Format

Send to:

Choose Destination

DYNLT1 dynein light chain Tctex-type 1 [ Homo sapiens (human) ]

Gene ID: 6993, updated on 22-Aug-2021

Summary

Official Symbol
DYNLT1provided by HGNC
Official Full Name
dynein light chain Tctex-type 1provided by HGNC
Primary source
HGNC:HGNC:11697
See related
Ensembl:ENSG00000146425 MIM:601554
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CW-1; TCTEL1; TCTEX1; tctex-1
Summary
This gene encodes a component of the motor complex, cytoplasmic dynein, which transports cellular cargo along microtubules in the cell. The encoded protein regulates the length of primary cilia which are sensory organelles found on the surface of cells. The protein encoded by this gene interacts with viral proteins, like the minor capsid protein L2 of human papillomavirus, and is required for dynein-mediated delivery of the viral nucleic acid to the host nucleus. This protein interacts with oncogenic nucleoporins to disrupt gene regulation and cause leukemic transformation. Pseudogenes of this gene are present on chromosomes 4 and 17. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]
Expression
Ubiquitous expression in testis (RPKM 62.3), colon (RPKM 58.0) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See DYNLT1 in Genome Data Viewer
Location:
6q25.3
Exon count:
5
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (158636474..158644743, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (159057506..159065775, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 10808 Neighboring gene transmembrane protein 181 Neighboring gene TatD DNase domain containing 2 pseudogene 2 Neighboring gene microRNA 7161 Neighboring gene synaptotagmin like 3 Neighboring gene AMZ2 pseudogene 2 Neighboring gene microRNA 3918

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr interacts with DYNLT1 (HIV-1 Vpr F72L mutant has impaired interaction with DYNLT1) PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC111571

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables dynein intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein C-terminus binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in axon development IEA
Inferred from Electronic Annotation
more info
 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in dendrite development IEA
Inferred from Electronic Annotation
more info
 
involved_in establishment of mitotic spindle orientation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in intracellular transport of viral protein in host cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in microtubule-dependent intracellular transport of viral material towards nucleus IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell death IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of mitochondrial membrane permeability IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of neurogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in neuron projection morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of Rac protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of neuron projection development IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
involved_in viral entry into host cell IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in axonal growth cone IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of cytoplasmic dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of cytoplasmic dynein complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of cytoplasmic dynein complex ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytoplasmic microtubule IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
 
located_in host cell IEA
Inferred from Electronic Annotation
more info
 
located_in lamellipodium IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
located_in secretory granule lumen TAS
Traceable Author Statement
more info
 
located_in secretory vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in spindle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
dynein light chain Tctex-type 1
Names
T-complex testis-specific protein 1 homolog
t-complex-associated-testis-expressed 1-like 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291602.2NP_001278531.1  dynein light chain Tctex-type 1 isoform 2

    See identical proteins and their annotated locations for NP_001278531.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    BU675683, HY017024, HY171700
    Conserved Domains (1) summary
    cd21462
    Location:899
    DLC-like_DYNLT1; dynein light chain (DLC)-like domain found in dynein light chain Tctex-type 1 (DYNLT1) and similar proteins
  2. NM_001291603.2NP_001278532.1  dynein light chain Tctex-type 1 isoform 3

    See identical proteins and their annotated locations for NP_001278532.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region which results in a frameshift compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AL589931, AL591025, BU675683, DN915418, HY017024, HY171700
    Conserved Domains (1) summary
    pfam03645
    Location:1664
    Tctex-1; Tctex-1 family
  3. NM_006519.4NP_006510.1  dynein light chain Tctex-type 1 isoform 1

    See identical proteins and their annotated locations for NP_006510.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL589931, BC105588, BU675683, HY171700
    Consensus CDS
    CCDS5257.1
    UniProtKB/Swiss-Prot
    P63172
    Related
    ENSP00000356056.3, ENST00000367089.8
    Conserved Domains (1) summary
    cd21462
    Location:12113
    DLC-like_DYNLT1; dynein light chain (DLC)-like domain found in dynein light chain Tctex-type 1 (DYNLT1) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    158636474..158644743 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center