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Pigw phosphatidylinositol glycan anchor biosynthesis, class W [ Mus musculus (house mouse) ]

Gene ID: 70325, updated on 11-Apr-2024

Summary

Official Symbol
Pigwprovided by MGI
Official Full Name
phosphatidylinositol glycan anchor biosynthesis, class Wprovided by MGI
Primary source
MGI:MGI:1917575
See related
Ensembl:ENSMUSG00000045140 AllianceGenome:MGI:1917575
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gwt1; PIG-W; 2610044A17Rik
Summary
Predicted to enable glucosaminyl-phosphatidylinositol O-acyltransferase activity. Predicted to be involved in GPI anchor biosynthetic process and protein localization to plasma membrane. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be integral component of membrane. Orthologous to human PIGW (phosphatidylinositol glycan anchor biosynthesis class W). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 2.4), liver E14.5 (RPKM 2.2) and 28 other tissues See more
Orthologs
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Genomic context

See Pigw in Genome Data Viewer
Location:
11 C; 11 51.34 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (84767139..84771111, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (84876313..84880285, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930502E09 gene Neighboring gene STARR-positive B cell enhancer ABC_E3986 Neighboring gene gametogenetin binding protein 2 Neighboring gene STARR-seq mESC enhancer starr_30226 Neighboring gene STARR-seq mESC enhancer starr_30227 Neighboring gene STARR-positive B cell enhancer ABC_E7033 Neighboring gene gametogenetin binding protein 2, opposite strand Neighboring gene myosin XIX Neighboring gene zinc finger, HIT type 3 Neighboring gene predicted gene, 33028 Neighboring gene predicted gene, 32917

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables glucosaminyl-phosphatidylinositol O-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in GPI anchor biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
phosphatidylinositol-glycan biosynthesis class W protein
Names
phosphatidylinositol glycan, class W

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077636.1NP_001071104.1  phosphatidylinositol-glycan biosynthesis class W protein

    See identical proteins and their annotated locations for NP_001071104.1

    Status: VALIDATED

    Source sequence(s)
    AK086537, CD547872
    Consensus CDS
    CCDS36263.1
    UniProtKB/Swiss-Prot
    Q8C398, Q8C4S0, Q9CSX1
    UniProtKB/TrEMBL
    B7ZN11
    Related
    ENSMUSP00000103715.3, ENSMUST00000108080.3
    Conserved Domains (1) summary
    cl02109
    Location:4502
    GWT1; GWT1
  2. NM_001363112.1NP_001350041.1  phosphatidylinositol-glycan biosynthesis class W protein

    Status: VALIDATED

    Source sequence(s)
    AL645623, BC144942
    Consensus CDS
    CCDS36263.1
    UniProtKB/Swiss-Prot
    Q8C398, Q8C4S0, Q9CSX1
    UniProtKB/TrEMBL
    B7ZN11
    Conserved Domains (1) summary
    cl02109
    Location:4502
    GWT1; GWT1
  3. NM_027388.2NP_081664.2  phosphatidylinositol-glycan biosynthesis class W protein

    See identical proteins and their annotated locations for NP_081664.2

    Status: VALIDATED

    Source sequence(s)
    AK086537, BB647852, CD547872
    Consensus CDS
    CCDS36263.1
    UniProtKB/Swiss-Prot
    Q8C398, Q8C4S0, Q9CSX1
    UniProtKB/TrEMBL
    B7ZN11
    Related
    ENSMUSP00000064547.3, ENSMUST00000067058.3
    Conserved Domains (1) summary
    cl02109
    Location:4502
    GWT1; GWT1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    84767139..84771111 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)