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Tnfaip8l2 tumor necrosis factor, alpha-induced protein 8-like 2 [ Mus musculus (house mouse) ]

Gene ID: 69769, updated on 8-Feb-2024

Summary

Official Symbol
Tnfaip8l2provided by MGI
Official Full Name
tumor necrosis factor, alpha-induced protein 8-like 2provided by MGI
Primary source
MGI:MGI:1917019
See related
Ensembl:ENSMUSG00000013707 AllianceGenome:MGI:1917019
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TIPE2; 1810019A08Rik
Summary
Acts upstream of or within negative regulation of T cell activation and negative regulation of inflammatory response. Located in cytoplasm. Orthologous to human TNFAIP8L2 (TNF alpha induced protein 8 like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in spleen adult (RPKM 43.4), thymus adult (RPKM 22.0) and 13 other tissues See more
Orthologs
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Genomic context

See Tnfaip8l2 in Genome Data Viewer
Location:
3 F2.1; 3 40.74 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (95046832..95051581, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (95139521..95142416, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:94937828-94938011 Neighboring gene sodium channel modifier 1 Neighboring gene LysM, putative peptidoglycan-binding, domain containing 1 Neighboring gene microRNA 8099-1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:94945477-94945712 Neighboring gene predicted gene 9169 Neighboring gene STARR-seq mESC enhancer starr_08369 Neighboring gene sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tumor necrosis factor alpha-induced protein 8-like protein 2
Names
TNF alpha-induced protein 8-like protein 2
TNFAIP8-like protein 2
tumor necrosis factor, alpha-induced protein 8-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027206.3NP_081482.1  tumor necrosis factor alpha-induced protein 8-like protein 2

    See identical proteins and their annotated locations for NP_081482.1

    Status: VALIDATED

    Source sequence(s)
    AC131769
    Consensus CDS
    CCDS17603.1
    UniProtKB/Swiss-Prot
    Q9D8Y7
    Related
    ENSMUSP00000013851.4, ENSMUST00000013851.4
    Conserved Domains (1) summary
    pfam05527
    Location:25177
    DUF758; Domain of unknown function (DUF758)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    95046832..95051581 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006502040.5XP_006502103.1  tumor necrosis factor alpha-induced protein 8-like protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006502103.1

    UniProtKB/Swiss-Prot
    Q9D8Y7
    Conserved Domains (1) summary
    pfam05527
    Location:25177
    DUF758; Domain of unknown function (DUF758)