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TECTA tectorin alpha [ Homo sapiens (human) ]

Gene ID: 7007, updated on 3-Mar-2019

Summary

Official Symbol
TECTAprovided by HGNC
Official Full Name
tectorin alphaprovided by HGNC
Primary source
HGNC:HGNC:11720
See related
Ensembl:ENSG00000109927 MIM:602574
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DFNA8; DFNA12; DFNB21
Summary
The tectorial membrane is an extracellular matrix of the inner ear that contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia, and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals. Alpha-tectorin is one of the major noncollagenous components of the tectorial membrane. Mutations in the TECTA gene have been shown to be responsible for autosomal dominant nonsyndromic hearing impairment and a recessive form of sensorineural pre-lingual non-syndromic deafness. [provided by RefSeq, Jul 2008]
Expression
Broad expression in brain (RPKM 1.1), testis (RPKM 0.6) and 24 other tissues See more
Orthologs

Genomic context

See TECTA in Genome Data Viewer
Location:
11q23.3
Exon count:
23
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (121102666..121190806)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (120973375..121062202)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene glutamate ionotropic receptor kainate type subunit 4 Neighboring gene uncharacterized LOC101929208 Neighboring gene HNF4 motif-containing MPRA enhancer 256 Neighboring gene tubulin folding cofactor E like Neighboring gene uncharacterized LOC105369533 Neighboring gene uncharacterized LOC105369534

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
extracellular matrix structural constituent IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
 
sensory perception of sound IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
anchored component of membrane IEA
Inferred from Electronic Annotation
more info
 
collagen-containing extracellular matrix IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011633.1 RefSeqGene

    Range
    5001..93141
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005422.2NP_005413.2  alpha-tectorin precursor

    See identical proteins and their annotated locations for NP_005413.2

    Status: REVIEWED

    Source sequence(s)
    AP000646, AP000826
    Consensus CDS
    CCDS8434.1
    UniProtKB/Swiss-Prot
    O75443
    Related
    ENSP00000264037.2, ENST00000264037.2
    Conserved Domains (10) summary
    smart00216
    Location:703865
    VWD; von Willebrand factor (vWF) type D domain
    smart00241
    Location:18052057
    ZP; Zona pellucida (ZP) domain
    smart00539
    Location:98254
    NIDO; Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins
    smart00832
    Location:517591
    C8; This domain contains 8 conserved cysteine residues
    pfam00094
    Location:322478
    VWD; von Willebrand factor type D domain
    pfam00100
    Location:19372057
    Zona_pellucida; Zona pellucida-like domain
    pfam01826
    Location:597650
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:12981368
    C8; C8 domain
    pfam14670
    Location:20892121
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl17735
    Location:652706
    VWC; von Willebrand factor type C domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

    Range
    121102666..121190806
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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