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Spdl1 spindle apparatus coiled-coil protein 1 [ Mus musculus (house mouse) ]

Gene ID: 70385, updated on 5-Mar-2024

Summary

Official Symbol
Spdl1provided by MGI
Official Full Name
spindle apparatus coiled-coil protein 1provided by MGI
Primary source
MGI:MGI:1917635
See related
Ensembl:ENSMUSG00000069910 AllianceGenome:MGI:1917635
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ccdc99; 1700018I02Rik; 2600001J17Rik; 2810049B11Rik
Summary
Predicted to enable enzyme binding activity and kinetochore binding activity. Predicted to be involved in several processes, including establishment of mitotic spindle orientation; mitotic metaphase plate congression; and protein localization to kinetochore. Predicted to act upstream of or within cell division. Predicted to be located in nucleus. Predicted to be part of outer kinetochore. Predicted to be active in spindle pole. Is expressed in several structures, including alimentary system; axial musculature; brain; liver lobe; and maturing glomerular tuft. Orthologous to human SPDL1 (spindle apparatus coiled-coil protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E11.5 (RPKM 8.5), liver E14 (RPKM 7.2) and 10 other tissues See more
Orthologs
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Genomic context

See Spdl1 in Genome Data Viewer
Location:
11 A4; 11 19.9 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (34700012..34724492, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (34809185..34833665, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene dedicator of cyto-kinesis 2 Neighboring gene predicted gene, 51858 Neighboring gene STARR-seq mESC enhancer starr_29152 Neighboring gene STARR-positive B cell enhancer ABC_E5215 Neighboring gene STARR-positive B cell enhancer ABC_E2983 Neighboring gene STARR-seq mESC enhancer starr_29153 Neighboring gene predicted gene, 53681 Neighboring gene STARR-positive B cell enhancer ABC_E3939 Neighboring gene predicted gene, 22022 Neighboring gene predicted gene, 25799

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables kinetochore binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables kinetochore binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of mitotic spindle orientation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in establishment of mitotic spindle orientation ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic metaphase chromosome alignment IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitotic metaphase chromosome alignment ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic spindle assembly checkpoint signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in protein localization to kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein localization to kinetochore ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in kinetochore IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of outer kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of outer kinetochore ISO
Inferred from Sequence Orthology
more info
 
is_active_in spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in spindle pole ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein Spindly
Names
coiled-coil domain containing 99
coiled-coil domain-containing protein 99
spindle apparatus coiled-coil domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027411.2NP_081687.2  protein Spindly

    See identical proteins and their annotated locations for NP_081687.2

    Status: VALIDATED

    Source sequence(s)
    AK139553, AK160143, BY712013, DV663229
    Consensus CDS
    CCDS24541.1
    UniProtKB/Swiss-Prot
    Q5DY45, Q923A2
    Related
    ENSMUSP00000090882.3, ENSMUST00000093191.3
    Conserved Domains (1) summary
    COG1196
    Location:1344
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    34700012..34724492 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534169.3XP_006534232.1  protein Spindly isoform X1

    See identical proteins and their annotated locations for XP_006534232.1

    UniProtKB/Swiss-Prot
    Q5DY45, Q923A2
    Conserved Domains (1) summary
    COG1196
    Location:1344
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
  2. XM_036156979.1XP_036012872.1  protein Spindly isoform X3

    Conserved Domains (1) summary
    TIGR02168
    Location:2281
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  3. XM_011249245.3XP_011247547.1  protein Spindly isoform X2

    Conserved Domains (1) summary
    COG1196
    Location:18283
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]