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Tmem30a transmembrane protein 30A [ Mus musculus (house mouse) ]

Gene ID: 69981, updated on 14-May-2024

Summary

Official Symbol
Tmem30aprovided by MGI
Official Full Name
transmembrane protein 30Aprovided by MGI
Primary source
MGI:MGI:106402
See related
Ensembl:ENSMUSG00000032328 AllianceGenome:MGI:106402
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cdc50a; D9Wsu20e; 2010200I23Rik
Summary
Predicted to enable aminophospholipid flippase activity. Involved in positive regulation of neuron projection development. Acts upstream of or within phospholipid translocation. Predicted to be located in cytoplasmic vesicle and membrane. Predicted to be integral component of membrane. Predicted to be part of phospholipid-translocating ATPase complex. Predicted to be active in Golgi apparatus; endoplasmic reticulum; and plasma membrane. Is expressed in extraembryonic component. Orthologous to human TMEM30A (transmembrane protein 30A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in frontal lobe adult (RPKM 34.3), cerebellum adult (RPKM 30.8) and 28 other tissues See more
Orthologs
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Genomic context

See Tmem30a in Genome Data Viewer
Location:
9 E1; 9 43.82 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (79676223..79700712, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (79768941..79793430, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_24746 Neighboring gene collagen, type XII, alpha 1 Neighboring gene STARR-seq mESC enhancer starr_24747 Neighboring gene STARR-positive B cell enhancer ABC_E2297 Neighboring gene predicted gene, 51685 Neighboring gene RIKEN cDNA 4930429F24 gene Neighboring gene cytochrome c oxidase subunit 7A2 Neighboring gene STARR-positive B cell enhancer ABC_E5090 Neighboring gene STARR-positive B cell enhancer ABC_E11416 Neighboring gene STARR-positive B cell enhancer ABC_E2298 Neighboring gene filamin A interacting protein 1 Neighboring gene predicted gene, 35261

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (4)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables aminophospholipid flippase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural molecule activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in early endosome membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in late endosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
part_of phospholipid-translocating ATPase complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cell cycle control protein 50A
Names
P4-ATPase flippase complex beta subunit TMEM30A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133718.4NP_598479.1  cell cycle control protein 50A

    See identical proteins and their annotated locations for NP_598479.1

    Status: VALIDATED

    Source sequence(s)
    AK077065, AK159364, BY470970
    Consensus CDS
    CCDS23367.1
    UniProtKB/Swiss-Prot
    Q3TCJ5, Q3UDH8, Q8R0X6, Q8VEH1, Q8VEK0
    UniProtKB/TrEMBL
    D3YVV1
    Related
    ENSMUSP00000034878.6, ENSMUST00000034878.12
    Conserved Domains (1) summary
    pfam03381
    Location:75353
    CDC50; LEM3 (ligand-effect modulator 3) family / CDC50 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    79676223..79700712 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)