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TEAD3 TEA domain transcription factor 3 [ Homo sapiens (human) ]

Gene ID: 7005, updated on 23-Nov-2021

Summary

Official Symbol
TEAD3provided by HGNC
Official Full Name
TEA domain transcription factor 3provided by HGNC
Primary source
HGNC:HGNC:11716
See related
Ensembl:ENSG00000007866 MIM:603170
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TEF5; TEAD5; TEF-5; DTEF-1; ETFR-1; TEAD-3
Summary
This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is predominantly expressed in the placenta and is involved in the transactivation of the chorionic somatomammotropin-B gene enhancer. Translation of this protein is initiated at a non-AUG (AUA) start codon. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in placenta (RPKM 22.4), endometrium (RPKM 21.2) and 23 other tissues See more
Orthologs
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Genomic context

See TEAD3 in Genome Data Viewer
Location:
6p21.31
Exon count:
14
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (35473597..35497079, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (35441374..35464856, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene FA complementation group E Neighboring gene ribosomal protein L10a Neighboring gene microRNA 7111 Neighboring gene VISTA enhancer hs1887 Neighboring gene TUB like protein 1 Neighboring gene uncharacterized LOC101929309 Neighboring gene ribosomal protein S15a pseudogene 19

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in asymmetric neuroblast division IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in embryonic organ development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in female pregnancy TAS
Traceable Author Statement
more info
PubMed 
involved_in hippo signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in hippo signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
transcriptional enhancer factor TEF-5
Names
TEA domain family member 3
TEA domain family member 5
transcriptional enhancer factor 5
transcriptional enhancer factor TEF-5 (DTEF-1)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395214.1NP_001382143.1  transcriptional enhancer factor TEF-5 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL022721, AL033519
    Conserved Domains (1) summary
    smart00426
    Location:3097
    TEA; TEA domain
  2. NM_003214.4NP_003205.2  transcriptional enhancer factor TEF-5 isoform 1

    See identical proteins and their annotated locations for NP_003205.2

    Status: REVIEWED

    Source sequence(s)
    BC027877, BC091488, DA856821
    Consensus CDS
    CCDS47414.1
    UniProtKB/Swiss-Prot
    Q99594
    Related
    ENSP00000345772.8, ENST00000338863.13
    Conserved Domains (1) summary
    smart00426
    Location:3097
    TEA; TEA domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    35473597..35497079 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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