Secisbp2l SECIS binding protein 2-like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Secisbp2lprovided by MGI
Official Full Name: SECIS binding protein 2-likeprovided by MGI
Primary source: MGI:MGI:1917604
See related: Ensembl:ENSMUSG00000035093 AllianceGenome:MGI:1917604
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: C630011I23; 3110001I20Rik
Summary: Predicted to enable mRNA 3'-UTR binding activity; ribonucleoprotein complex binding activity; and selenocysteine insertion sequence binding activity. Predicted to be involved in selenocysteine incorporation. Predicted to be part of ribonucleoprotein complex. Orthologous to human SECISBP2L (SECIS binding protein 2 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in lung adult (RPKM 11.1), cerebellum adult (RPKM 8.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2; 2 F1

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (125578906..125624790, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (125736986..125782870, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SECISBP2L-Mediated Selenoprotein Synthesis Is Essential for Autonomous Regulation of Oligodendrocyte Differentiation.
Title: SECISBP2L-Mediated Selenoprotein Synthesis Is Essential for Autonomous Regulation of Oligodendrocyte Differentiation.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Markers

AI504340 (e-PCR)
- UniSTS:164175

D2Dcr71 (e-PCR), detects polymorphism
- UniSTS:507630

Homology

Homologs of the Secisbp2l gene: The Secisbp2l gene is conserved in human, chimpanzee, Rhesus monkey, dog, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 495 organisms have orthologs with human gene Secisbp2l
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables mRNA 3'-UTR binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables ribonucleoprotein complex binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables selenocysteine insertion sequence binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Process	Evidence Code	Pubs
involved_in selenocysteine incorporation	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Component	Evidence Code	Pubs
part_of ribonucleoprotein complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

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Preferred Names: selenocysteine insertion sequence-binding protein 2-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001369056.1 → NP_001355985.1 selenocysteine insertion sequence-binding protein 2-like isoform 3

Status: VALIDATED

Source sequence(s)

AL844580

Conserved Domains (1) summary

pfam01248
Location:377 → 479

Ribosomal_L7Ae; Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
NM_177608.3 → NP_808276.2 selenocysteine insertion sequence-binding protein 2-like isoform 2

See identical proteins and their annotated locations for NP_808276.2

Status: VALIDATED

Source sequence(s)

AK049924, AL844580, CB289930, CB528069, CJ198024

Consensus CDS

CCDS38230.1

UniProtKB/TrEMBL

A2AQE2, Q8C7M0

Related

ENSMUSP00000055772.7, ENSMUST00000053699.13

Conserved Domains (1) summary

pfam01248
Location:700 → 802

Ribosomal_L7Ae; Ribosomal protein L7Ae/L30e/S12e/Gadd45 family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

125578906..125624790 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006500156.5 → XP_006500219.1 selenocysteine insertion sequence-binding protein 2-like isoform X1

Conserved Domains (1) summary

pfam01248
Location:589 → 691

Ribosomal_L7Ae; Ribosomal protein L7Ae/L30e/S12e/Gadd45 family

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_133725.1: Suppressed sequence

Description

NM_133725.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.