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Exoc1 exocyst complex component 1 [ Mus musculus (house mouse) ]

Gene ID: 69940, updated on 24-Jan-2023

Summary

Official Symbol
Exoc1provided by MGI
Official Full Name
exocyst complex component 1provided by MGI
Primary source
MGI:MGI:2445020
See related
Ensembl:ENSMUSG00000036435 AllianceGenome:MGI:2445020
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SEC3; Sec3p; Sec3l1; 2810407P21Rik; A730011E05Rik
Summary
Predicted to enable phosphatidylinositol-4,5-bisphosphate binding activity. Acts upstream of or within embryo implantation. Predicted to be located in cytoplasm and cytoplasmic side of apical plasma membrane. Predicted to be part of exocyst. Predicted to be active in plasma membrane. Orthologous to human EXOC1 (exocyst complex component 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 16.5), CNS E14 (RPKM 14.7) and 28 other tissues See more
Orthologs
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Genomic context

See Exoc1 in Genome Data Viewer
Location:
5 C3.3; 5
Exon count:
21
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (76677147..76718145)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (76529307..76570298)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34175 Neighboring gene neuromedin U Neighboring gene exocyst complex component 1 like Neighboring gene centrosomal protein 135 Neighboring gene capping protein inhibiting regulator of actin Neighboring gene uncharacterized LOC118567351 Neighboring gene ribosomal protein L23a pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables phosphatidylinositol-4,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in Golgi to plasma membrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within embryo implantation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in membrane fission NAS
Non-traceable Author Statement
more info
PubMed 
involved_in mitotic cytokinesis NAS
Non-traceable Author Statement
more info
PubMed 
involved_in phosphatidylinositol-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein secretion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in vesicle docking involved in exocytosis NAS
Non-traceable Author Statement
more info
PubMed 
involved_in vesicle tethering involved in exocytosis NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic side of apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of exocyst IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of exocyst NAS
Non-traceable Author Statement
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
exocyst complex component 1
Names
SEC3-like 1
exocyst complex component Sec3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289770.2NP_001276699.1  exocyst complex component 1 isoform 2

    See identical proteins and their annotated locations for NP_001276699.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two alternate in-frame exons and contains another alternate in-frame exon compared to variant 4. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 4.
    Source sequence(s)
    AC127332
    Consensus CDS
    CCDS71607.1
    UniProtKB/Swiss-Prot
    E9QQ24, Q8R3S6
    UniProtKB/TrEMBL
    Q6P1Y9
    Related
    ENSMUSP00000084373.5, ENSMUST00000087133.11
    Conserved Domains (2) summary
    cd14683
    Location:3120
    PH-EXOC1; PH-like domain of Exocyst complex component 1
    pfam09763
    Location:184871
    Sec3_C; Exocyst complex component Sec3
  2. NM_001289771.2NP_001276700.1  exocyst complex component 1 isoform 3

    See identical proteins and their annotated locations for NP_001276700.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons compared to variant 4. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 4.
    Source sequence(s)
    AC127332
    Consensus CDS
    CCDS71608.1
    UniProtKB/TrEMBL
    Q5PPR2, Q6P1Y9
    Related
    ENSMUSP00000046719.7, ENSMUST00000049469.13
    Conserved Domains (2) summary
    cd14683
    Location:3120
    PH-EXOC1; PH-like domain of Exocyst complex component 1
    pfam09763
    Location:184856
    Sec3_C; Exocyst complex component Sec3
  3. NM_001359370.2NP_001346299.1  exocyst complex component 1 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) encodes the longest isoform (4).
    Source sequence(s)
    AC127332
    Conserved Domains (2) summary
    cd14683
    Location:3120
    PH-EXOC1; PH-like domain of Exocyst complex component 1
    pfam09763
    Location:191881
    Sec3_C; Exocyst complex component Sec3
  4. NM_001359372.2NP_001346301.1  exocyst complex component 1 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate in-frame exon compared to variant 4. The resulting isoform (5) has the same N- and C-termini but is shorter compared to isoform 4.
    Source sequence(s)
    AC127332
    Conserved Domains (2) summary
    cd14683
    Location:3120
    PH-EXOC1; PH-like domain of Exocyst complex component 1
    pfam09763
    Location:191863
    Sec3_C; Exocyst complex component Sec3
  5. NM_001359373.1NP_001346302.1  exocyst complex component 1 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 3' UTR and coding sequence compared to variant 4. The resulting isoform (6) has a shorter and distinct C-terminus compared to isoform 4.
    Source sequence(s)
    AC127332, AK042620
    Related
    ENSMUST00000137018.8
    Conserved Domains (1) summary
    cd14683
    Location:3120
    PH-EXOC1; PH-like domain of Exocyst complex component 1
  6. NM_001401325.1NP_001388254.1  exocyst complex component 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC127332
  7. NM_001401326.1NP_001388255.1  exocyst complex component 1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC127332
  8. NM_027270.3NP_081546.1  exocyst complex component 1 isoform 1

