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Gcc2 GRIP and coiled-coil domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 70297, updated on 8-Nov-2022

Summary

Official Symbol
Gcc2provided by MGI
Official Full Name
GRIP and coiled-coil domain containing 2provided by MGI
Primary source
MGI:MGI:1917547
See related
Ensembl:ENSMUSG00000038039 AllianceGenome:MGI:1917547
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0336; 0610043A03Rik; 2210420P05Rik; 2600014C01Rik
Summary
Predicted to enable identical protein binding activity. Predicted to be involved in several processes, including microtubule cytoskeleton organization; protein localization to organelle; and retrograde transport, endosome to Golgi. Predicted to act upstream of or within protein transport. Predicted to be located in nucleoplasm and trans-Golgi network. Predicted to be active in Golgi apparatus. Orthologous to human GCC2 (GRIP and coiled-coil domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 5.2), frontal lobe adult (RPKM 5.1) and 28 other tissues See more
Orthologs
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Genomic context

See Gcc2 in Genome Data Viewer
Location:
10; 10 B4
Exon count:
24
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (58091217..58141421)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (58255408..58305599)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene 4981 Neighboring gene predicted gene 9919 Neighboring gene LIM and senescent cell antigen-like domains 1 Neighboring gene predicted gene, 23058 Neighboring gene RAN binding protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in Golgi ribbon formation ISO
Inferred from Sequence Orthology
more info
 
involved_in late endosome to Golgi transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in late endosome to Golgi transport ISO
Inferred from Sequence Orthology
more info
 
involved_in microtubule anchoring ISO
Inferred from Sequence Orthology
more info
 
involved_in microtubule organizing center organization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
involved_in protein targeting to lysosome ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in recycling endosome to Golgi transport ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein exit from endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
involved_in retrograde transport, endosome to Golgi ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
GRIP and coiled-coil domain-containing protein 2
Names
185 kDa Golgi coiled-coil protein
GCC185

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027375.3NP_081651.2  GRIP and coiled-coil domain-containing protein 2

    See identical proteins and their annotated locations for NP_081651.2

    Status: VALIDATED

    Source sequence(s)
    AC170751
    Consensus CDS
    CCDS23859.1
    UniProtKB/Swiss-Prot
    Q9CT45
    UniProtKB/TrEMBL
    B2RSU7, Q6P0A4
    Related
    ENSMUSP00000054033.8, ENSMUST00000057659.14
    Conserved Domains (4) summary
    TIGR02168
    Location:6241386
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01465
    Location:16101652
    GRIP; GRIP domain
    pfam07851
    Location:104203
    TMPIT; TMPIT-like protein
    pfam16704
    Location:15441608
    Rab_bind; Rab binding domain

RNA

  1. NR_176435.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC170751

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    58091217..58141421
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155993.1XP_036011886.1  GRIP and coiled-coil domain-containing protein 2 isoform X1

    Related
    ENSMUSP00000124152.2, ENSMUST00000162860.8
    Conserved Domains (4) summary
    COG1196
    Location:2271044
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:6541370
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam16704
    Location:14441508
    Rab_bind; Rab binding domain
    pfam01465
    Location:15101552
    GRIP; GRIP domain
  2. XM_036155994.1XP_036011887.1  GRIP and coiled-coil domain-containing protein 2 isoform X2

    Conserved Domains (4) summary
    COG1196
    Location:15274
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:165470
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam16704
    Location:544608
    Rab_bind; Rab binding domain
    pfam01465
    Location:610652
    GRIP; GRIP domain

RNA

  1. XR_004936270.1 RNA Sequence