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Sash1 SAM and SH3 domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 70097, updated on 19-Mar-2019

Summary

Official Symbol
Sash1provided by MGI
Official Full Name
SAM and SH3 domain containing 1provided by MGI
Primary source
MGI:MGI:1917347
See related
Ensembl:ENSMUSG00000015305
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0790; 1100001C18Rik; 2500002E12Rik; A330076K04Rik
Expression
Ubiquitous expression in lung adult (RPKM 10.4), subcutaneous fat pad adult (RPKM 8.3) and 28 other tissues See more
Orthologs

Genomic context

See Sash1 in Genome Data Viewer
Location:
10; 10 A1
Exon count:
26
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (8722217..9027745, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (8442017..8605868, complement)

Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105245105 Neighboring gene uronyl-2-sulfotransferase Neighboring gene predicted gene, 40600 Neighboring gene sterile alpha motif domain containing 5 Neighboring gene predicted gene 6150

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
mitogen-activated protein kinase kinase kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitogen-activated protein kinase kinase kinase binding ISO
Inferred from Sequence Orthology
more info
PubMed 
molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
PubMed 
protein C-terminus binding ISO
Inferred from Sequence Orthology
more info
PubMed 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
membrane IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
SAM and SH3 domain-containing protein 1
Names
putative adapter and scaffold protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175155.4NP_780364.3  SAM and SH3 domain-containing protein 1

    See identical proteins and their annotated locations for NP_780364.3

    Status: VALIDATED

    Source sequence(s)
    AJ507736, BY770549, CJ125950
    Consensus CDS
    CCDS23692.1
    UniProtKB/Swiss-Prot
    P59808
    UniProtKB/TrEMBL
    F8VQK5
    Related
    ENSMUSP00000015449.5, ENSMUST00000015449.5
    Conserved Domains (5) summary
    cd09492
    Location:11561225
    SAM_SASH1_repeat2; SAM domain of SASH1 proteins, repeat 2
    cd09559
    Location:627691
    SAM_SASH1_repeat1; SAM domain of SASH1 proteins, repeat 1
    smart00454
    Location:11611224
    SAM; Sterile alpha motif
    cd11967
    Location:550606
    SH3_SASH1; Src homology 3 domain of SAM And SH3 Domain Containing Protein 1
    pfam12485
    Location:394548
    SLY; Lymphocyte signaling adaptor protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

    Range
    8722217..9027745 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017314079.1XP_017169568.1  SAM and SH3 domain-containing protein 1 isoform X2

  2. XM_011243205.1XP_011241507.1  SAM and SH3 domain-containing protein 1 isoform X1

    Conserved Domains (5) summary
    cd09492
    Location:12271296
    SAM_SASH1_repeat2; SAM domain of SASH1 proteins, repeat 2
    cd09559
    Location:698762
    SAM_SASH1_repeat1; SAM domain of SASH1 proteins, repeat 1
    smart00454
    Location:12321295
    SAM; Sterile alpha motif
    cd11967
    Location:621677
    SH3_SASH1; Src homology 3 domain of SAM And SH3 Domain Containing Protein 1
    pfam12485
    Location:465619
    SLY; Lymphocyte signaling adaptor protein
  3. XM_006512837.2XP_006512900.1  SAM and SH3 domain-containing protein 1 isoform X3

    Conserved Domains (5) summary
    cd09492
    Location:11181187
    SAM_SASH1_repeat2; SAM domain of SASH1 proteins, repeat 2
    cd09559
    Location:589653
    SAM_SASH1_repeat1; SAM domain of SASH1 proteins, repeat 1
    smart00454
    Location:11231186
    SAM; Sterile alpha motif
    cd11967
    Location:512568
    SH3_SASH1; Src homology 3 domain of SAM And SH3 Domain Containing Protein 1
    pfam12485
    Location:356510
    SLY; Lymphocyte signaling adaptor protein
  4. XM_006512840.2XP_006512903.1  SAM and SH3 domain-containing protein 1 isoform X5

    Conserved Domains (5) summary
    cd09492
    Location:924993
    SAM_SASH1_repeat2; SAM domain of SASH1 proteins, repeat 2
    cd09559
    Location:395459
    SAM_SASH1_repeat1; SAM domain of SASH1 proteins, repeat 1
    smart00454
    Location:929992
    SAM; Sterile alpha motif
    cd11967
    Location:318374
    SH3_SASH1; Src homology 3 domain of SAM And SH3 Domain Containing Protein 1
    pfam12485
    Location:162316
    SLY; Lymphocyte signaling adaptor protein
  5. XM_006512839.3XP_006512902.1  SAM and SH3 domain-containing protein 1 isoform X4

    Conserved Domains (5) summary
    cd09492
    Location:9361005
    SAM_SASH1_repeat2; SAM domain of SASH1 proteins, repeat 2
    cd09559
    Location:407471
    SAM_SASH1_repeat1; SAM domain of SASH1 proteins, repeat 1
    smart00454
    Location:9411004
    SAM; Sterile alpha motif
    cd11967
    Location:330386
    SH3_SASH1; Src homology 3 domain of SAM And SH3 Domain Containing Protein 1
    pfam12485
    Location:174328
    SLY; Lymphocyte signaling adaptor protein
  6. XM_006512841.1XP_006512904.1  SAM and SH3 domain-containing protein 1 isoform X6

    Conserved Domains (5) summary
    cd09492
    Location:703772
    SAM_SASH1_repeat2; SAM domain of SASH1 proteins, repeat 2
    cd09559
    Location:174238
    SAM_SASH1_repeat1; SAM domain of SASH1 proteins, repeat 1
    smart00454
    Location:708771
    SAM; Sterile alpha motif
    cd11967
    Location:97153
    SH3_SASH1; Src homology 3 domain of SAM And SH3 Domain Containing Protein 1
    pfam12485
    Location:195
    SLY; Lymphocyte signaling adaptor protein
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