    See identical proteins and their annotated locations for NP_081546.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks an alternate in-frame exon and contains another alternate in-frame exon compared to variant 4. The resulting isoform (1) has the same N- and C-termini but is shorter compared to isoform 4.
    Source sequence(s)
    AC127332
    Consensus CDS
    CCDS39117.1
    UniProtKB/TrEMBL
    Q6P1Y9
    Related
    ENSMUSP00000109121.2, ENSMUST00000113493.8
    Conserved Domains (2) summary
    cd14683
    Location:3120
    PH-EXOC1; PH-like domain of Exocyst complex component 1
    pfam09763
    Location:191878
    Sec3_C; Exocyst complex component Sec3

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    76677147..76718145
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165480.1XP_036021373.1  exocyst complex component 1 isoform X3

    Conserved Domains (2) summary
    cd14683
    Location:3120
    PH-EXOC1; PH-like domain of Exocyst complex component 1
    pfam09763
    Location:184889
    Sec3_C; Exocyst complex component Sec3
  2. XM_036165478.1XP_036021371.1  exocyst complex component 1 isoform X1

    Conserved Domains (2) summary
    cd14683
    Location:3120
    PH-EXOC1; PH-like domain of Exocyst complex component 1
    pfam09763
    Location:195900
    Sec3_C; Exocyst complex component Sec3
  3. XM_036165481.1XP_036021374.1  exocyst complex component 1 isoform X4

    Conserved Domains (2) summary
    cd14683
    Location:3120
    PH-EXOC1; PH-like domain of Exocyst complex component 1
    pfam09763
    Location:195885
    Sec3_C; Exocyst complex component Sec3
  4. XM_036165479.1XP_036021372.1  exocyst complex component 1 isoform X2

    Conserved Domains (2) summary
    cd14683
    Location:3120
    PH-EXOC1; PH-like domain of Exocyst complex component 1
    pfam09763
    Location:191896
    Sec3_C; Exocyst complex component Sec3
  5. XM_036165484.1XP_036021377.1  exocyst complex component 1 isoform X7

    Conserved Domains (1) summary
    cl19950
    Location:25512
    Sec3_C; Exocyst complex component Sec3
  6. XM_036165485.1XP_036021378.1  exocyst complex component 1 isoform X7

    Conserved Domains (1) summary
    cl19950
    Location:25512
    Sec3_C; Exocyst complex component Sec3
  7. XM_036165482.1XP_036021375.1  exocyst complex component 1 isoform X5

    Conserved Domains (2) summary
    cd14683
    Location:3120
    PH-EXOC1; PH-like domain of Exocyst complex component 1
    pfam09763
    Location:195882
    Sec3_C; Exocyst complex component Sec3
  8. XM_036165483.1XP_036021376.1  exocyst complex component 1 isoform X6

    Conserved Domains (2) summary
    cd14683
    Location:3120
    PH-EXOC1; PH-like domain of Exocyst complex component 1
    pfam09763
    Location:195867
    Sec3_C; Exocyst complex component Sec3
  9. XM_036165486.1XP_036021379.1  exocyst complex component 1 isoform X8

    Conserved Domains (1) summary
    cl19950
    Location:6494
    Sec3_C; Exocyst complex component Sec3
  10. XM_036165487.1XP_036021380.1  exocyst complex component 1 isoform X9

    Conserved Domains (1) summary
    cl19950
    Location:6479
    Sec3_C; Exocyst complex component Sec3