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TEAD4 TEA domain transcription factor 4 [ Homo sapiens (human) ]

Gene ID: 7004, updated on 8-Jul-2018
Official Symbol
TEAD4provided by HGNC
Official Full Name
TEA domain transcription factor 4provided by HGNC
Primary source
HGNC:HGNC:11717
See related
Ensembl:ENSG00000197905 MIM:601714; Vega:OTTHUMG00000168153
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TEF3; RTEF1; TEF-3; EFTR-2; TEFR-1; TCF13L1; hRTEF-1B
Summary
This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is preferentially expressed in the skeletal muscle, and binds to the M-CAT regulatory element found in promoters of muscle-specific genes to direct their gene expression. Alternatively spliced transcripts encoding distinct isoforms, some of which are translated through the use of a non-AUG (UUG) initiation codon, have been described for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 4.8), placenta (RPKM 4.3) and 23 other tissues See more
Orthologs
See TEAD4 in Genome Data Viewer
Location:
12p13.33
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (2959312..3040676)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (3068478..3149842)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene tubby like protein 3 Neighboring gene RNA, U6 small nuclear 1315, pseudogene Neighboring gene ribosomal protein L13a pseudogene 24 Neighboring gene tetraspanin 9 Neighboring gene ribosomal protein S27 pseudogene 3

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Clinical, polysomnographic and genome-wide association analyses of narcolepsy with cataplexy: a European Narcolepsy Network study.
NHGRI GWA Catalog
  • Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem (from REACTOME)
    Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystemThe reactions involved in the metabolism of fatty acids and of the triacylglycerols and ketone bodies derived from them form a closely interrelated, coordinately regulated module that plays a central...
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
  • Hippo signaling, organism-specific biosystem (from KEGG)
    Hippo signaling, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
  • Hippo signaling, conserved biosystem (from KEGG)
    Hippo signaling, conserved biosystemFunctional set; Cellular processes; Cell signaling
  • Hippo signaling pathway, organism-specific biosystem (from KEGG)
    Hippo signaling pathway, organism-specific biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • Hippo signaling pathway, conserved biosystem (from KEGG)
    Hippo signaling pathway, conserved biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • Hippo signaling pathway -multiple species, organism-specific biosystem (from KEGG)
    Hippo signaling pathway -multiple species, organism-specific biosystemHippo signaling pathways control diverse aspects of cell proliferation, survival, and morphogenesis in eukaryotes. The core organization of these networks is conserved over a billion years of evoluti...
  • Hippo signaling pathway -multiple species, conserved biosystem (from KEGG)
    Hippo signaling pathway -multiple species, conserved biosystemHippo signaling pathways control diverse aspects of cell proliferation, survival, and morphogenesis in eukaryotes. The core organization of these networks is conserved over a billion years of evoluti...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
  • PPARA activates gene expression, organism-specific biosystem (from REACTOME)
    PPARA activates gene expression, organism-specific biosystemThe set of genes regulated by PPAR-alpha is not fully known in humans, however many examples have been found in mice. Genes directly activated by PPAR-alpha contain peroxisome proliferator receptor e...
  • Preimplantation Embryo, organism-specific biosystem (from WikiPathways)
    Preimplantation Embryo, organism-specific biosystemThe source of this pathway is RNA-Seq data from single-cell pre-implantation embryos (Supplemental Table 1): http://www.nature.com/nsmb/journal/v20/n9/full/nsmb.2660.html Analysis options for runnin...
  • Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystem (from REACTOME)
    Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystemPeroxisome proliferator-activated receptor alpha (PPAR-alpha) is the major regulator of fatty acid oxidation in the liver. PPARalpha is also the target of fibrate drugs used to treat abnormal plasma ...
  • YAP1- and WWTR1 (TAZ)-stimulated gene expression, organism-specific biosystem (from REACTOME)
    YAP1- and WWTR1 (TAZ)-stimulated gene expression, organism-specific biosystemYAP1 and WWTR1 (TAZ) are transcriptional co-activators, both homologues of the Drosophila Yorkie protein. They both interact with members of the TEAD family of transcription factors, and WWTR1 intera...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC9014

Gene Ontology Provided by GOA

Process Evidence Code Pubs
embryonic organ development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hippo signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hippo signaling IDA
Inferred from Direct Assay
more info
PubMed 
muscle organ development TAS
Traceable Author Statement
more info
PubMed 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
skeletal system development TAS
Traceable Author Statement
more info
PubMed 
transcription initiation from RNA polymerase II promoter TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Preferred Names
transcriptional enhancer factor TEF-3
Names
TEA domain family member 4
related transcription enhancer factor 1B
transcription factor 13-like 1
transcription factor RTEF-1
transcriptional enhancer factor 1-related
transcriptional enhancer factor 3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029958.1 RefSeqGene

    Range
    5001..86365
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003213.3NP_003204.2  transcriptional enhancer factor TEF-3 isoform 1

    See identical proteins and their annotated locations for NP_003204.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1), and initiates translation from a non-AUG (UUG) codon.
    Source sequence(s)
    BC015497, DA210894, U63824
    Consensus CDS
    CCDS31729.1
    UniProtKB/Swiss-Prot
    Q15561
    Related
    ENSP00000352926.2, OTTHUMP00000238122, ENST00000359864.6, OTTHUMT00000398475
    Conserved Domains (1) summary
    smart00426
    Location:38105
    TEA; TEA domain
  2. NM_201441.2NP_958849.1  transcriptional enhancer factor TEF-3 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame coding exon compared to variant 1, resulting in an isoform (2) that is missing an internal segment compared to isoform 1. It also initiates translation from a non-AUG (UUG) codon.
    Source sequence(s)
    AY101179, BM555991, DA210894, U63824
    Consensus CDS
    CCDS31730.1
    UniProtKB/Swiss-Prot
    Q15561
    Related
    ENSP00000351184.2, OTTHUMP00000238119, ENST00000358409.6, OTTHUMT00000398472
    Conserved Domains (1) summary
    smart00426
    Location:38105
    TEA; TEA domain
  3. NM_201443.2NP_958851.1  transcriptional enhancer factor TEF-3 isoform 3

    See identical proteins and their annotated locations for NP_958851.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks the exon containing the non-AUG (UUG) translation initiation codon compared to variant 1. It uses an in-frame, downstream AUG, resulting in an isoform (3) with a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    BX640921, DA886817, U63824
    Consensus CDS
    CCDS41737.1
    UniProtKB/Swiss-Prot
    Q15561
    Related
    ENSP00000380311.2, OTTHUMP00000238124, ENST00000397122.6, OTTHUMT00000398477

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

    Range
    2959312..3040676
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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