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FMR1 Fragile X messenger ribonucleoprotein 1 [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 700138, updated on 17-Aug-2024

Summary

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Official Symbol
FMR1provided by VGNC
Official Full Name
Fragile X messenger ribonucleoprotein 1provided by VGNC
Primary source
VGNC:VGNC:72687
See related
Ensembl:ENSMMUG00000015814
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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See FMR1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
18
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) X NC_041774.1 (143932009..143970686)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) X NC_027913.1 (141614593..141655932)

Chromosome X - NC_041774.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC106995351 Neighboring gene microRNA mir-514a Neighboring gene U6 spliceosomal RNA Neighboring gene FMR1 neighbor Neighboring gene HCLS1-associated protein X-1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables mRNA 3'-UTR binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables translation regulator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in anterograde axonal transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in central nervous system development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of translation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of translation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of alternative mRNA splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of dendrite morphogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of dendritic spine development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of filopodium assembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of mRNA stability IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of modification of synaptic structure IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of translation at postsynapse, modulating synaptic transmission IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in dendritic filopodium IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in dendritic spine IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in dendritic spine neck IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in growth cone IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in neuronal ribonucleoprotein granule IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in presynapse IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
synaptic functional regulator FMR1
Names
FMRP translational regulator 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041774.1 Reference Mmul_10 Primary Assembly

    Range
    143932009..143970686
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015128369.2 → XP_014983855.1  synaptic functional regulator FMR1 isoform X9

    UniProtKB/TrEMBL
    H9Z6Y7, I0FIR2
    Conserved Domains (5) summary
    pfam12235
    Location:399 → 469
    FXMRP1_C_core; Fragile X-related 1 protein core C terminal
    pfam16098
    Location:504 → 586
    FXMR_C2; Fragile X-related mental retardation protein C-terminal region 2
    cd20471
    Location:1 → 55
    Tudor_Agenet_FMR1_rpt1; first Tudor-like Agenet domain found in synaptic functional regulator FMR1 and similar proteins
    cd20474
    Location:58 → 120
    Tudor_Agenet_FMR1_rpt2; second Tudor-like Agenet domain found in synaptic functional regulator FMR1 and similar proteins
    cl00098
    Location:123 → 199
    KH-I; K homology (KH) RNA-binding domain, type I

  2. XM_015128359.2 → XP_014983845.1  synaptic functional regulator FMR1 isoform X1

    UniProtKB/TrEMBL
    H9ERS1, H9Z6Y4, I0FIR3
    Related
    ENSMMUP00000058618.1, ENSMMUT00000055789.2
    Conserved Domains (5) summary
    pfam12235
    Location:420 → 524
    FXMRP1_C_core; Fragile X-related 1 protein core C terminal
    pfam16098
    Location:550 → 632
    FXMR_C2; Fragile X-related mental retardation protein C-terminal region 2
    cd20471
    Location:1 → 55
    Tudor_Agenet_FMR1_rpt1; first Tudor-like Agenet domain found in synaptic functional regulator FMR1 and similar proteins
    cd20474
    Location:58 → 120
    Tudor_Agenet_FMR1_rpt2; second Tudor-like Agenet domain found in synaptic functional regulator FMR1 and similar proteins
    cl00098
    Location:123 → 199
    KH-I; K homology (KH) RNA-binding domain, type I

