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Ube2q1 ubiquitin-conjugating enzyme E2Q family member 1 [ Mus musculus (house mouse) ]

Gene ID: 70093, updated on 18-Apr-2024

Summary

Official Symbol
Ube2q1provided by MGI
Official Full Name
ubiquitin-conjugating enzyme E2Q family member 1provided by MGI
Primary source
MGI:MGI:1917343
See related
Ensembl:ENSMUSG00000042572 AllianceGenome:MGI:1917343
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gtap; Ube2q; NICE-5; PRO3094; 1110002C01Rik; 2310012M18Rik
Summary
Enables ubiquitin conjugating enzyme activity. Acts upstream of or within several processes, including embryo implantation; prolactin secretion; and suckling behavior. Predicted to be located in cell projection and cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including 4-cell stage embryo; blastocyst; mammary gland; reproductive system; and spleen. Orthologous to human UBE2Q1 (ubiquitin conjugating enzyme E2 Q1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 15.4), CNS E11.5 (RPKM 14.9) and 28 other tissues See more
Orthologs
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Genomic context

Location:
3 F1; 3 39.19 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (89680905..89691304)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (89773609..89783997)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene adenosine deaminase, RNA-specific Neighboring gene cholinergic receptor nicotinic beta 2 subunit Neighboring gene RIKEN cDNA 4632404H12 gene Neighboring gene STARR-positive B cell enhancer ABC_E2082 Neighboring gene STARR-seq mESC enhancer starr_08252 Neighboring gene STARR-seq mESC enhancer starr_08253 Neighboring gene STARR-positive B cell enhancer ABC_E2083 Neighboring gene STARR-seq mESC enhancer starr_08257 Neighboring gene predicted gene 8969 Neighboring gene src homology 2 domain-containing transforming protein E Neighboring gene STARR-positive B cell enhancer ABC_E9217

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation
  • Gene trapped (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin conjugating enzyme activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
ubiquitin-conjugating enzyme E2 Q1
Names
E2 ubiquitin-conjugating enzyme Q1
galactosyl transferase-associated protein
ubiquitin carrier protein Q1
ubiquitin-conjugating enzyme E2Q (putative) 1
ubiquitin-protein ligase Q1
NP_081591.3
XP_036019192.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027315.4NP_081591.3  ubiquitin-conjugating enzyme E2 Q1

    See identical proteins and their annotated locations for NP_081591.3

    Status: VALIDATED

    Source sequence(s)
    AC102392
    Consensus CDS
    CCDS17517.1
    UniProtKB/Swiss-Prot
    Q29ST1, Q3UIY3, Q6P913, Q7TSS2, Q80UT5, Q8K2T0, Q9D7E1
    Related
    ENSMUSP00000037939.9, ENSMUST00000038356.13
    Conserved Domains (1) summary
    cd00195
    Location:253409
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    89680905..89691304
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163299.1XP_036019192.1  ubiquitin-conjugating enzyme E2 Q1 isoform X1

    Related
    ENSMUSP00000143422.2, ENSMUST00000196726.2
    Conserved Domains (1) summary
    cd00195
    Location:84240
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...