Polr2i polymerase (RNA) II (DNA directed) polypeptide I [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Polr2iprovided by MGI
Official Full Name: polymerase (RNA) II (DNA directed) polypeptide Iprovided by MGI
Primary source: MGI:MGI:1917170
See related: Ensembl:ENSMUSG00000019738 AllianceGenome:MGI:1917170
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2810002B19Rik
Summary: Predicted to enable nucleic acid binding activity and zinc ion binding activity. Predicted to contribute to DNA-directed 5'-3' RNA polymerase activity. Predicted to be involved in maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; and transcription-coupled nucleotide-excision repair. Predicted to be located in nucleoplasm. Predicted to be part of RNA polymerase II, core complex. Is expressed in several structures, including alimentary system; blastocyst; integumental system; nervous system; and urinary system. Orthologous to human POLR2I (RNA polymerase II subunit I). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 84.8), whole brain E14.5 (RPKM 58.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7; 7 B1

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (29931499..29932812)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (30232074..30233387)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH139378 (e-PCR)
- UniSTS:221464

D1Bda12 (e-PCR)
- UniSTS:239759

Polr2i (e-PCR), detects polymorphism
- UniSTS:547289

Homology

Homologs of the Polr2i gene: The Polr2i gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, rice, and frog.
Orthologs from Annotation Pipeline: 446 organisms have orthologs with human gene Polr2i
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to DNA-directed 5'-3' RNA polymerase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in mRNA cleavage	IEA Inferred from Electronic Annotation more info
involved_in maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in transcription initiation at RNA polymerase II promoter	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in transcription-coupled nucleotide-excision repair	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Component	Evidence Code	Pubs
part_of DNA-directed RNA polymerase complex	IEA Inferred from Electronic Annotation more info
part_of RNA polymerase II, core complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of RNA polymerase II, core complex	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: DNA-directed RNA polymerase II subunit RPB9

Names: DNA-directed RNA polymerase II subunit I; RNA polymerase II 14.5 kDa subunit; RNA polymerase II subunit B9; RPB14.5

NP_081535.1

EC 2.7.7.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027259.1 → NP_081535.1 DNA-directed RNA polymerase II subunit RPB9

See identical proteins and their annotated locations for NP_081535.1

Status: PROVISIONAL

Source sequence(s)

BC062812

Consensus CDS

CCDS21084.1

UniProtKB/Swiss-Prot

P60898

UniProtKB/TrEMBL

A0A6P5PUH6

Related

ENSMUSP00000019882.10, ENSMUST00000019882.16

Conserved Domains (2) summary

COG1594
Location:14 → 125

RPB9; DNA-directed RNA polymerase, subunit M/Transcription elongation factor TFIIS [Transcription]

cd10508
Location:74 → 124

Zn-ribbon_RPB9; C-terminal zinc ribbon domain of RPB9 subunit of RNA polymerase II