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PPP1R11 protein phosphatase 1 regulatory inhibitor subunit 11 [ Homo sapiens (human) ]

Gene ID: 6992, updated on 21-Dec-2019

Summary

Official Symbol
PPP1R11provided by HGNC
Official Full Name
protein phosphatase 1 regulatory inhibitor subunit 11provided by HGNC
Primary source
HGNC:HGNC:9285
See related
Ensembl:ENSG00000204619 MIM:606670
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HCGV; IPP3; HCG-V; TCTE5; TCTEX5; CFAP255
Summary
This gene encodes a specific inhibitor of protein phosphatase-1 (PP1) with a differential sensitivity toward the metal-independent and metal-dependent forms of PP1. The gene is located within the major histocompatibility complex class I region on chromosome 6. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in small intestine (RPKM 46.4), thyroid (RPKM 45.6) and 25 other tissues See more
Orthologs

Genomic context

See PPP1R11 in Genome Data Viewer
Location:
6p22.1
Exon count:
4
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (30066864..30070333)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (30034932..30038110)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene zinc ribbon domain containing 1 antisense, pseudogene Neighboring gene eukaryotic translation termination factor 1 pseudogene 1 Neighboring gene zinc ribbon domain containing 1 Neighboring gene ring finger protein 39 Neighboring gene TRIM31 antisense RNA 1 Neighboring gene tripartite motif containing 31 Neighboring gene tripartite motif containing 40

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies multiple loci influencing human serum metabolite levels.
NHGRI GWA Catalog
Genome-wide association study of proneness to anger.
NHGRI GWA Catalog
Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02).
NHGRI GWA Catalog
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC125741, MGC125742, MGC125743

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase 1 binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine phosphatase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
defense response to Gram-positive bacterium ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cytokine secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of phosphoprotein phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with protein phosphatase type 1 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase PPP1R11
Names
HCG V
hemochromatosis candidate gene V protein
inhibitor-3
protein phosphatase 1 regulatory subunit 11
protein phosphatase 1, regulatory (inhibitor) subunit 11, isoform 1
protein phosphatase inhibitor 3
t-complex-associated-testis-expressed 5
NP_068778.1
XP_006715237.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021959.3NP_068778.1  E3 ubiquitin-protein ligase PPP1R11

    See identical proteins and their annotated locations for NP_068778.1

    Status: REVIEWED

    Source sequence(s)
    AL669914, CB126242
    Consensus CDS
    CCDS4671.1
    UniProtKB/Swiss-Prot
    O60927
    UniProtKB/TrEMBL
    A2BEK1
    Related
    ENSP00000365963.3, ENST00000376772.8
    Conserved Domains (1) summary
    pfam07491
    Location:2971
    PPI_Ypi1; Protein phosphatase inhibitor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    30066864..30070333
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006715174.4XP_006715237.1  E3 ubiquitin-protein ligase PPP1R11 isoform X1

    See identical proteins and their annotated locations for XP_006715237.1

    Conserved Domains (1) summary
    pfam07491
    Location:1860
    PPI_Ypi1; Protein phosphatase inhibitor

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_167244.2 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    1325290..1328425
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_2

Genomic

  1. NT_113891.3 Reference GRCh38.p13 ALT_REF_LOCI_2

    Range
    1546969..1550104
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_3

Genomic

  1. NT_167245.2 Reference GRCh38.p13 ALT_REF_LOCI_3

    Range
    1323114..1326249
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_4

Genomic

  1. NT_167246.2 Reference GRCh38.p13 ALT_REF_LOCI_4

    Range
    1327948..1331083
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_5

Genomic

  1. NT_167247.2 Reference GRCh38.p13 ALT_REF_LOCI_5

    Range
    1411288..1414423
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_6

Genomic

  1. NT_167248.2 Reference GRCh38.p13 ALT_REF_LOCI_6

    Range
    1322358..1325493
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_7

Genomic

  1. NT_167249.2 Reference GRCh38.p13 ALT_REF_LOCI_7

    Range
    1366117..1369252
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_170781.1: Suppressed sequence

    Description
    NM_170781.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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