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Ica1l islet cell autoantigen 1-like [ Mus musculus (house mouse) ]

Gene ID: 70375, updated on 5-Mar-2024

Summary

Official Symbol
Ica1lprovided by MGI
Official Full Name
islet cell autoantigen 1-likeprovided by MGI
Primary source
MGI:MGI:1917625
See related
Ensembl:ENSMUSG00000026018 AllianceGenome:MGI:1917625
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Als2cr15; b2b3465Clo; 1700030B17Rik
Summary
Predicted to enable protein domain specific binding activity. Acts upstream of or within spermatid development. Located in acrosomal vesicle. Orthologous to human ICA1L (islet cell autoantigen 1 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 8.3), CNS E18 (RPKM 6.5) and 6 other tissues See more
Orthologs
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Genomic context

See Ica1l in Genome Data Viewer
Location:
1 C2; 1 30.45 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (60024955..60082646, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (59985796..60043481, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene bone morphogenetic protein receptor type 2 Neighboring gene STARR-seq mESC enhancer starr_01055 Neighboring gene STARR-positive B cell enhancer ABC_E5760 Neighboring gene family with sequence similarity 117, member B Neighboring gene arginyl-tRNA synthetase 2, mitochondrial pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr1:60073097-60073398 Neighboring gene STARR-seq mESC enhancer starr_01058 Neighboring gene STARR-seq mESC enhancer starr_01059 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:60154934-60155145 Neighboring gene WD repeat domain 12 Neighboring gene calcium response factor Neighboring gene predicted gene 15464

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (4)  1 citation

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in regulation of transport IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within spermatid development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in acrosomal vesicle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
islet cell autoantigen 1-like protein
Names
Ica69-related protein
amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 15
amyotrophic lateral sclerosis 2 chromosomal region candidate gene 15 protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001316694.2NP_001303623.1  islet cell autoantigen 1-like protein isoform a

    Status: VALIDATED

    Source sequence(s)
    AC125377
    Consensus CDS
    CCDS14987.1
    UniProtKB/Swiss-Prot
    Q3TY65, Q6AXB8, Q6PD23, Q8C0R6, Q9D9S5
    UniProtKB/TrEMBL
    A0A087WSM1
    Related
    ENSMUSP00000140520.2, ENSMUST00000191251.7
    Conserved Domains (2) summary
    pfam04629
    Location:254431
    ICA69; Islet cell autoantigen ICA69, C-terminal domain
    pfam06456
    Location:15242
    Arfaptin; Arfaptin-like domain
  2. NM_001316695.2NP_001303624.1  islet cell autoantigen 1-like protein isoform b

    Status: VALIDATED

    Source sequence(s)
    AC125377
    Related
    ENSMUST00000186970.2
    Conserved Domains (1) summary
    cl12013
    Location:1584
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  3. NM_001357296.2NP_001344225.1  islet cell autoantigen 1-like protein isoform a

    Status: VALIDATED

    Source sequence(s)
    AC125377
    Consensus CDS
    CCDS14987.1
    UniProtKB/Swiss-Prot
    Q3TY65, Q6AXB8, Q6PD23, Q8C0R6, Q9D9S5
    UniProtKB/TrEMBL
    A0A087WSM1
    Conserved Domains (2) summary
    pfam04629
    Location:254431
    ICA69; Islet cell autoantigen ICA69, C-terminal domain
    pfam06456
    Location:15242
    Arfaptin; Arfaptin-like domain
  4. NM_027407.5NP_081683.3  islet cell autoantigen 1-like protein isoform a

    See identical proteins and their annotated locations for NP_081683.3

    Status: VALIDATED

    Source sequence(s)
    AC125377
    Consensus CDS
    CCDS14987.1
    UniProtKB/Swiss-Prot
    Q3TY65, Q6AXB8, Q6PD23, Q8C0R6, Q9D9S5
    UniProtKB/TrEMBL
    A0A087WSM1
    Related
    ENSMUSP00000027172.7, ENSMUST00000027172.13
    Conserved Domains (2) summary
    pfam04629
    Location:254431
    ICA69; Islet cell autoantigen ICA69, C-terminal domain
    pfam06456
    Location:15242
    Arfaptin; Arfaptin-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    60024955..60082646 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153607.1XP_036009500.1  islet cell autoantigen 1-like protein isoform X7

    Conserved Domains (2) summary
    pfam04629
    Location:327365
    ICA69; Islet cell autoantigen ICA69, C-terminal domain
    cl12013
    Location:67269
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  2. XM_036153596.1XP_036009489.1  islet cell autoantigen 1-like protein isoform X1

    UniProtKB/TrEMBL
    A0A087WSM1
    Conserved Domains (2) summary
    pfam04629
    Location:276452
    ICA69; Islet cell autoantigen ICA69, C-terminal domain
    cl12013
    Location:67269
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  3. XM_030242893.2XP_030098753.1  islet cell autoantigen 1-like protein isoform X2

