U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cox10 heme A:farnesyltransferase cytochrome c oxidase assembly factor 10 [ Mus musculus (house mouse) ]

Gene ID: 70383, updated on 17-Jul-2024

Summary

Official Symbol
Cox10provided by MGI
Official Full Name
heme A:farnesyltransferase cytochrome c oxidase assembly factor 10provided by MGI
Primary source
MGI:MGI:1917633
See related
Ensembl:ENSMUSG00000042148 AllianceGenome:MGI:1917633
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2410004F01Rik
Summary
Predicted to enable farnesyltranstransferase activity. Acts upstream of or within several processes, including cytochrome complex assembly; heme A biosynthetic process; and mitochondrial fission. Located in mitochondrion. Is expressed in alimentary system; nervous system; and respiratory system. Used to study Parkinson's disease; cytochrome-c oxidase deficiency disease; and mitochondrial myopathy. Human ortholog(s) of this gene implicated in cytochrome-c oxidase deficiency disease. Orthologous to human COX10 (cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 18.8), kidney adult (RPKM 13.0) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Cox10 in Genome Data Viewer
Location:
11 B3; 11 39.47 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (63853453..63970298, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (63962627..64079472, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_29740 Neighboring gene heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1 Neighboring gene STARR-positive B cell enhancer ABC_E1420 Neighboring gene STARR-seq mESC enhancer starr_29745 Neighboring gene STARR-seq mESC enhancer starr_29746 Neighboring gene RIKEN cDNA 9630013K17 gene Neighboring gene predicted gene, 30060 Neighboring gene predicted gene 12289 Neighboring gene predicted gene, 51866 Neighboring gene RIKEN cDNA 2810001G20 gene Neighboring gene STARR-seq mESC enhancer starr_29751 Neighboring gene STARR-seq mESC enhancer starr_29752 Neighboring gene STARR-seq mESC enhancer starr_29754 Neighboring gene predicted gene 12290

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (1)  1 citation

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables farnesyltranstransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables protoheme IX farnesyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protoheme IX farnesyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protoheme IX farnesyltransferase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity, transferring alkyl or aryl (other than methyl) groups IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within aerobic respiration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within copper ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cytochrome complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in heme A biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within heme A biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in heme A biosynthetic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within heme A biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in heme A biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in heme O biosynthetic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within heme biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in heme biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within leukocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within mitochondrial fission IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein farnesylation ISO
Inferred from Sequence Orthology
more info
 
involved_in respiratory chain complex IV assembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of cytochrome complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protoheme IX farnesyltransferase, mitochondrial
Names
COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase
cytochrome c oxidase assembly protein 10
heme O synthase
NP_848466.1
XP_006534231.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178379.3NP_848466.1  protoheme IX farnesyltransferase, mitochondrial

    See identical proteins and their annotated locations for NP_848466.1

    Status: VALIDATED

    Source sequence(s)
    AK149999, AL603889, BY078593
    Consensus CDS
    CCDS24839.1
    UniProtKB/Swiss-Prot
    Q8CFY5
    UniProtKB/TrEMBL
    Q3TAS4, Q3U3N1
    Related
    ENSMUSP00000040138.9, ENSMUST00000049091.9
    Conserved Domains (1) summary
    cd13957
    Location:159414
    PT_UbiA_Cox10; Protoheme IX farnesyltransferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    63853453..63970298 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534168.4XP_006534231.1  protoheme IX farnesyltransferase, mitochondrial isoform X1

    Conserved Domains (1) summary
    cd13957
    Location:1198
    PT_UbiA_Cox10; Protoheme IX farnesyltransferase