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TRGV3 T cell receptor gamma variable 3 [ Homo sapiens (human) ]

Gene ID: 6976, updated on 25-Nov-2025
Official Symbol
TRGV3provided by HGNC
Official Full Name
T cell receptor gamma variable 3provided by HGNC
Primary source
HGNC:HGNC:12288
See related
Ensembl:ENSG00000211699 IMGT/GENE-DB:TRGV3; AllianceGenome:HGNC:12288
Gene type
other
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
V1S3; TCRGV3
Summary
Predicted to enable MHC protein binding activity and peptide antigen binding activity. Predicted to be involved in immune response. Predicted to be located in plasma membrane. Predicted to be part of T cell receptor complex. Predicted to be active in external side of plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
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Location:
7p14.1
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (38358512..38358979, complement)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (38515391..38515858, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (38398113..38398580, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene T cell receptor gamma locus Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25867 Neighboring gene TRG antisense RNA 1 Neighboring gene T cell receptor gamma variable 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25868 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25869 Neighboring gene T cell receptor gamma variable 4 Neighboring gene T cell receptor gamma variable 2 Neighboring gene T cell receptor gamma variable 1 (non-functional)

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Human T-cell gamma genes contain N segments and have marked junctional variability. Quertermous T, et al. Nature, 1986 Jul 10-16. PMID 3453106
  2. Cloning and sequence analysis of complementary DNA encoding an aberrantly rearranged human T-cell gamma chain. Dialynas DP, et al. Proc Natl Acad Sci U S A, 1986 Apr. PMID 3458221, Free PMC Article
  3. Diversity and rearrangement of the human T cell rearranging gamma genes: nine germ-line variable genes belonging to two subgroups. LeFranc MP, et al. Cell, 1986 Apr 25. PMID 2938743
  4. Variable region genes in the human T-cell rearranging gamma (TRG) locus: V-J junction and homology with the mouse genes. Huck S, et al. EMBO J, 1988 Mar. PMID 2969332, Free PMC Article
  5. The human T-cell receptor gamma (TRG) genes. Lefranc MP, et al. Trends Biochem Sci, 1989 Jun. PMID 2527426

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Other Names

  • T-cell receptor, gamma, variable region V3

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables MHC protein binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables peptide antigen binding NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in adaptive immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in immune response NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in immune system process IEA
Inferred from Electronic Annotation
more info
  
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of T cell receptor complex IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_001336.3 

    Range
    19662..20129
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    38358512..38358979 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    38515391..38515858 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001013738.1: Suppressed sequence

    Description
    NM_001013738.1: This RefSeq was suppressed because it was provided in error; representation of the rearranged T-cell receptor transcript and protein product is considered out of scope.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P03979.2 GenPept UniProtKB/Swiss-Prot:P03979

Gene LinkOut

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Chemical Information
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Research Materials