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IL7R interleukin 7 receptor [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 699869, updated on 10-Feb-2026
Official Symbol
IL7Rprovided by VGNC
Official Full Name
interleukin 7 receptorprovided by VGNC
Primary source
VGNC:VGNC:73735
See related
Ensembl:ENSMMUG00000001676
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
all
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See IL7R in Genome Data Viewer
Location:
chromosome: 6
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2025_08 current T2T-MMU8v2.0 (GCF_049350105.2) 6 NC_133411.1 (36908298..36931057)
103 previous assembly Mmul_10 (GCF_003339765.1) 6 NC_041759.1 (35634225..35656839)

Chromosome 6 - NC_133411.1Genomic Context describing neighboring genes Neighboring gene U7 small nuclear RNA Neighboring gene sperm flagellar 2 Neighboring gene zinc finger protein 862-like Neighboring gene uncharacterized LOC144341394 Neighboring gene calcyphosine like Neighboring gene uncharacterized LOC106998711

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Decreased number of CD4+ and CD8+ T cells that express the interleukin-7 receptor in blood and tissues of SIV-infected macaques. Moniuszko M, et al. Virology, 2006 Dec 5-20. PMID 16934309
  2. Increased (6 exon) interleukin-7 production after M. tuberculosis infection and soluble interleukin-7 receptor expression in lung tissue. Rane L, et al. Genes Immun, 2011 Oct. PMID 21677672
  3. Human CD4+ regulatory T cells express lower levels of the IL-7 receptor alpha chain (CD127), allowing consistent identification and sorting of live cells. Hartigan-O'Connor DJ, et al. J Immunol Methods, 2007 Jan 30. PMID 17173927
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the soluble IL-7R represents the dominant transcript in the lung tissue after M. tuberculosis infection.
    Title: Increased (6 exon) interleukin-7 production after M. tuberculosis infection and soluble interleukin-7 receptor expression in lung tissue.
  2. The CD4+CD25+CD127low phenotype is found to be characteristic of regulatory cells found in mice and in rhesus macaques.
    Title: Human CD4+ regulatory T cells express lower levels of the IL-7 receptor alpha chain (CD127), allowing consistent identification and sorting of live cells.
  3. We found that the percentage of T cells expressing IL-7R was significantly lower in both CD4(+) and CD8(+) T cell subsets blood and tissues in SIV-infected macaques than in healthy animals.
    Title: Decreased number of CD4+ and CD8+ T cells that express the interleukin-7 receptor in blood and tissues of SIV-infected macaques.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cytokine receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in hemopoiesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of receptor signaling pathway via JAK-STAT IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
interleukin-7 receptor subunit alpha

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RefSeqs of Annotated Genomes: GCF_049350105.2-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference T2T-MMU8v2.0

Genomic

  1. NC_133411.1 Reference T2T-MMU8v2.0

    Range
    36908298..36931057
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_078004658.1 → XP_077860784.1  interleukin-7 receptor subunit alpha isoform X2

    UniProtKB/TrEMBL
    A0A5F8AL00, F7G3H6

  2. XM_001092582.5 → XP_001092582.1  interleukin-7 receptor subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A1D5QDM4, A0A8J8XY80, G7MV35, H9YZ24
    Related
    ENSMMUP00000046143.1
    Conserved Domains (1) summary
    pfam00041
    Location:131 → 218
    fn3; Fibronectin type III domain
Nucleotide Protein
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Molecular Biology Databases
Research Materials