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TEC tec protein tyrosine kinase [ Homo sapiens (human) ]

Gene ID: 7006, updated on 13-Mar-2020

Summary

Official Symbol
TECprovided by HGNC
Official Full Name
tec protein tyrosine kinaseprovided by HGNC
Primary source
HGNC:HGNC:11719
See related
Ensembl:ENSG00000135605 MIM:600583
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PSCTK4
Summary
The protein encoded by this gene belongs to the Tec family of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. Tec family kinases are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. They are also key players in the regulation of the immune functions. Tec kinase is an integral component of T cell signaling and has a distinct role in T cell activation. This gene may be associated with myelodysplastic syndrome. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 2.4), esophagus (RPKM 1.4) and 23 other tissues See more
Orthologs

Genomic context

See TEC in Genome Data Viewer
Location:
4p12-p11
Exon count:
21
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (48135783..48269864, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (48137800..48271814, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene NIPA like domain containing 1 Neighboring gene TXK tyrosine kinase Neighboring gene RNA, U6 small nuclear 838, pseudogene Neighboring gene uncharacterized LOC105374445 Neighboring gene SLAIN motif family member 2 Neighboring gene U6 snRNA-associated Sm-like protein LSm2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
NHGRI GWA Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef A cell-based bimolecular fluorescence complementation assay demonstrates that HIV-1 Nef interacts with the Tec family members Bmx, Btk, and Itk but not Tec or Txk. Mutation A96I in the Tec SH3 domain dramatically enhances interaction with Nef PubMed
Pr55(Gag) gag Tec kinase chemical inhibitors diminish the recruitment of ITK to the plasma membrane perturbing HIV-1 Gag-ITK co-localization, disrupting F-actin polymerization, and inhibiting HIV-1 release and replication PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126760, MGC126762

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
non-membrane spanning protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
phospholipid binding NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
B cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
B cell receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
Fc-epsilon receptor signaling pathway TAS
Traceable Author Statement
more info
 
T cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adaptive immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integrin-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
peptidyl-tyrosine autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-tyrosine autophosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation TAS
Traceable Author Statement
more info
PubMed 
regulation of platelet activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of platelet activation IDA
Inferred from Direct Assay
more info
PubMed 
tissue regeneration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
tyrosine-protein kinase Tec
NP_003206.2
XP_011512039.1
XP_011512043.1
XP_016864058.1
XP_024309961.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003215.3NP_003206.2  tyrosine-protein kinase Tec

    See identical proteins and their annotated locations for NP_003206.2

    Status: REVIEWED

    Source sequence(s)
    AC079118, AC098873, BC101713
    Consensus CDS
    CCDS3481.1
    UniProtKB/Swiss-Prot
    P42680
    Related
    ENSP00000370912.3, ENST00000381501.8
    Conserved Domains (4) summary
    cd10396
    Location:240346
    SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)
    cd11905
    Location:182237
    SH3_Tec; Src Homology 3 domain of Tec (Tyrosine kinase expressed in hepatocellular carcinoma)
    cd01238
    Location:7148
    PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
    cd05114
    Location:365624
    PTKc_Tec_Rlk; Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular carcinoma and Resting lymphocyte kinase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    48135783..48269864 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024454193.1XP_024309961.1  tyrosine-protein kinase Tec isoform X1

    Conserved Domains (4) summary
    cd10396
    Location:240346
    SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)
    cd11905
    Location:182237
    SH3_Tec; Src Homology 3 domain of Tec (Tyrosine kinase expressed in hepatocellular carcinoma)
    cd01238
    Location:7148
    PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
    cd05114
    Location:365624
    PTKc_Tec_Rlk; Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular carcinoma and Resting lymphocyte kinase
  2. XM_011513737.2XP_011512039.1  tyrosine-protein kinase Tec isoform X2

    See identical proteins and their annotated locations for XP_011512039.1

    Conserved Domains (5) summary
    cd10396
    Location:204310
    SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)
    cd11905
    Location:146201
    SH3_Tec; Src Homology 3 domain of Tec (Tyrosine kinase expressed in hepatocellular carcinoma)
    cd05114
    Location:329588
    PTKc_Tec_Rlk; Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular carcinoma and Resting lymphocyte kinase
    pfam07714
    Location:334583
    Pkinase_Tyr; Protein tyrosine kinase
    cl17171
    Location:11112
    PH-like; Pleckstrin homology-like domain
  3. XM_017008569.1XP_016864058.1  tyrosine-protein kinase Tec isoform X4

  4. XM_011513741.1XP_011512043.1  tyrosine-protein kinase Tec isoform X3

    Conserved Domains (5) summary
    cd10396
    Location:240346
    SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)
    cd11905
    Location:182237
    SH3_Tec; Src Homology 3 domain of Tec (Tyrosine kinase expressed in hepatocellular carcinoma)
    cd01238
    Location:7148
    PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
    pfam00169
    Location:5111
    PH; PH domain
    cl21453
    Location:365459
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_001741319.1 RNA Sequence

  2. XR_925160.2 RNA Sequence

  3. XR_001741318.1 RNA Sequence

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