U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Steap1 six transmembrane epithelial antigen of the prostate 1 [ Mus musculus (house mouse) ]

Gene ID: 70358, updated on 8-Dec-2022

Summary

Official Symbol
Steap1provided by MGI
Official Full Name
six transmembrane epithelial antigen of the prostate 1provided by MGI
Primary source
MGI:MGI:1917608
See related
Ensembl:ENSMUSG00000015652 AllianceGenome:MGI:1917608
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Steap; Prss24; 2410007B19Rik
Summary
Predicted to enable metal ion binding activity and oxidoreductase activity. Predicted to act upstream of or within ion transport and iron ion homeostasis. Located in endosome and plasma membrane. Is expressed in central nervous system and retina. Orthologous to several human genes including STEAP1 (STEAP family member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in adrenal adult (RPKM 2.8), placenta adult (RPKM 2.5) and 23 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Steap1 in Genome Data Viewer
Location:
5 A1; 5 3.2 cM
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (5786322..5799317, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (5736322..5749317, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 69 Neighboring gene predicted gene, 40262 Neighboring gene six transmembrane epithelial antigen of prostate 2 Neighboring gene predicted gene, 46900 Neighboring gene heat shock protein 8 pseudogene Neighboring gene predicted gene, 38697

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
metalloreductase STEAP1
Names
six-transmembrane epithelial antigen of prostate 1
NP_081675.2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027399.3NP_081675.2  metalloreductase STEAP1

    See identical proteins and their annotated locations for NP_081675.2

    Status: VALIDATED

    Source sequence(s)
    AK010437, AK144312, DN176485
    Consensus CDS
    CCDS19077.1
    UniProtKB/Swiss-Prot
    Q6P8X4, Q9CWR7
    UniProtKB/TrEMBL
    Q3UNB9
    Related
    ENSMUSP00000015796.3, ENSMUST00000015796.9
    Conserved Domains (1) summary
    pfam01794
    Location:121264
    Ferric_reduct; Ferric reductase like transmembrane component

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    5786322..5799317 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)