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Spink2 serine peptidase inhibitor, Kazal type 2 [ Mus musculus (house mouse) ]

Gene ID: 69982, updated on 12-Aug-2018

Summary

Official Symbol
Spink2provided by MGI
Official Full Name
serine peptidase inhibitor, Kazal type 2provided by MGI
Primary source
MGI:MGI:1917232
See related
Ensembl:ENSMUSG00000053030 Vega:OTTMUSG00000026576
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HUSI-II; AV038945; 1700007F22Rik
Expression
Restricted expression toward testis adult (RPKM 405.6) See more
Orthologs

Genomic context

See Spink2 in Genome Data Viewer
Location:
5; 5 C3.3
Exon count:
6
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (77205106..77216257, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (77634133..77640478, complement)

Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene cardiac hypertrophy associated epigenetic regulator 1 Neighboring gene predicted gene, 34598 Neighboring gene predicted gene, 19060 Neighboring gene RE1-silencing transcription factor Neighboring gene microRNA 5098

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 

General gene information

Markers

Homology

Clone Names

  • MGC107139

Gene Ontology Provided by MGI

Function Evidence Code Pubs
peptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
fertilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
male germ cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
male gonad development IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of serine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
seminiferous tubule development IMP
Inferred from Mutant Phenotype
more info
PubMed 
spermatid development IMP
Inferred from Mutant Phenotype
more info
PubMed 
spermatogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
acrosomal vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acrosomal vesicle IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
neuron projection IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serine protease inhibitor Kazal-type 2
Names
acrosin-trypsin inhibitor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289764.1NP_001276693.1  serine protease inhibitor Kazal-type 2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC165975
    Conserved Domains (1) summary
    pfam00050
    Location:4492
    Kazal_1; Kazal-type serine protease inhibitor domain
  2. NM_001289767.1NP_001276696.1  serine protease inhibitor Kazal-type 2 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 3, which is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AC165975
    Consensus CDS
    CCDS80306.1
    UniProtKB/TrEMBL
    D3Z3X9
    Related
    ENSMUSP00000113823.1, OTTMUSP00000032812, ENSMUST00000121825.1, OTTMUST00000065752
    Conserved Domains (1) summary
    pfam00050
    Location:1159
    Kazal_1; Kazal-type serine protease inhibitor domain
  3. NM_001289768.1NP_001276697.1  serine protease inhibitor Kazal-type 2 isoform 4 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding region and uses an alternate splice site in the central coding region, resulting in a frameshift and an early stop codon, compared to variant 1. It encodes isoform 4, which is shorter and has distinct N- and C-termini, compared to isoform 1.
    Source sequence(s)
    AK005709, AV380723, DV068802
    Consensus CDS
    CCDS80307.1
    UniProtKB/Swiss-Prot
    Q8BMY7
    UniProtKB/TrEMBL
    D3YTY0
    Related
    ENSMUSP00000112806.1, OTTMUSP00000032811, ENSMUST00000120429.7, OTTMUST00000065751
  4. NM_183284.3NP_899107.1  serine protease inhibitor Kazal-type 2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_899107.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon and initiates translation at an alternate start codon, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK005709, AV380723, DV068802
    Consensus CDS
    CCDS39121.1
    UniProtKB/Swiss-Prot
    Q8BMY7
    Related
    ENSMUSP00000067117.4, OTTMUSP00000032810, ENSMUST00000065216.10, OTTMUST00000065750
    Conserved Domains (1) summary
    pfam00050
    Location:3886
    Kazal_1; Kazal-type serine protease inhibitor domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

    Range
    77205106..77216257 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011249564.2XP_011247866.1  serine protease inhibitor Kazal-type 2 isoform X1

    Conserved Domains (1) summary
    pfam00050
    Location:4088
    Kazal_1; Kazal-type serine protease inhibitor domain
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