U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Vrk2 vaccinia related kinase 2 [ Mus musculus (house mouse) ]

Gene ID: 69922, updated on 26-Sep-2022

Summary

Official Symbol
Vrk2provided by MGI
Official Full Name
vaccinia related kinase 2provided by MGI
Primary source
MGI:MGI:1917172
See related
Ensembl:ENSMUSG00000064090 AllianceGenome:MGI:1917172
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2810003O05Rik
Summary
Enables protein serine/threonine kinase activity. Acts upstream of or within protein autophosphorylation. Located in endoplasmic reticulum; membrane; and nuclear envelope. Is expressed in several structures, including cerebral cortex; dorsal mesogastrium; gonad; hemolymphoid system; and yolk sac. Orthologous to human VRK2 (VRK serine/threonine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14 (RPKM 6.6), liver E14.5 (RPKM 4.9) and 24 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Vrk2 in Genome Data Viewer
Location:
11; 11 A3.3
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (26421398..26544006, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (26471398..26594012, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 22868 Neighboring gene transmembrane protein 85 pseudogene Neighboring gene Fanconi anemia, complementation group L Neighboring gene VISTA enhancer mm57 Neighboring gene peptidylprolyl isomerase A pseudogene 11_266.1 Neighboring gene VISTA enhancer mm1555

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cellular response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of interleukin-1-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase VRK2
Names
vaccinia virus BIR kinase related kinase 2
NP_001239376.1
NP_081536.2
XP_006514864.1
XP_011242050.1
XP_030102151.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252447.1NP_001239376.1  serine/threonine-protein kinase VRK2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment in the C-terminal region, compared to isoform 1.
    Source sequence(s)
    AC083815, AL929272
    UniProtKB/Swiss-Prot
    Q8BN21
    Conserved Domains (2) summary
    pfam00069
    Location:29292
    Pkinase; Protein kinase domain
    cl21453
    Location:16314
    PKc_like; Protein Kinases, catalytic domain
  2. NM_027260.3NP_081536.2  serine/threonine-protein kinase VRK2 isoform 1

    See identical proteins and their annotated locations for NP_081536.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AF513620, BB852723, BE984366
    Consensus CDS
    CCDS24486.1
    UniProtKB/Swiss-Prot
    Q8BN21, Q9CZF9
    Related
    ENSMUSP00000077471.7, ENSMUST00000078362.13
    Conserved Domains (1) summary
    cl21453
    Location:16314
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    26421398..26544006 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514801.5XP_006514864.1  serine/threonine-protein kinase VRK2 isoform X1

    See identical proteins and their annotated locations for XP_006514864.1

    UniProtKB/Swiss-Prot
    Q8BN21, Q9CZF9
    Related
    ENSMUSP00000105130.2, ENSMUST00000109504.8
    Conserved Domains (1) summary
    cl21453
    Location:16314
    PKc_like; Protein Kinases, catalytic domain
  2. XM_030246291.1XP_030102151.1  serine/threonine-protein kinase VRK2 isoform X2

    Conserved Domains (2) summary
    PTZ00449
    Location:182370
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cl21453
    Location:1196
    PKc_like; Protein Kinases, catalytic domain
  3. XM_011243748.3XP_011242050.1  serine/threonine-protein kinase VRK2 isoform X2

    Conserved Domains (2) summary
    PTZ00449
    Location:182370
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cl21453
    Location:1196
    PKc_like; Protein Kinases, catalytic domain