U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Rasip1 Ras interacting protein 1 [ Mus musculus (house mouse) ]

Gene ID: 69903, updated on 12-May-2024

Summary

Official Symbol
Rasip1provided by MGI
Official Full Name
Ras interacting protein 1provided by MGI
Primary source
MGI:MGI:1917153
See related
Ensembl:ENSMUSG00000044562 AllianceGenome:MGI:1917153
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rain; 1110025D03Rik; 2610025P08Rik
Summary
Predicted to enable protein homodimerization activity and small GTPase binding activity. Involved in regulation of GTPase activity and tube morphogenesis. Predicted to be located in Golgi apparatus and perinuclear region of cytoplasm. Predicted to be part of protein-containing complex. Predicted to be active in cell-cell junction. Is expressed in several structures, including body cavity or lining; cardiovascular system; extraembryonic component; genitourinary system; and vertebral axis musculature. Orthologous to human RASIP1 (Ras interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 76.5), adrenal adult (RPKM 24.9) and 16 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Rasip1 in Genome Data Viewer
Location:
7 B3; 7 29.39 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (45276961..45288516)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45627537..45639092)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene Fgf21 promoter region Neighboring gene fibroblast growth factor 21 Neighboring gene fucosyltransferase 1 Neighboring gene izumo sperm-egg fusion 1 Neighboring gene RIKEN cDNA A030001D20 gene Neighboring gene STARR-positive B cell enhancer mm9_chr7:52899034-52899335 Neighboring gene MEF2 activating motif and SAP domain containing transcriptional regulator Neighboring gene fucosyltransferase 2 Neighboring gene predicted gene, 39008

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC150078

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
involved_in angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in branching morphogenesis of an epithelial tube IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of Rho-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of Rho-dependent protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of membrane permeability ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in positive regulation of integrin activation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of GTPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in vasculogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
PubMed 
is_active_in cell-cell junction IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028544.1NP_082820.1  ras-interacting protein 1

    See identical proteins and their annotated locations for NP_082820.1

    Status: VALIDATED

    Source sequence(s)
    AK033276, BB646451, BC028483, BU054468, CO039349
    Consensus CDS
    CCDS21256.1
    UniProtKB/Swiss-Prot
    E9QLI7, Q3U0S6, Q6GQW4
    UniProtKB/TrEMBL
    B9EK92
    Related
    ENSMUSP00000062429.8, ENSMUST00000057927.10
    Conserved Domains (2) summary
    cd15472
    Location:545911
    Myo5p-like_CBD_Rasip1; cargo binding domain of myosin 5-like of Ras-interacting protein 1
    pfam00788
    Location:141252
    RA; Ras association (RalGDS/AF-6) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    45276961..45288516
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_027253.3: Suppressed sequence

    Description
    NM_027253.3: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.