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DYNLT1 dynein light chain Tctex-type 1 [ Homo sapiens (human) ]

Gene ID: 6993, updated on 10-Oct-2019

Summary

Official Symbol
DYNLT1provided by HGNC
Official Full Name
dynein light chain Tctex-type 1provided by HGNC
Primary source
HGNC:HGNC:11697
See related
Ensembl:ENSG00000146425 MIM:601554
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CW-1; TCTEL1; tctex-1
Summary
This gene encodes a component of the motor complex, cytoplasmic dynein, which transports cellular cargo along microtubules in the cell. The encoded protein regulates the length of primary cilia which are sensory organelles found on the surface of cells. The protein encoded by this gene interacts with viral proteins, like the minor capsid protein L2 of human papillomavirus, and is required for dynein-mediated delivery of the viral nucleic acid to the host nucleus. This protein interacts with oncogenic nucleoporins to disrupt gene regulation and cause leukemic transformation. Pseudogenes of this gene are present on chromosomes 4 and 17. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]
Expression
Ubiquitous expression in testis (RPKM 62.3), colon (RPKM 58.0) and 25 other tissues See more
Orthologs

Genomic context

See DYNLT1 in Genome Data Viewer
Location:
6q25.3
Exon count:
5
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (158636474..158644743, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (159057506..159065804, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene calcyclin binding protein pseudogene 3 Neighboring gene transmembrane protein 181 Neighboring gene TatD DNase domain containing 2 pseudogene 2 Neighboring gene microRNA 7161 Neighboring gene synaptotagmin like 3 Neighboring gene archaelysin family metallopeptidase 2 pseudogene 2 Neighboring gene microRNA 3918

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr interacts with DYNLT1 (HIV-1 Vpr F72L mutant has impaired interaction with DYNLT1) PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC111571

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
motor activity IEA
Inferred from Electronic Annotation
more info
 
protein C-terminus binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
axon development IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
dendrite development IEA
Inferred from Electronic Annotation
more info
 
establishment of mitotic spindle orientation ISS
Inferred from Sequence or Structural Similarity
more info
 
intracellular transport of viral protein in host cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
microtubule-dependent intracellular transport of viral material towards nucleus IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell death IEA
Inferred from Electronic Annotation
more info
 
negative regulation of mitochondrial membrane permeability IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neurogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
neuron projection morphogenesis IEA
Inferred from Electronic Annotation
more info
 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
positive regulation of Rac protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neuron projection development IEA
Inferred from Electronic Annotation
more info
 
regulation of G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
viral entry into host cell IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
axonal growth cone IEA
Inferred from Electronic Annotation
more info
 
cell IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic dynein complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic dynein complex ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasmic microtubule IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
 
host cell IEA
Inferred from Electronic Annotation
more info
 
lamellipodium IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
secretory granule lumen TAS
Traceable Author Statement
more info
 
secretory vesicle IDA
Inferred from Direct Assay
more info
PubMed 
spindle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
dynein light chain Tctex-type 1
Names
T-complex testis-specific protein 1 homolog
t-complex-associated-testis-expressed 1-like 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291602.2NP_001278531.1  dynein light chain Tctex-type 1 isoform 2

    See identical proteins and their annotated locations for NP_001278531.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    BU675683, HY017024, HY171700
    Conserved Domains (1) summary
    pfam03645
    Location:597
    Tctex-1; Tctex-1 family
  2. NM_001291603.2NP_001278532.1  dynein light chain Tctex-type 1 isoform 3

    See identical proteins and their annotated locations for NP_001278532.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region which results in a frameshift compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AL589931, AL591025, BU675683, DN915418, HY017024, HY171700
    Conserved Domains (1) summary
    pfam03645
    Location:1764
    Tctex-1; Tctex-1 family
  3. NM_006519.4NP_006510.1  dynein light chain Tctex-type 1 isoform 1

    See identical proteins and their annotated locations for NP_006510.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL589931, BC105588, BU675683, HY171700
    Consensus CDS
    CCDS5257.1
    UniProtKB/Swiss-Prot
    P63172
    Related
    ENSP00000356056.3, ENST00000367089.8
    Conserved Domains (1) summary
    pfam03645
    Location:17111
    Tctex-1; Tctex-1 family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    158636474..158644743 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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