U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Fars2 phenylalanine-tRNA synthetase 2 (mitochondrial) [ Mus musculus (house mouse) ]

Gene ID: 69955, updated on 26-Sep-2022

Summary

Official Symbol
Fars2provided by MGI
Official Full Name
phenylalanine-tRNA synthetase 2 (mitochondrial)provided by MGI
Primary source
MGI:MGI:1917205
See related
Ensembl:ENSMUSG00000021420 AllianceGenome:MGI:1917205
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fars1; pheRS
Summary
Predicted to enable phenylalanine-tRNA ligase activity and tRNA binding activity. Predicted to be involved in phenylalanyl-tRNA aminoacylation and tRNA processing. Predicted to act upstream of or within translation. Located in mitochondrion. Is expressed in several structures, including alimentary system; integumental system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 14 and hereditary spastic paraplegia 77. Orthologous to human FARS2 (phenylalanyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 22.0), heart adult (RPKM 16.0) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Fars2 in Genome Data Viewer
Location:
13; 13 A3.3
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (36301373..36721569)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (36117428..36537595)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory subunit 3G Neighboring gene predicted gene, 30127 Neighboring gene transmembrane p24 trafficking protein 10, pseudogene Neighboring gene predicted gene, 18132 Neighboring gene LYR motif containing 4 Neighboring gene predicted gene, 40912 Neighboring gene high mobility group box 1-like pseudogene Neighboring gene predicted gene, 46410

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • 2810431B21Rik, 6720478K01Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables phenylalanine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phenylalanine-tRNA ligase activity ISO
Inferred from Sequence Orthology
more info
 
enables tRNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in phenylalanyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phenylalanyl-tRNA aminoacylation ISO
Inferred from Sequence Orthology
more info
 
involved_in tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
 
involved_in tRNA processing ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
phenylalanine--tRNA ligase, mitochondrial
Names
phenylalanine-tRNA synthetase 1 (mitochondrial)
NP_001034278.1
NP_077236.1
XP_006516832.1
XP_006516833.1
XP_011242647.1
XP_030103262.1
XP_030103263.1
XP_030103264.1
XP_030103265.1
XP_030103266.1
XP_036014053.1
XP_036014054.1
XP_036014055.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039189.2NP_001034278.1  phenylalanine--tRNA ligase, mitochondrial isoform 2

    See identical proteins and their annotated locations for NP_001034278.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks part of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC121942, AK020164, AK076259, BY101501, BY290041
    Consensus CDS
    CCDS26454.1
    UniProtKB/TrEMBL
    G3X9Q4
    Related
    ENSMUSP00000097177.3, ENSMUST00000099582.4
    Conserved Domains (1) summary
    PLN02788
    Location:1218
    PLN02788; phenylalanine-tRNA synthetase
  2. NM_024274.3NP_077236.1  phenylalanine--tRNA ligase, mitochondrial isoform 1

    See identical proteins and their annotated locations for NP_077236.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC121942, AK020164, AK054370, AK076259, BY101501, BY290041
    Consensus CDS
    CCDS26453.1
    UniProtKB/Swiss-Prot
    Q99M01, Q9CYY0
    UniProtKB/TrEMBL
    A0A8C6HF29, Q8BW46
    Related
    ENSMUSP00000021857.6, ENSMUST00000021857.13
    Conserved Domains (1) summary
    PLN02788
    Location:32450
    PLN02788; phenylalanine-tRNA synthetase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    36301373..36721569
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158162.1XP_036014055.1  phenylalanine--tRNA ligase, mitochondrial isoform X3

    Related
    ENSMUSP00000153019.2, ENSMUST00000224916.2
    Conserved Domains (1) summary
    PLN02788
    Location:32407
    PLN02788; phenylalanine-tRNA synthetase
  2. XM_006516770.5XP_006516833.1  phenylalanine--tRNA ligase, mitochondrial isoform X2

    Conserved Domains (1) summary
    PLN02788
    Location:32406
    PLN02788; phenylalanine-tRNA synthetase
  3. XM_011244345.3XP_011242647.1  phenylalanine--tRNA ligase, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_011242647.1

    UniProtKB/Swiss-Prot
    Q99M01, Q9CYY0
    UniProtKB/TrEMBL
    A0A8C6HF29
    Related
    ENSMUSP00000153658.2, ENSMUST00000224611.2
    Conserved Domains (1) summary
    PLN02788
    Location:32450
    PLN02788; phenylalanine-tRNA synthetase
  4. XM_006516769.4XP_006516832.1  phenylalanine--tRNA ligase, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006516832.1

    UniProtKB/Swiss-Prot
    Q99M01, Q9CYY0
    UniProtKB/TrEMBL
    A0A8C6HF29
    Conserved Domains (1) summary
    PLN02788
    Location:32450
    PLN02788; phenylalanine-tRNA synthetase
  5. XM_030247405.1XP_030103265.1  phenylalanine--tRNA ligase, mitochondrial isoform X4

    UniProtKB/TrEMBL
    G3X9Q4
    Conserved Domains (1) summary
    PLN02788
    Location:1218
    PLN02788; phenylalanine-tRNA synthetase
  6. XM_030247404.1XP_030103264.1  phenylalanine--tRNA ligase, mitochondrial isoform X4

    UniProtKB/TrEMBL
    G3X9Q4
    Conserved Domains (1) summary
    PLN02788
    Location:1218
    PLN02788; phenylalanine-tRNA synthetase
  7. XM_030247406.2XP_030103266.1  phenylalanine--tRNA ligase, mitochondrial isoform X4

    UniProtKB/TrEMBL
    G3X9Q4
    Conserved Domains (1) summary
    PLN02788
    Location:1218
    PLN02788; phenylalanine-tRNA synthetase
  8. XM_030247402.2XP_030103262.1  phenylalanine--tRNA ligase, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q9CYY0
    UniProtKB/TrEMBL
    A0A8C6HF29
    Conserved Domains (1) summary
    PLN02788
    Location:32450
    PLN02788; phenylalanine-tRNA synthetase
  9. XM_030247403.2XP_030103263.1  phenylalanine--tRNA ligase, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q9CYY0
    UniProtKB/TrEMBL
    A0A8C6HF29
    Related
    ENSMUSP00000153628.2, ENSMUST00000224241.2
    Conserved Domains (1) summary
    PLN02788
    Location:32450
    PLN02788; phenylalanine-tRNA synthetase
  10. XM_036158160.1XP_036014053.1  phenylalanine--tRNA ligase, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q9CYY0
    UniProtKB/TrEMBL
    A0A8C6HF29
    Conserved Domains (1) summary
    PLN02788
    Location:32450
    PLN02788; phenylalanine-tRNA synthetase
  11. XM_036158161.1XP_036014054.1  phenylalanine--tRNA ligase, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q9CYY0
    UniProtKB/TrEMBL
    A0A8C6HF29
    Conserved Domains (1) summary
    PLN02788
    Location:32450
    PLN02788; phenylalanine-tRNA synthetase