mesenchymal transition	IDA Inferred from Direct Assay more info	PubMed
extracellular matrix assembly	IDA Inferred from Direct Assay more info	PubMed
extrinsic apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed
heart development	ISS Inferred from Sequence or Structural Similarity more info
heart valve morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
hematopoietic progenitor cell differentiation	IDA Inferred from Direct Assay more info	PubMed
hyaluronan catabolic process	IDA Inferred from Direct Assay more info	PubMed
inflammatory response	IDA Inferred from Direct Assay more info	PubMed
leukocyte migration	TAS Traceable Author Statement more info
lipopolysaccharide-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
lymph node development	ISS Inferred from Sequence or Structural Similarity more info
macrophage derived foam cell differentiation	IC Inferred by Curator more info	PubMed
membrane protein intracellular domain proteolysis	IDA Inferred from Direct Assay more info	PubMed
negative regulation of biomineral tissue development	IDA Inferred from Direct Assay more info	PubMed
negative regulation of blood vessel endothelial cell migration	IDA Inferred from Direct Assay more info	PubMed
negative regulation of cell cycle	IDA Inferred from Direct Assay more info	PubMed
negative regulation of cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
negative regulation of cell growth	IDA Inferred from Direct Assay more info	PubMed
negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of cell-cell adhesion	IDA Inferred from Direct Assay more info	PubMed
negative regulation of cytolysis	IDA Inferred from Direct Assay more info	PubMed
negative regulation of epithelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
negative regulation of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of extracellular matrix disassembly	IC Inferred by Curator more info	PubMed
negative regulation of fat cell differentiation	IDA Inferred from Direct Assay more info	PubMed
negative regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
negative regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
negative regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of gene silencing by miRNA	IGI Inferred from Genetic Interaction more info	PubMed
negative regulation of hyaluronan biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
negative regulation of macrophage cytokine production	IDA Inferred from Direct Assay more info	PubMed
negative regulation of mitotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
negative regulation of myoblast differentiation	IDA Inferred from Direct Assay more info	PubMed
negative regulation of production of miRNAs involved in gene silencing by miRNA	IGI Inferred from Genetic Interaction more info	PubMed
negative regulation of protein localization to plasma membrane	IDA Inferred from Direct Assay more info	PubMed
negative regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
negative regulation of skeletal muscle tissue development	IDA Inferred from Direct Assay more info	PubMed
negative regulation of transcription, DNA-templated	IDA Inferred from Direct Assay more info	PubMed
negative regulation of transforming growth factor beta receptor signaling pathway	TAS Traceable Author Statement more info
neural tube closure	ISS Inferred from Sequence or Structural Similarity more info
neural tube development	ISS Inferred from Sequence or Structural Similarity more info
ossification involved in bone remodeling	IEP Inferred from Expression Pattern more info	PubMed
pathway-restricted SMAD protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
phosphate-containing compound metabolic process	IDA Inferred from Direct Assay more info	PubMed
platelet degranulation	TAS Traceable Author Statement more info
positive regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
positive regulation of MAP kinase activity	IDA Inferred from Direct Assay more info	PubMed
positive regulation of NAD+ ADP-ribosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
positive regulation of SMAD protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
positive regulation of blood vessel endothelial cell migration	IDA Inferred from Direct Assay more info	PubMed
positive regulation of bone mineralization	IEP Inferred from Expression Pattern more info	PubMed
positive regulation of canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
positive regulation of cardiac muscle cell differentiation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of cell division	IEA Inferred from Electronic Annotation more info
positive regulation of cell migration	IDA Inferred from Direct Assay more info	PubMed
positive regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of cellular protein metabolic process	IDA Inferred from Direct Assay more info	PubMed
positive regulation of chemotaxis	IDA Inferred from Direct Assay more info	PubMed
positive regulation of collagen biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
positive regulation of collagen biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
positive regulation of collagen biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of epithelial to mesenchymal transition	IDA Inferred from Direct Assay more info	PubMed
positive regulation of epithelial to mesenchymal transition	NAS Non-traceable Author Statement more info	PubMed
positive regulation of extracellular matrix assembly	IC Inferred by Curator more info	PubMed
positive regulation of fibroblast migration	IDA Inferred from Direct Assay more info	PubMed
positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
positive regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of interleukin-17 production	IDA Inferred from Direct Assay more info	PubMed
positive regulation of isotype switching to IgA isotypes	IDA Inferred from Direct Assay more info	PubMed
positive regulation of microglia differentiation	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of pathway-restricted SMAD protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
positive regulation of pathway-restricted SMAD protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of peptidyl-serine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of peptidyl-threonine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of phosphatidylinositol 3-kinase activity	IDA Inferred from Direct Assay more info	PubMed
positive regulation of pri-miRNA transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
positive regulation of production of miRNAs involved in gene silencing by miRNA	IDA Inferred from Direct Assay more info	PubMed
positive regulation of protein dephosphorylation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of protein import into nucleus	IDA Inferred from Direct Assay more info	PubMed
positive regulation of protein kinase B signaling	IDA Inferred from Direct Assay more info	PubMed
positive regulation of protein localization to nucleus	IDA Inferred from Direct Assay more info	PubMed
positive regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of protein secretion	IDA Inferred from Direct Assay more info	PubMed
positive regulation of protein-containing complex assembly	IDA Inferred from Direct Assay more info	PubMed
positive regulation of superoxide anion generation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
positive regulation of transcription regulatory region DNA binding	IDA Inferred from Direct Assay more info	PubMed
positive regulation of transcription, DNA-templated	IDA Inferred from Direct Assay more info	PubMed
positive regulation of transcription, DNA-templated	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of vascular endothelial growth factor production	TAS Traceable Author Statement more info	PubMed
positive regulation of vascular permeability	IDA Inferred from Direct Assay more info	PubMed
protein export from nucleus	IDA Inferred from Direct Assay more info	PubMed
protein kinase B signaling	IMP Inferred from Mutant Phenotype more info	PubMed
protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
receptor catabolic process	IDA Inferred from Direct Assay more info	PubMed
regulation of DNA binding	ISS Inferred from Sequence or Structural Similarity more info
regulation of SMAD protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
regulation of binding	ISS Inferred from Sequence or Structural Similarity more info
regulation of blood vessel remodeling	IC Inferred by Curator more info	PubMed
regulation of blood vessel remodeling	NAS Non-traceable Author Statement more info	PubMed
regulation of cell migration	TAS Traceable Author Statement more info	PubMed
regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
NOT regulation of epithelial to mesenchymal transition involved in endocardial cushion formation	ISS Inferred from Sequence or Structural Similarity more info
NOT regulation of pri-miRNA transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of protein import into nucleus	ISS Inferred from Sequence or Structural Similarity more info
regulation of striated muscle tissue development	ISS Inferred from Sequence or Structural Similarity more info
regulation of transforming growth factor beta receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
response to cholesterol	IDA Inferred from Direct Assay more info	PubMed
response to estradiol	IDA Inferred from Direct Assay more info	PubMed
response to progesterone	IDA Inferred from Direct Assay more info	PubMed
response to wounding	IEP Inferred from Expression Pattern more info	PubMed
salivary gland morphogenesis	IEP Inferred from Expression Pattern more info	PubMed
transforming growth factor beta receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
transforming growth factor beta receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
transforming growth factor beta receptor signaling pathway	TAS Traceable Author Statement more info
transforming growth factor beta receptor signaling pathway involved in heart development	ISS Inferred from Sequence or Structural Similarity more info
vasculogenesis	ISS Inferred from Sequence or Structural Similarity more info
ventricular cardiac muscle tissue morphogenesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
Golgi lumen	TAS Traceable Author Statement more info
blood microparticle	HDA more info	PubMed
cell surface	IMP Inferred from Mutant Phenotype more info	PubMed
collagen-containing extracellular matrix	HDA more info	PubMed
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
extracellular matrix	ISS Inferred from Sequence or Structural Similarity more info
extracellular region	TAS Traceable Author Statement more info
extracellular space	IBA Inferred from Biological aspect of Ancestor more info	PubMed
extracellular space	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with microvillus	IDA Inferred from Direct Assay more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	TAS Traceable Author Statement more info
platelet alpha granule lumen	TAS Traceable Author Statement more info

