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TFF1 trefoil factor 1 [ Homo sapiens (human) ]

Gene ID: 7031, updated on 5-Jan-2022


Official Symbol
TFF1provided by HGNC
Official Full Name
trefoil factor 1provided by HGNC
Primary source
See related
Ensembl:ENSG00000160182 MIM:113710
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
pS2; BCEI; HPS2; HP1.A; pNR-2; D21S21
Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer, and affect healing of the epithelium. This gene, which is expressed in the gastric mucosa, has also been studied because of its expression in human tumors. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008]
Restricted expression toward stomach (RPKM 2677.9) See more
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Genomic context

See TFF1 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 21 NC_000021.9 (42362282..42366535, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (43782391..43786644, complement)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene trefoil factor 3 Neighboring gene uncharacterized LOC105372815 Neighboring gene trefoil factor 2 Neighboring gene transmembrane serine protease 3 Neighboring gene ubiquitin associated and SH3 domain containing A Neighboring gene RNA, U6 small nuclear 1149, pseudogene

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


GeneRIFs: Gene References Into Functions

What's a GeneRIF?


Associated conditions

Description Tests
Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations.
GeneReviews: Not available

Pathways from PubChem


Products Interactant Other Gene Complex Source Pubs Description

General gene information



Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
enables protein binding IPI
Inferred from Physical Interaction
more info
Process Evidence Code Pubs
involved_in carbohydrate metabolic process TAS
Traceable Author Statement
more info
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
involved_in maintenance of gastrointestinal epithelium IBA
Inferred from Biological aspect of Ancestor
more info
involved_in negative regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
involved_in response to immobilization stress IEA
Inferred from Electronic Annotation
more info
involved_in response to iron ion IEA
Inferred from Electronic Annotation
more info
involved_in response to peptide hormone IEA
Inferred from Electronic Annotation
more info
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
Component Evidence Code Pubs
located_in extracellular region TAS
Traceable Author Statement
more info
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info

General protein information

Preferred Names
trefoil factor 1
breast cancer estrogen-inducible protein
breast cancer estrogen-inducible sequence
gastrointestinal trefoil protein pS2
polypeptide P1.A
protein pS2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003225.3NP_003216.1  trefoil factor 1 precursor

    See identical proteins and their annotated locations for NP_003216.1

    Status: REVIEWED

    Source sequence(s)
    BC032811, BQ083523, BU539534
    Consensus CDS
    ENSP00000291527.2, ENST00000291527.3
    Conserved Domains (1) summary
    PD; P or trefoil or TFF domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly


  1. NC_000021.9 Reference GRCh38.p13 Primary Assembly

    42362282..42366535 complement
    GenBank, FASTA, Sequence Viewer (Graphics)
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