  3. XM_015128362.2 → XP_014983848.1  synaptic functional regulator FMR1 isoform X3

    UniProtKB/TrEMBL
    H9ERS1, H9Z6Y4
    Conserved Domains (7) summary
    pfam12235
    Location:420 → 524
    FXMRP1_C_core; Fragile X-related 1 protein core C terminal
    pfam16098
    Location:550 → 615
    FXMR_C2; Fragile X-related mental retardation protein C-terminal region 2
    cd20471
    Location:1 → 55
    Tudor_Agenet_FMR1_rpt1; first Tudor-like Agenet domain found in synaptic functional regulator FMR1 and similar proteins
    cd20474
    Location:58 → 120
    Tudor_Agenet_FMR1_rpt2; second Tudor-like Agenet domain found in synaptic functional regulator FMR1 and similar proteins
    cd22506
    Location:123 → 199
    KH_I_FMR1_rpt1; first type I K homology (KH) RNA-binding domain found in fragile X mental retardation protein 1 (FMR1) and similar proteins
    cd22509
    Location:218 → 280
    KH_I_FMR1_rpt2; second type I K homology (KH) RNA-binding domain found in fragile X mental retardation protein 1 (FMR1) and similar proteins
    cl00098
    Location:281 → 424
    KH-I; K homology (KH) RNA-binding domain, type I

  4. XM_015128360.2 → XP_014983846.1  synaptic functional regulator FMR1 isoform X2

    UniProtKB/TrEMBL
    H9ERS1, H9Z6Y4
    Conserved Domains (7) summary
    pfam12235
    Location:420 → 512
    FXMRP1_C_core; Fragile X-related 1 protein core C terminal
    pfam16098
    Location:538 → 620
    FXMR_C2; Fragile X-related mental retardation protein C-terminal region 2
    cd20471
    Location:1 → 55
    Tudor_Agenet_FMR1_rpt1; first Tudor-like Agenet domain found in synaptic functional regulator FMR1 and similar proteins
    cd20474
    Location:58 → 120
    Tudor_Agenet_FMR1_rpt2; second Tudor-like Agenet domain found in synaptic functional regulator FMR1 and similar proteins
    cd22506
    Location:123 → 199
    KH_I_FMR1_rpt1; first type I K homology (KH) RNA-binding domain found in fragile X mental retardation protein 1 (FMR1) and similar proteins
    cd22509
    Location:218 → 280
    KH_I_FMR1_rpt2; second type I K homology (KH) RNA-binding domain found in fragile X mental retardation protein 1 (FMR1) and similar proteins
    cl00098
    Location:281 → 424
    KH-I; K homology (KH) RNA-binding domain, type I

  5. XM_015128366.2 → XP_014983852.1  synaptic functional regulator FMR1 isoform X6

    UniProtKB/TrEMBL
    H9ERS1, H9Z6Y4
    Conserved Domains (7) summary
    pfam12235
    Location:420 → 512
    FXMRP1_C_core; Fragile X-related 1 protein core C terminal
    pfam16098
    Location:538 → 603
    FXMR_C2; Fragile X-related mental retardation protein C-terminal region 2
    cd20471
    Location:1 → 55
    Tudor_Agenet_FMR1_rpt1; first Tudor-like Agenet domain found in synaptic functional regulator FMR1 and similar proteins
    cd20474
    Location:58 → 120
    Tudor_Agenet_FMR1_rpt2; second Tudor-like Agenet domain found in synaptic functional regulator FMR1 and similar proteins
    cd22506
    Location:123 → 199
    KH_I_FMR1_rpt1; first type I K homology (KH) RNA-binding domain found in fragile X mental retardation protein 1 (FMR1) and similar proteins
    cd22509
    Location:218 → 280
    KH_I_FMR1_rpt2; second type I K homology (KH) RNA-binding domain found in fragile X mental retardation protein 1 (FMR1) and similar proteins
    cl00098
    Location:281 → 424
    KH-I; K homology (KH) RNA-binding domain, type I