    UniProtKB/TrEMBL
    A0A087WSM1
    Conserved Domains (2) summary
    pfam04629
    Location:248425
    ICA69; Islet cell autoantigen ICA69, C-terminal domain
    pfam06456
    Location:15236
    Arfaptin; Arfaptin-like domain
  4. XM_036153605.1XP_036009498.1  islet cell autoantigen 1-like protein isoform X5

    UniProtKB/TrEMBL
    A0A087WSM1
    Conserved Domains (2) summary
    pfam04629
    Location:255414
    ICA69; Islet cell autoantigen ICA69, C-terminal domain
    cl12013
    Location:46248
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  5. XM_017312240.3XP_017167729.1  islet cell autoantigen 1-like protein isoform X5

    UniProtKB/TrEMBL
    A0A087WSM1
    Conserved Domains (2) summary
    pfam04629
    Location:255414
    ICA69; Islet cell autoantigen ICA69, C-terminal domain
    cl12013
    Location:46248
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  6. XM_011238597.4XP_011236899.1  islet cell autoantigen 1-like protein isoform X4

    See identical proteins and their annotated locations for XP_011236899.1

    UniProtKB/Swiss-Prot
    Q3TY65, Q6AXB8, Q6PD23, Q8C0R6, Q9D9S5
    UniProtKB/TrEMBL
    A0A087WSM1
    Conserved Domains (2) summary
    pfam04629
    Location:254431
    ICA69; Islet cell autoantigen ICA69, C-terminal domain
    pfam06456
    Location:15242
    Arfaptin; Arfaptin-like domain
  7. XM_006496270.3XP_006496333.1  islet cell autoantigen 1-like protein isoform X4

    See identical proteins and their annotated locations for XP_006496333.1

    UniProtKB/Swiss-Prot
    Q3TY65, Q6AXB8, Q6PD23, Q8C0R6, Q9D9S5
    UniProtKB/TrEMBL
    A0A087WSM1
    Conserved Domains (2) summary
    pfam04629
    Location:254431
    ICA69; Islet cell autoantigen ICA69, C-terminal domain
    pfam06456
    Location:15242
    Arfaptin; Arfaptin-like domain
  8. XM_017312238.2XP_017167727.1  islet cell autoantigen 1-like protein isoform X2

    UniProtKB/TrEMBL
    A0A087WSM1
    Conserved Domains (2) summary
    pfam04629
    Location:248425
    ICA69; Islet cell autoantigen ICA69, C-terminal domain
    pfam06456
    Location:15236
    Arfaptin; Arfaptin-like domain
  9. XM_006496272.3XP_006496335.1  islet cell autoantigen 1-like protein isoform X9

    See identical proteins and their annotated locations for XP_006496335.1

    Conserved Domains (2) summary
    pfam04629
    Location:150327
    ICA69; Islet cell autoantigen ICA69, C-terminal domain
    cl12013
    Location:1144
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  10. XM_036153597.1XP_036009490.1  islet cell autoantigen 1-like protein isoform X3

    UniProtKB/TrEMBL
    A0A087WSM1
    Conserved Domains (2) summary
    pfam04629
    Location:276435
    ICA69; Islet cell autoantigen ICA69, C-terminal domain
    cl12013
    Location:67269
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  11. XM_030242896.2XP_030098756.1  islet cell autoantigen 1-like protein isoform X8

    Conserved Domains (2) summary
    pfam04629
    Location:310344
    ICA69; Islet cell autoantigen ICA69, C-terminal domain
    cl12013
    Location:46248
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  12. XM_030242895.1XP_030098755.1  islet cell autoantigen 1-like protein isoform X6

    UniProtKB/TrEMBL
    A0A087WSM1
    Conserved Domains (2) summary
    pfam04629
    Location:248408
    ICA69; Islet cell autoantigen ICA69, C-terminal domain
    pfam06456
    Location:15236
    Arfaptin; Arfaptin-like domain
  13. XM_030242894.2XP_030098754.1  islet cell autoantigen 1-like protein isoform X5

    UniProtKB/TrEMBL
    A0A087WSM1
    Related
    ENSMUSP00000141103.2, ENSMUST00000189776.2
    Conserved Domains (2) summary
    pfam04629
    Location:255414
    ICA69; Islet cell autoantigen ICA69, C-terminal domain
    cl12013
    Location:46248
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  14. XM_030242898.2XP_030098758.1  islet cell autoantigen 1-like protein isoform X10

    Conserved Domains (1) summary
    cl12013
    Location:1584
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  15. XM_017312257.3XP_017167746.1  islet cell autoantigen 1-like protein isoform X10

    Conserved Domains (1) summary
    cl12013
    Location:1584
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  16. XM_030242897.2XP_030098757.1  islet cell autoantigen 1-like protein isoform X10

    Conserved Domains (1) summary
    cl12013
    Location:1584
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  17. XM_030242900.1XP_030098760.1  islet cell autoantigen 1-like protein isoform X10

    Conserved Domains (1) summary
    cl12013
    Location:1584
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  18. XM_017312256.2XP_017167745.1  islet cell autoantigen 1-like protein isoform X10

    Conserved Domains (1) summary
    cl12013
    Location:1584
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature