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TGFB1 transforming growth factor beta 1 [ Homo sapiens (human) ]

Gene ID: 7040, updated on 25-Jan-2021

Summary

Official Symbol
TGFB1provided by HGNC
Official Full Name
transforming growth factor beta 1provided by HGNC
Primary source
HGNC:HGNC:11766
See related
Ensembl:ENSG00000105329 MIM:190180
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CED; LAP; DPD1; TGFB; IBDIMDE; TGFbeta; TGF-beta1
Summary
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGFB family members. This encoded protein regulates cell proliferation, differentiation and growth, and can modulate expression and activation of other growth factors including interferon gamma and tumor necrosis factor alpha. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease. [provided by RefSeq, Aug 2016]
Expression
Broad expression in spleen (RPKM 38.0), bone marrow (RPKM 32.1) and 23 other tissues See more
Orthologs
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Genomic context

See TGFB1 in Genome Data Viewer
Location:
19q13.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (41330323..41353922, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (41836812..41859831, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein U like 1 Neighboring gene RNA, 7SL, cytoplasmic 34, pseudogene Neighboring gene uncharacterized LOC105372401 Neighboring gene coiled-coil domain containing 97 Neighboring gene B9 domain containing 2 Neighboring gene transmembrane protein 91 Neighboring gene exosome component 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Cystic fibrosis Compare labs
Diaphyseal dysplasia
MedGen: C4551852 OMIM: 131300 GeneReviews: Camurati-Engelmann Disease
Compare labs
Genome-wide meta-analysis identifies new susceptibility loci for migraine.
GeneReviews: Not available
Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
GeneReviews: Not available
not provided
MedGen: C4748708 OMIM: 618213 GeneReviews: Not available
Compare labs

