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Mllt3 myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3 [ Mus musculus (house mouse) ]

Gene ID: 70122, updated on 9-Mar-2023

Summary

Official Symbol
Mllt3provided by MGI
Official Full Name
myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3provided by MGI
Primary source
MGI:MGI:1917372
See related
Ensembl:ENSMUSG00000028496 AllianceGenome:MGI:1917372
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Af9; D4Ertd321e; 2210011H10Rik; 2610012I03Rik; 3830408D16Rik
Summary
Predicted to enable chromatin binding activity and lysine-acetylated histone binding activity. Acts upstream of or within anterior/posterior pattern specification; gene expression; and segment specification. Located in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and limb bud. Orthologous to human MLLT3 (MLLT3 super elongation complex subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in whole brain E14.5 (RPKM 9.1), CNS E14 (RPKM 9.1) and 26 other tissues See more
Orthologs
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Genomic context

See Mllt3 in Genome Data Viewer
Location:
4 C4; 4 41.06 cM
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (87688162..87951652, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (87769925..88033407, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene poly(A) binding protein interacting protein 2B pseudogene Neighboring gene predicted gene, 34180 Neighboring gene predicted gene, 34232 Neighboring gene focadhesin Neighboring gene microRNA 491 Neighboring gene 3-hydroxyacyl-CoA dehydratase 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables histone binding ISO
Inferred from Sequence Orthology
more info
 
enables lysine-acetylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables lysine-acetylated histone binding ISO
Inferred from Sequence Orthology
more info
 
enables modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription elongation factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of transcription elongation factor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein AF-9
Names
myeloid/lymphoid or mixed lineage-leukemia translocation to 3 homolog
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286158.2NP_001273087.1  protein AF-9 isoform 3

    See identical proteins and their annotated locations for NP_001273087.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate 5' exon structure, initiates translation at a downstream start codon and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. It encodes isoform 3, which is shorter than isoform 1.
    Source sequence(s)
    AL806533, AL929524
    Consensus CDS
    CCDS71418.1
    UniProtKB/TrEMBL
    A0A8C6HS98, Q9D2P1
    Related
    ENSMUSP00000129523.2, ENSMUST00000126353.8
    Conserved Domains (1) summary
    pfam17793
    Location:81133
    AHD; ANC1 homology domain (AHD)
  2. NM_001404955.1NP_001391884.1  protein AF-9 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL806533, AL831756, AL929524
  3. NM_001404956.1NP_001391885.1  protein AF-9 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL806533, AL831756, AL929524
  4. NM_001404957.1NP_001391886.1  protein AF-9 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL806533, AL831756, AL929524
  5. NM_001404958.1NP_001391887.1  protein AF-9 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL806533, AL929524
  6. NM_027326.4NP_081602.3  protein AF-9 isoform 1

    See identical proteins and their annotated locations for NP_081602.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL806533, AL831756, AL929524
    Consensus CDS
    CCDS38796.1
    UniProtKB/Swiss-Prot
    A2AM29, Q99MK4
    Related
    ENSMUSP00000077232.6, ENSMUST00000078090.12
    Conserved Domains (1) summary
    pfam03366
    Location:29109
    YEATS; YEATS family
  7. NM_029931.4NP_084207.2  protein AF-9 isoform 2

    See identical proteins and their annotated locations for NP_084207.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks several exons, uses an alternate 5' exon structure and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AL806533, AL929524
    Consensus CDS
    CCDS38797.1
    UniProtKB/TrEMBL
    Q3UIA3, Q9D2P1
    Related
    ENSMUSP00000128366.2, ENSMUST00000149357.8
    Conserved Domains (1) summary
    pfam17793
    Location:97157
    AHD; ANC1 homology domain (AHD)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    87688162..87951652 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030253772.2XP_030109632.1  protein AF-9 isoform X4

    Conserved Domains (1) summary
    pfam17793
    Location:305365
    AHD; ANC1 homology domain (AHD)
  2. XM_030253771.2XP_030109631.1  protein AF-9 isoform X2

    Conserved Domains (2) summary
    cd16906
    Location:1105
    YEATS_AF-9_like; YEATS domain found in ENL and AF-9-like proteins
    pfam17793
    Location:472532
    AHD; ANC1 homology domain (AHD)
  3. XM_036164412.1XP_036020305.1  protein AF-9 isoform X4

    Conserved Domains (1) summary
    pfam17793
    Location:305365
    AHD; ANC1 homology domain (AHD)
  4. XM_006538250.3XP_006538313.1  protein AF-9 isoform X1

    Conserved Domains (2) summary
    cd16906
    Location:6134
    YEATS_AF-9_like; YEATS domain found in ENL and AF-9-like proteins
    pfam17793
    Location:501561
    AHD; ANC1 homology domain (AHD)
  5. XM_030253773.1XP_030109633.1  protein AF-9 isoform X4

    Conserved Domains (1) summary
    pfam17793
    Location:305365
    AHD; ANC1 homology domain (AHD)
  6. XM_006538253.4XP_006538316.1  protein AF-9 isoform X4

    See identical proteins and their annotated locations for XP_006538316.1

    Conserved Domains (1) summary
    pfam17793
    Location:305365
    AHD; ANC1 homology domain (AHD)
  7. XM_036164411.1XP_036020304.1  protein AF-9 isoform X3

    Conserved Domains (1) summary
    cd16906
    Location:9137
    YEATS_AF-9_like; YEATS domain found in ENL and AF-9-like proteins