General protein information

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Preferred Names: transforming growth factor beta-1 proprotein

Names: TGF-beta-1; latency-associated peptide; prepro-transforming growth factor beta-1; transforming growth factor beta1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_013364.1 RefSeqGene

Range

5005..28604

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_000660.7 → NP_000651.3 transforming growth factor beta-1 proprotein preproprotein

See identical proteins and their annotated locations for NP_000651.3

Status: REVIEWED

Source sequence(s)

AC011462, BC000125, BM692012, X02812

Consensus CDS

CCDS33031.1

UniProtKB/Swiss-Prot

P01137

Related

ENSP00000221930.4, ENST00000221930.6

Conserved Domains (2) summary

pfam00688
Location:30 → 261

TGFb_propeptide; TGF-beta propeptide

cd19384
Location:292 → 390

TGF_beta_TGFB1; transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-1 (TGF-beta-1) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

NC_000019.10 Reference GRCh38.p13 Primary Assembly

Range

41330323..41353922 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011527242.2 → XP_011525544.1 transforming growth factor beta-1 proprotein isoform X1

See identical proteins and their annotated locations for XP_011525544.1

Related

ENSP00000504008.1, ENST00000600196.2

Conserved Domains (2) summary

pfam00688
Location:30 → 262

TGFb_propeptide; TGF-beta propeptide

cd19384
Location:293 → 391

TGF_beta_TGFB1; transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-1 (TGF-beta-1) and similar proteins