  6. XM_015128364.2 → XP_014983850.1  synaptic functional regulator FMR1 isoform X5

    UniProtKB/TrEMBL
    H9Z6Y7
    Conserved Domains (7) summary
    pfam12235
    Location:420 → 490
    FXMRP1_C_core; Fragile X-related 1 protein core C terminal
    pfam16098
    Location:525 → 607
    FXMR_C2; Fragile X-related mental retardation protein C-terminal region 2
    cd20471
    Location:1 → 55
    Tudor_Agenet_FMR1_rpt1; first Tudor-like Agenet domain found in synaptic functional regulator FMR1 and similar proteins
    cd20474
    Location:58 → 120
    Tudor_Agenet_FMR1_rpt2; second Tudor-like Agenet domain found in synaptic functional regulator FMR1 and similar proteins
    cd22506
    Location:123 → 199
    KH_I_FMR1_rpt1; first type I K homology (KH) RNA-binding domain found in fragile X mental retardation protein 1 (FMR1) and similar proteins
    cd22509
    Location:218 → 280
    KH_I_FMR1_rpt2; second type I K homology (KH) RNA-binding domain found in fragile X mental retardation protein 1 (FMR1) and similar proteins
    cl00098
    Location:281 → 424
    KH-I; K homology (KH) RNA-binding domain, type I

  7. XM_015128368.2 → XP_014983854.1  synaptic functional regulator FMR1 isoform X8

    UniProtKB/TrEMBL
    H9Z6Y7
    Conserved Domains (7) summary
    pfam12235
    Location:420 → 490
    FXMRP1_C_core; Fragile X-related 1 protein core C terminal
    pfam16098
    Location:525 → 590
    FXMR_C2; Fragile X-related mental retardation protein C-terminal region 2
    cd20471
    Location:1 → 55
    Tudor_Agenet_FMR1_rpt1; first Tudor-like Agenet domain found in synaptic functional regulator FMR1 and similar proteins
    cd20474
    Location:58 → 120
    Tudor_Agenet_FMR1_rpt2; second Tudor-like Agenet domain found in synaptic functional regulator FMR1 and similar proteins
    cd22506
    Location:123 → 199
    KH_I_FMR1_rpt1; first type I K homology (KH) RNA-binding domain found in fragile X mental retardation protein 1 (FMR1) and similar proteins
    cd22509
    Location:218 → 280
    KH_I_FMR1_rpt2; second type I K homology (KH) RNA-binding domain found in fragile X mental retardation protein 1 (FMR1) and similar proteins
    cl00098
    Location:281 → 424
    KH-I; K homology (KH) RNA-binding domain, type I

  8. XM_028842440.1 → XP_028698273.1  synaptic functional regulator FMR1 isoform X11

    Conserved Domains (3) summary
    smart00322
    Location:221 → 280
    KH; K homology RNA-binding domain
    pfam00013
    Location:285 → 332
    KH_1; KH domain
    pfam05641
    Location:63 → 117
    Agenet; Agenet domain

  9. XM_028842441.1 → XP_028698274.1  synaptic functional regulator FMR1 isoform X12

    Conserved Domains (3) summary
    smart00322
    Location:221 → 280
    KH; K homology RNA-binding domain
    pfam00013
    Location:285 → 332
    KH_1; KH domain
    pfam05641
    Location:63 → 117
    Agenet; Agenet domain

  10. XM_015128363.2 → XP_014983849.1  synaptic functional regulator FMR1 isoform X4

    UniProtKB/TrEMBL
    H9ERN3, H9Z6Y6, I0FIR4
    Related
    ENSMMUP00000050476.1, ENSMMUT00000061414.2
    Conserved Domains (7) summary
    pfam12235
    Location:399 → 503
    FXMRP1_C_core; Fragile X-related 1 protein core C terminal
    pfam16098
    Location:529 → 611
    FXMR_C2; Fragile X-related mental retardation protein C-terminal region 2
    cd20471
    Location:1 → 55
    Tudor_Agenet_FMR1_rpt1; first Tudor-like Agenet domain found in synaptic functional regulator FMR1 and similar proteins
    cd20474
    Location:58 → 120
    Tudor_Agenet_FMR1_rpt2; second Tudor-like Agenet domain found in synaptic functional regulator FMR1 and similar proteins
    cd22506
    Location:123 → 199
    KH_I_FMR1_rpt1; first type I K homology (KH) RNA-binding domain found in fragile X mental retardation protein 1 (FMR1) and similar proteins
    cd22509
    Location:218 → 280
    KH_I_FMR1_rpt2; second type I K homology (KH) RNA-binding domain found in fragile X mental retardation protein 1 (FMR1) and similar proteins
    cd22512
    Location:281 → 403
    KH_I_FMR1_rpt3; third type I K homology (KH) RNA-binding domain found in fragile X mental retardation protein 1 (FMR1) and similar proteins