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 replication is restricted by TGFB1 and SMAD2 in Langerhans cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Recombinant HIV-1 Env (gp120) induces high levels of TGFB1 mRNA expression in CD34+ hematopoietic progenitor cells PubMed
env HIV-1 gp120-induced downregulation of CD80 and upregulation of FCRL4 involve the TGF-beta1 signaling pathway in human B cells PubMed
env Inactivated HIV or gp120 increases HCV replication and enhances HCV-regulated transforming growth factor (TGF)-beta1 expression PubMed
env HIV-1 gp120-induced apoptosis in human proximal renal tubular cells is significantly enhanced by p300, and Smad7 and an anti-TGF-beta antibody inhibit this effect of p300 PubMed
env HIV-1 gp120 and p300 synergistically increase TGF-beta, ATF-2 and activating protein-1 (AP-1) expression leading to tubular cell apoptosis; in addition, HIV-1 gp120 treatment causes phosphorylation of Smad2 and downregulation of c-Jun PubMed
env HIV-1 gp120-mediated suppression of CD34+ cell growth is entirely due to an upregulation of endogenous TGF-beta 1 PubMed
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 induces TGF-beta production in human PBMC PubMed
env HIV-1 gp160 and serum-free macrophage supernatant (MSP) enhance synthesis of type IV collagen by mesangial cells; anti-TGF-beta antibodies attenuate this gp160/MSP-induced collagen synthesis PubMed
Tat tat Primary human Muller glia cells treated with both HIV-1 clade B and clade C Tat upregulate the expression of anti-inflammatory proteins IL-10 and TGF-beta PubMed
tat HIV-1 Tat protein permits the survival and replication of a non-pathogenic trypanosomatid in macrophages through TGF-beta1 production PubMed
tat HIV-1 Tat binds to GLI2 and GLI2 binds to the human TGFB1 promoter, suggesting a potential mechanism for TGFB1 induction in HIV-1 infection PubMed
tat HIV-1 Tat and TGF-beta secretion enhance parasite entry in human macrophages by upregulating surface expression of CD91/LRP-1 PubMed
tat TGF-beta inhibits/down-modulates HIV-1 Tat-induced IL-8 production PubMed
tat HIV-1 Tat upregulation of TGF-beta 1 is likely involved in the regulation of MCP-1 transcription by Tat and the interactions of Tat with Smad-3 and Smad-4, two transcription factors whose activities are induced by the TGF-beta 1 pathway PubMed
tat HIV-1 Tat upregulates TGF-beta 1 expression in a manner involving IL-6, an effect mediated by Tat amino acids 1-48 and potentially associated with immunosuppression, nephropathy, hematopoietic suppression and glomerulosclerosis PubMed
Vpr vpr HIV-1 Vpr impairs NK cell function through cytokine dysregulation, including diminshed expression of CD107a, reduced production of IFN-gamma, differential regulation of IL-12 and TGF-beta, and activation of the Smad3 signalling pathway PubMed
Vpu vpu Antibodies against TGF-beta or a TGF-beta receptor inhibitor SB431452 reverse Vpu-mediated profibrogenic activation of LX2 cells, suggesting that TGF-beta mediates these effects PubMed
vpu HIV-1 Vpu-expressing U937 monocytes coculture with LX2 stellate cells to activate release of transforming growth factor beta to culture supernatant, which correlates with increased activity of the AP-1 transcription factor PubMed
capsid gag Treatment of monocyte-derived dendritic cells with TGF-beta1 significantly enhances their ability to capture HIV-1 particles measured by p24 levels in cells PubMed
gag Transforming growth factor-beta1 is involved in the enhanced expression of HIV-1 by nicotine, as measured by p24 antigen levels in culture supernatants PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
antigen binding IPI
Inferred from Physical Interaction
more info
PubMed 
cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytokine activity TAS
Traceable Author Statement
more info
PubMed 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
growth factor activity IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
type I transforming growth factor beta receptor binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
type I transforming growth factor beta receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
type II transforming growth factor beta receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
type II transforming growth factor beta receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
type II transforming growth factor beta receptor binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
type II transforming growth factor beta receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
type III transforming growth factor beta receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
type III transforming growth factor beta receptor binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
type III transforming growth factor beta receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
ATP biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
SMAD protein complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
SMAD protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
aortic valve morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell cycle arrest IDA
Inferred from Direct Assay
more info
PubMed 
cell migration IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell junction organization IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to organic cyclic compound IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to transforming growth factor beta stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to transforming growth factor beta stimulus IGI
Inferred from Genetic Interaction
more info
PubMed 
chondrocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
common-partner SMAD protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
connective tissue replacement involved in inflammatory response wound healing TAS
Traceable Author Statement
more info
PubMed 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
embryonic liver development ISS
Inferred from Sequence or Structural Similarity
more info
 
epidermal growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
epithelial to mesenchymal transition IDA
Inferred from Direct Assay
more info
PubMed 
extracellular matrix assembly IDA
Inferred from Direct Assay
more info
PubMed 
extrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
heart development ISS
Inferred from Sequence or Structural Similarity
more info
 
heart valve morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
hematopoietic progenitor cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
hyaluronan catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
leukocyte migration TAS
Traceable Author Statement
more info
 
lipopolysaccharide-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
lymph node development ISS
Inferred from Sequence or Structural Similarity
more info
 
macrophage derived foam cell differentiation IC
Inferred by Curator
more info
PubMed 
membrane protein intracellular domain proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of biomineral tissue development IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of blood vessel endothelial cell migration IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
negative regulation of cell growth IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell-cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cytolysis IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of epithelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of extracellular matrix disassembly IC
Inferred by Curator
more info
PubMed 
negative regulation of fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of gene silencing by miRNA IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of hyaluronan biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of macrophage cytokine production IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of myoblast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of production of miRNAs involved in gene silencing by miRNA IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of protein localization to plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of skeletal muscle tissue development IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transforming growth factor beta receptor signaling pathway TAS
Traceable Author Statement
more info
 
neural tube closure ISS
Inferred from Sequence or Structural Similarity
more info
 
neural tube development ISS
Inferred from Sequence or Structural Similarity
more info
 
ossification involved in bone remodeling IEP
Inferred from Expression Pattern
more info
PubMed 
pathway-restricted SMAD protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
phosphate-containing compound metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
platelet degranulation TAS
Traceable Author Statement
more info
 
positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of MAP kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of NAD+ ADP-ribosyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of SMAD protein signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of blood vessel endothelial cell migration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of bone mineralization IEP
Inferred from Expression Pattern
more info
PubMed 
positive regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cardiac muscle cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell division IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cellular protein metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of collagen biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of collagen biosynthetic process IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of collagen biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of epithelial to mesenchymal transition IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of epithelial to mesenchymal transition NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of extracellular matrix assembly IC
Inferred by Curator
more info
PubMed 
positive regulation of fibroblast migration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of interleukin-17 production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of isotype switching to IgA isotypes IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of microglia differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of pathway-restricted SMAD protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of pathway-restricted SMAD protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of peptidyl-threonine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of phosphatidylinositol 3-kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of pri-miRNA transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of production of miRNAs involved in gene silencing by miRNA IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein import into nucleus IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein kinase B signaling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein localization to nucleus IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein secretion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein-containing complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of superoxide anion generation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription regulatory region DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of vascular endothelial growth factor production TAS
Traceable Author Statement
more info
PubMed 
positive regulation of vascular permeability IDA
Inferred from Direct Assay
more info
PubMed 
protein export from nucleus IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase B signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
receptor catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
regulation of DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of SMAD protein signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
regulation of binding ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of blood vessel remodeling IC
Inferred by Curator
more info
PubMed 
regulation of blood vessel remodeling NAS
Non-traceable Author Statement
more info
PubMed 
regulation of cell migration TAS
Traceable Author Statement
more info
PubMed 
regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT regulation of epithelial to mesenchymal transition involved in endocardial cushion formation ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT regulation of pri-miRNA transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein import into nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of striated muscle tissue development ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
response to cholesterol IDA
Inferred from Direct Assay
more info
PubMed 
response to estradiol IDA
Inferred from Direct Assay
more info
PubMed 
response to progesterone IDA
Inferred from Direct Assay
more info
PubMed 
response to wounding IEP
Inferred from Expression Pattern
more info
PubMed 
salivary gland morphogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
transforming growth factor beta receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
transforming growth factor beta receptor signaling pathway TAS
Traceable Author Statement
more info
 
transforming growth factor beta receptor signaling pathway involved in heart development ISS
Inferred from Sequence or Structural Similarity
more info
 
vasculogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
ventricular cardiac muscle tissue morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
Golgi lumen TAS
Traceable Author Statement
more info
 
blood microparticle HDA PubMed 
cell surface IMP
Inferred from Mutant Phenotype
more info
PubMed 
collagen-containing extracellular matrix HDA PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
extracellular matrix ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with microvillus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
platelet alpha granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
transforming growth factor beta-1 proprotein
Names
TGF-beta-1
latency-associated peptide
prepro-transforming growth factor beta-1
transforming growth factor beta1

NCBI Reference Sequences (RefSeq)

NEW Try the new Data Table view

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013364.1 RefSeqGene

    Range
    5005..28604
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000660.7NP_000651.3  transforming growth factor beta-1 proprotein preproprotein

    See identical proteins and their annotated locations for NP_000651.3

    Status: REVIEWED

    Source sequence(s)
    AC011462, BC000125, BM692012, X02812
    Consensus CDS
    CCDS33031.1
    UniProtKB/Swiss-Prot
    P01137
    Related
    ENSP00000221930.4, ENST00000221930.6
    Conserved Domains (2) summary
    pfam00688
    Location:30261
    TGFb_propeptide; TGF-beta propeptide
    cd19384
    Location:292390
    TGF_beta_TGFB1; transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-1 (TGF-beta-1) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    41330323..41353922 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527242.2XP_011525544.1  transforming growth factor beta-1 proprotein isoform X1

    See identical proteins and their annotated locations for XP_011525544.1

    Related
    ENSP00000504008.1, ENST00000600196.2
    Conserved Domains (2) summary
    pfam00688
    Location:30262
    TGFb_propeptide; TGF-beta propeptide
    cd19384
    Location:293391
    TGF_beta_TGFB1; transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-1 (TGF-beta-1) and similar proteins
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