U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Dnah17 dynein, axonemal, heavy chain 17 [ Mus musculus (house mouse) ]

Gene ID: 69926, updated on 9-Mar-2023

Summary

Official Symbol
Dnah17provided by MGI
Official Full Name
dynein, axonemal, heavy chain 17provided by MGI
Primary source
MGI:MGI:1917176
See related
Ensembl:ENSMUSG00000033987 AllianceGenome:MGI:1917176
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm1178; Dnahc17; Dnahcl1; mKIAA3028; 2810003K23Rik
Summary
Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Predicted to be involved in cilium movement and outer dynein arm assembly. Predicted to be located in sperm flagellum. Predicted to be part of outer dynein arm. Predicted to be active in axoneme and motile cilium. Used to study spermatogenic failure 39. Human ortholog(s) of this gene implicated in spermatogenic failure 39. Orthologous to human DNAH17 (dynein axonemal heavy chain 17). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 14.0), thymus adult (RPKM 1.2) and 1 other tissue See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Dnah17 in Genome Data Viewer
Location:
11; 11 E2
Exon count:
83
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (117912549..118021684, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (118021723..118130719, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene suppressor of cytokine signaling 3 Neighboring gene phosphatidylglycerophosphate synthase 1 Neighboring gene microRNA 6933 Neighboring gene predicted gene, 38514 Neighboring gene cytohesin 1 Neighboring gene VISTA enhancer mm1622

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (2)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables dynein intermediate chain binding IEA
Inferred from Electronic Annotation
more info
 
enables dynein light intermediate chain binding IEA
Inferred from Electronic Annotation
more info
 
enables minus-end-directed microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cilium movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in microtubule-based movement IEA
Inferred from Electronic Annotation
more info
 
involved_in outer dynein arm assembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in axoneme IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in axoneme ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cilium IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
part_of dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
is_active_in motile cilium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of outer dynein arm ISM
Inferred from Sequence Model
more info
PubMed 
part_of outer dynein arm ISO
Inferred from Sequence Orthology
more info
 
located_in sperm flagellum ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
dynein axonemal heavy chain 17; dynein heavy chain 17, axonemal
Names
axonemal beta dynein heavy chain 17
ciliary dynein heavy chain 17
dynein, axonemal, heavy like 1
dynein, axonemal, heavy polypeptide 17

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001167746.1NP_001161218.1  dynein axonemal heavy chain 17

    Status: VALIDATED

    Source sequence(s)
    AL591204, AL591433
    Consensus CDS
    CCDS48994.1
    UniProtKB/TrEMBL
    E9Q7P0
    Related
    ENSMUSP00000081864.6, ENSMUST00000084803.12
    Conserved Domains (6) summary
    pfam03028
    Location:37504443
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08385
    Location:185764
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:12651669
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12777
    Location:30273370
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:33973610
    AAA_9; ATP-binding dynein motor region D5
    cl21455
    Location:24002671
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    117912549..118021684 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534150.5XP_006534213.1  dynein heavy chain 17, axonemal isoform X1

    UniProtKB/TrEMBL
    A2A520
    Related
    ENSMUSP00000120542.3, ENSMUST00000132685.9
    Conserved Domains (7) summary
    COG5245
    Location:14934124
    DYN1; Dynein, heavy chain [Cytoskeleton]
    pfam12777
    Location:30403383
    MT; Microtubule-binding stalk of dynein motor
    pfam08385
    Location:187764
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:12661672
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12774
    Location:18062132
    AAA_6; Hydrolytic ATP binding site of dynein motor region D1
    pfam12780
    Location:27683027
    AAA_8; P-loop containing dynein motor region D4
    pfam18199
    Location:41624457
    Dynein_C; Dynein heavy chain C-terminal domain
  2. XM_006534151.4XP_006534214.1  dynein heavy chain 17, axonemal isoform X2

    Conserved Domains (7) summary
    COG5245
    Location:9793610
    DYN1; Dynein, heavy chain [Cytoskeleton]
    pfam12777
    Location:25262869
    MT; Microtubule-binding stalk of dynein motor
    pfam08385
    Location:2250
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:7521158
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12774
    Location:12921618
    AAA_6; Hydrolytic ATP binding site of dynein motor region D1
    pfam12780
    Location:22542513
    AAA_8; P-loop containing dynein motor region D4
    pfam18199
    Location:36483943
    Dynein_C; Dynein heavy chain C-terminal domain
  3. XM_006534152.4XP_006534215.1  dynein heavy chain 17, axonemal isoform X3

    Conserved Domains (5) summary
    pfam08385
    Location:187764
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:12661672
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12774
    Location:18062132
    AAA_6; Hydrolytic ATP binding site of dynein motor region D1
    pfam17852
    Location:22912408
    Dynein_AAA_lid; Dynein heavy chain AAA lid domain
    cl38936
    Location:21202255
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RNA

  1. XR_388524.5 RNA Sequence