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Yars2 tyrosyl-tRNA synthetase 2 (mitochondrial) [ Mus musculus (house mouse) ]

Gene ID: 70120, updated on 26-Sep-2022

Summary

Official Symbol
Yars2provided by MGI
Official Full Name
tyrosyl-tRNA synthetase 2 (mitochondrial)provided by MGI
Primary source
MGI:MGI:1917370
See related
Ensembl:ENSMUSG00000022792 AllianceGenome:MGI:1917370
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
tyrRS; 2210023C10Rik
Summary
Predicted to enable several functions, including protein homodimerization activity; tyrosine binding activity; and tyrosine-tRNA ligase activity. Predicted to be involved in mitochondrial tyrosyl-tRNA aminoacylation. Predicted to act upstream of or within translation. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and respiratory system. Human ortholog(s) of this gene implicated in myopathy, lactic acidosis, and sideroblastic anemia 2. Orthologous to human YARS2 (tyrosyl-tRNA synthetase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 30.6), ovary adult (RPKM 17.1) and 28 other tissues See more
Orthologs
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Genomic context

See Yars2 in Genome Data Viewer
Location:
16; 16 A2
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (16120829..16127504)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (16302965..16309640)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene plakophilin 2 Neighboring gene ribosomal protein L30 pseudogene Neighboring gene dynamin 1-like Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables tRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables tyrosine binding ISO
Inferred from Sequence Orthology
more info
 
enables tyrosine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables tyrosine-tRNA ligase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in mitochondrial tyrosyl-tRNA aminoacylation ISO
Inferred from Sequence Orthology
more info
 
involved_in tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in tRNA aminoacylation ISO
Inferred from Sequence Orthology
more info
 
involved_in tRNA aminoacylation for protein translation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
 
involved_in tyrosyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
tyrosine--tRNA ligase, mitochondrial
NP_937889.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198246.2NP_937889.1  tyrosine--tRNA ligase, mitochondrial

    See identical proteins and their annotated locations for NP_937889.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes a functional protein.
    Source sequence(s)
    AC112943, AK083653, BC060295
    Consensus CDS
    CCDS27983.1
    UniProtKB/Swiss-Prot
    Q6PAH7, Q8BYL4
    UniProtKB/TrEMBL
    Q8BJJ2
    Related
    ENSMUSP00000055277.9, ENSMUST00000059955.15
    Conserved Domains (2) summary
    cd00805
    Location:69351
    TyrRS_core; catalytic core domain of tyrosinyl-tRNA synthetase
    PRK05912
    Location:37469
    PRK05912; tyrosyl-tRNA synthetase; Validated

RNA

  1. NR_038046.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC112943, AK138504
    Related
    ENSMUST00000159683.2

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    16120829..16127504
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)