  11. XM_015128367.2 → XP_014983853.1  synaptic functional regulator FMR1 isoform X7

    UniProtKB/TrEMBL
    H9ERN3, H9Z6Y6
    Conserved Domains (5) summary
    pfam12235
    Location:399 → 503
    FXMRP1_C_core; Fragile X-related 1 protein core C terminal
    pfam16098
    Location:529 → 594
    FXMR_C2; Fragile X-related mental retardation protein C-terminal region 2
    cd20471
    Location:1 → 55
    Tudor_Agenet_FMR1_rpt1; first Tudor-like Agenet domain found in synaptic functional regulator FMR1 and similar proteins
    cd20474
    Location:58 → 120
    Tudor_Agenet_FMR1_rpt2; second Tudor-like Agenet domain found in synaptic functional regulator FMR1 and similar proteins
    cl00098
    Location:123 → 199
    KH-I; K homology (KH) RNA-binding domain, type I

  12. XM_015128370.2 → XP_014983856.1  synaptic functional regulator FMR1 isoform X10

    UniProtKB/TrEMBL
    H9Z6Y5
    Conserved Domains (5) summary
    pfam12235
    Location:399 → 491
    FXMRP1_C_core; Fragile X-related 1 protein core C terminal
    pfam16098
    Location:517 → 582
    FXMR_C2; Fragile X-related mental retardation protein C-terminal region 2
    cd20471
    Location:1 → 55
    Tudor_Agenet_FMR1_rpt1; first Tudor-like Agenet domain found in synaptic functional regulator FMR1 and similar proteins
    cd20474
    Location:58 → 120
    Tudor_Agenet_FMR1_rpt2; second Tudor-like Agenet domain found in synaptic functional regulator FMR1 and similar proteins
    cl00098
    Location:123 → 199
    KH-I; K homology (KH) RNA-binding domain, type I

  13. XM_028842442.1 → XP_028698275.1  synaptic functional regulator FMR1 isoform X13

    Conserved Domains (3) summary
    smart00322
    Location:221 → 280
    KH; K homology RNA-binding domain
    pfam00013
    Location:285 → 332
    KH_1; KH domain
    pfam05641
    Location:63 → 117
    Agenet; Agenet domain

  14. XM_028842443.1 → XP_028698276.1  synaptic functional regulator FMR1 isoform X14

    UniProtKB/TrEMBL
    H9Z6Y7
    Conserved Domains (6) summary
    pfam12235
    Location:420 → 490
    FXMRP1_C_core; Fragile X-related 1 protein core C terminal
    cd20471
    Location:1 → 55
    Tudor_Agenet_FMR1_rpt1; first Tudor-like Agenet domain found in synaptic functional regulator FMR1 and similar proteins
    cd20474
    Location:58 → 120
    Tudor_Agenet_FMR1_rpt2; second Tudor-like Agenet domain found in synaptic functional regulator FMR1 and similar proteins
    cd22506
    Location:123 → 199
    KH_I_FMR1_rpt1; first type I K homology (KH) RNA-binding domain found in fragile X mental retardation protein 1 (FMR1) and similar proteins
    cd22509
    Location:218 → 280
    KH_I_FMR1_rpt2; second type I K homology (KH) RNA-binding domain found in fragile X mental retardation protein 1 (FMR1) and similar proteins
    cl00098
    Location:281 → 424
    KH-I; K homology (KH) RNA-binding domain, type I
Nucleotide Protein
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