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cas9 type II CRISPR RNA-guided endonuclease Cas9 [ Streptococcus pyogenes ]

Gene ID: 69900935, updated on 4-Apr-2024

Summary

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Gene symbol
cas9
Gene description
type II CRISPR RNA-guided endonuclease Cas9
Locus tag
DQM35_RS05165
Gene type
protein coding
Organism
Streptococcus pyogenes (strain: NCTC12064, serovar: Lancefield Group A, culture-collection: NCTC:12064)
Lineage
Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae; Streptococcus
Also known as
csn1
Old locus tag
NCTC12064_01025
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Genomic context

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Location:
chromosome: 1

1 - NZ_LS483338.1Genomic Context describing neighboring genes Neighboring gene type II-A CRISPR-associated protein Csn2 Neighboring gene CRISPR-associated endonuclease Cas2 Neighboring gene type II CRISPR-associated endonuclease Cas1 Neighboring gene TIGR01906 family membrane protein Neighboring gene TIGR01457 family HAD-type hydrolase Neighboring gene acyl-[acyl-carrier-protein] thioesterase

Genomic regions, transcripts, and products

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Genomic Sequence:
NZ_LS483338.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. R-loop formation and conformational activation mechanisms of Cas9. Pacesa M, et al. Nature, 2022 Sep. PMID 36002571, Free PMC Article
  2. Probing the Dynamics of Streptococcus pyogenes Cas9 Endonuclease Bound to the sgRNA Complex Using Hydrogen-Deuterium Exchange Mass Spectrometry. Zhdanova PV, et al. Int J Mol Sci, 2022 Jan 20. PMID 35163047, Free PMC Article
  3. A guild of 45 CRISPR-associated (Cas) protein families and multiple CRISPR/Cas subtypes exist in prokaryotic genomes. Haft DH, et al. PLoS Comput Biol, 2005 Nov. PMID 16292354, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. R-loop formation and conformational activation mechanisms of Cas9.
    Title: R-loop formation and conformational activation mechanisms of Cas9.
  2. Probing the Dynamics of Streptococcus pyogenes Cas9 Endonuclease Bound to the sgRNA Complex Using Hydrogen-Deuterium Exchange Mass Spectrometry.
    Title: Probing the Dynamics of Streptococcus pyogenes Cas9 Endonuclease Bound to the sgRNA Complex Using Hydrogen-Deuterium Exchange Mass Spectrometry.
Submit: New GeneRIF Correction

General protein information

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Preferred Names
type II CRISPR RNA-guided endonuclease Cas9
WP_038431314.1
  • Cas9, originally named Csn1, is the large, multifunctional signature protein of type II CRISPR/Cas systems. It is well known even to general audiences because its RNA-guided endonuclease activity has made it a popular tool for custom editing of eukaryotic genomes.

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NZ_LS483338.1 Reference assembly

    Range
    983954..988060 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. WP_038431314.1 type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus pyogenes]

    See identical proteins and their annotated locations for WP_038431314.1

    UniProtKB/TrEMBL
    A0A0H3BZZ0
    Conserved Domains (1) summary
    COG3513
    Location:1 → 1364
    Cas9; CRISPR/Cas system Type II associated protein, contains McrA/HNH and RuvC-like nuclease domains [Defense mechanisms]
Nucleotide Protein
Heading Accession and Version

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