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Rabep2 rabaptin, RAB GTPase binding effector protein 2 [ Mus musculus (house mouse) ]

Gene ID: 70314, updated on 9-May-2024

Summary

Official Symbol
Rabep2provided by MGI
Official Full Name
rabaptin, RAB GTPase binding effector protein 2provided by MGI
Primary source
MGI:MGI:1917564
See related
Ensembl:ENSMUSG00000030727 AllianceGenome:MGI:1917564
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fra; 2610011A08Rik
Summary
Predicted to enable GTPase activator activity and growth factor activity. Predicted to be involved in regulation of cilium assembly. Predicted to act upstream of or within cell projection organization and protein transport. Predicted to be located in centrosome; ciliary basal body; and cytosol. Predicted to be active in intracellular membrane-bounded organelle. Orthologous to human RABEP2 (rabaptin, RAB GTPase binding effector protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 26.0), spleen adult (RPKM 24.6) and 28 other tissues See more
Orthologs
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Genomic context

See Rabep2 in Genome Data Viewer
Location:
7 F3; 7 69.03 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (126027596..126045079)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (126428423..126445907)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 interacting protein Neighboring gene STARR-seq mESC enhancer starr_20144 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:133540343-133540526 Neighboring gene STARR-positive B cell enhancer ABC_E8208 Neighboring gene STARR-positive B cell enhancer ABC_E9706 Neighboring gene CD19 antigen Neighboring gene STARR-positive B cell enhancer ABC_E9707 Neighboring gene ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:133618829-133619012 Neighboring gene SH2B adaptor protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E4975 Neighboring gene predicted gene, 46001

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC8300

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell projection organization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within endocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cilium assembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
rab GTPase-binding effector protein 2
Names
fos-related antigen
rabaptin-5beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030566.2NP_085043.2  rab GTPase-binding effector protein 2

    See identical proteins and their annotated locations for NP_085043.2

    Status: VALIDATED

    Source sequence(s)
    AK144836, BU514356, BY665800
    Consensus CDS
    CCDS21829.2
    UniProtKB/Swiss-Prot
    Q3UMK8, Q91WG2, Q99KN3
    UniProtKB/TrEMBL
    Q3TZJ2
    Related
    ENSMUSP00000102015.3, ENSMUST00000106407.9
    Conserved Domains (1) summary
    pfam09311
    Location:276531
    Rab5-bind; Rabaptin-like protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    126027596..126045079
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242980.2XP_030098840.1  rab GTPase-binding effector protein 2 isoform X1

    Conserved Domains (1) summary
    pfam09311
    Location:131386
    Rab5-bind; Rabaptin-like protein

RNA

  1. XR_378268.5 RNA Sequence