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TFF3 trefoil factor 3 [ Homo sapiens (human) ]

Gene ID: 7033, updated on 8-Dec-2018

Summary

Official Symbol
TFF3provided by HGNC
Official Full Name
trefoil factor 3provided by HGNC
Primary source
HGNC:HGNC:11757
See related
Ensembl:ENSG00000160180 MIM:600633
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ITF; P1B; TFI
Summary
Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. This gene is expressed in goblet cells of the intestines and colon. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008]
Expression
Biased expression in colon (RPKM 367.8), thyroid (RPKM 187.9) and 4 other tissues See more
Orthologs

Genomic context

See TFF3 in Genome Data Viewer
Location:
21q22.3
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 21 NC_000021.9 (42311667..42315596, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (43731777..43735706, complement)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene uromodulin like 1 Neighboring gene UMODL1 antisense RNA 1 Neighboring gene uncharacterized LOC105372814 Neighboring gene ATP binding cassette subfamily G member 1 Neighboring gene RNA, 5S ribosomal pseudogene 492 Neighboring gene uncharacterized LOC105372815 Neighboring gene trefoil factor 2 Neighboring gene trefoil factor 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
maintenance of gastrointestinal epithelium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of glucose metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
secretory granule IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
trefoil factor 3
Names
polypeptide P1.B
trefoil factor 3 (intestinal)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003226.3NP_003217.3  trefoil factor 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AF432265, AP001623, BC017859
    Consensus CDS
    CCDS33565.2
    UniProtKB/Swiss-Prot
    Q07654
    UniProtKB/TrEMBL
    A0A0A6YYJ4
    Related
    ENSP00000430690.1, ENST00000518498.1
    Conserved Domains (1) summary
    smart00018
    Location:4489
    PD; P or trefoil or TFF domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p12 Primary Assembly

    Range
    42311667..42315596 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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