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Tmem143 transmembrane protein 143 [ Mus musculus (house mouse) ]

Gene ID: 70209, updated on 5-Mar-2024

Summary

Official Symbol
Tmem143provided by MGI
Official Full Name
transmembrane protein 143provided by MGI
Primary source
MGI:MGI:1917459
See related
Ensembl:ENSMUSG00000002781 AllianceGenome:MGI:1917459
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2310076O21Rik
Summary
Acts upstream of or within hematopoietic progenitor cell differentiation. Located in mitochondrion. Orthologous to human TMEM143 (transmembrane protein 143). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in adrenal adult (RPKM 68.2), heart adult (RPKM 64.7) and 26 other tissues See more
Orthologs
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Genomic context

See Tmem143 in Genome Data Viewer
Location:
7 B3; 7 29.58 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (45546403..45566837)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45896991..45917413)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 Neighboring gene synaptogyrin 4 Neighboring gene STARR-positive B cell enhancer ABC_E1087 Neighboring gene STARR-positive B cell enhancer ABC_E8172 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:53178126-53178235 Neighboring gene STARR-positive B cell enhancer ABC_E6547 Neighboring gene STARR-positive B cell enhancer ABC_E873 Neighboring gene epithelial membrane protein 3 Neighboring gene outer dynein arm docking complex subunit 1 Neighboring gene ATP synthase, H+ transporting, mitochondrial F0 complex, subunit g pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within hematopoietic progenitor cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144801.2NP_659050.2  transmembrane protein 143

    See identical proteins and their annotated locations for NP_659050.2

    Status: VALIDATED

    Source sequence(s)
    AK039173, AK087636, BB666121, BB739600, BE946904
    Consensus CDS
    CCDS21269.1
    UniProtKB/Swiss-Prot
    Q8BHU3, Q8BI00, Q8BI09, Q8VD26
    UniProtKB/TrEMBL
    G3X9F4
    Related
    ENSMUSP00000070405.8, ENSMUST00000069772.16
    Conserved Domains (1) summary
    pfam12576
    Location:226348
    DUF3754; Protein of unknown function (DUF3754)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    45546403..45566837
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006541188.4XP_006541251.1  transmembrane protein 143 isoform X1

    UniProtKB/Swiss-Prot
    Q8BHU3, Q8BI00, Q8BI09, Q8VD26
    Conserved Domains (1) summary
    pfam12576
    Location:191313
    DUF3754; Protein of unknown function (DUF3754)
  2. XM_006541189.4XP_006541252.1  transmembrane protein 143 isoform X2

    Conserved Domains (1) summary
    pfam12576
    Location:119241
    DUF3754; Protein of unknown function (DUF3754)
  3. XM_036153430.1XP_036009323.1  transmembrane protein 143 isoform X3

    Conserved Domains (1) summary
    pfam12576
    Location:1123
    DUF3754; Protein of unknown function (DUF3754)
  4. XM_006541190.3XP_006541253.1  transmembrane protein 143 isoform X3

    Conserved Domains (1) summary
    pfam12576
    Location:1123
    DUF3754; Protein of unknown function (DUF3754)
  5. XM_036153429.1XP_036009322.1  transmembrane protein 143 isoform X3

    Conserved Domains (1) summary
    pfam12576
    Location:1123
    DUF3754; Protein of unknown function (DUF3754)

RNA

  1. XR_003946562.2 RNA Sequence

    Related
    ENSMUST00000209292.2