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Fbxo7 F-box protein 7 [ Mus musculus (house mouse) ]

Gene ID: 69754, updated on 11-Apr-2024

Summary

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Official Symbol
Fbxo7provided by MGI
Official Full Name
F-box protein 7provided by MGI
Primary source
MGI:MGI:1917004
See related
Ensembl:ENSMUSG00000001786 AllianceGenome:MGI:1917004
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2410015K21Rik; A230052G17Rik
Summary
Enables protein kinase binding activity. Acts upstream of or within negative regulation of G1/S transition of mitotic cell cycle; negative regulation of cyclin-dependent protein serine/threonine kinase activity; and negative regulation of lymphocyte differentiation. Located in mitochondrion and nucleus. Is expressed in dorsal root ganglion; gallbladder; liver; trigeminal ganglion; and vagus ganglion. Human ortholog(s) of this gene implicated in Parkinson's disease and Parkinson's disease 15. Orthologous to human FBXO7 (F-box protein 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 26.7), liver E14.5 (RPKM 23.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 C1; 10 41.91 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (85856313..85887737)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (86020449..86051873)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11450 Neighboring gene predicted gene, 48175 Neighboring gene RNA 2',3'-cyclic phosphate and 5'-OH ligase Neighboring gene BPI fold containing family C Neighboring gene STARR-seq mESC enhancer starr_27455 Neighboring gene STARR-positive B cell enhancer ABC_E8355 Neighboring gene predicted gene, 24430 Neighboring gene RIKEN cDNA 4930486F22 gene Neighboring gene STARR-seq mESC enhancer starr_27456 Neighboring gene predicted gene, 51812 Neighboring gene synapsin III

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Impaired mitochondrial accumulation and Lewy pathology in neuron-specific FBXO7-deficient mice. Noda S, et al. Mol Brain, 2022 Jun 14. PMID 35701754, Free PMC Article
  2. A Conserved Requirement for Fbxo7 During Male Germ Cell Cytoplasmic Remodeling. Rathje CC, et al. Front Physiol, 2019. PMID 31649556, Free PMC Article
  3. Transforming activity of Fbxo7 is mediated specifically through regulation of cyclin D/cdk6. Laman H, et al. EMBO J, 2005 Sep 7. PMID 16096642, Free PMC Article
  4. Myelinating Glia-Specific Deletion of Fbxo7 in Mice Triggers Axonal Degeneration in the Central Nervous System Together with Peripheral Neuropathy. Joseph S, et al. J Neurosci, 2019 Jul 10. PMID 31085610, Free PMC Article
  5. FBXO7 sensitivity of phenotypic traits elucidated by a hypomorphic allele. Ballesteros Reviriego C, et al. PLoS One, 2019. PMID 30840666, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Impaired mitochondrial accumulation and Lewy pathology in neuron-specific FBXO7-deficient mice.
    Title: Impaired mitochondrial accumulation and Lewy pathology in neuron-specific FBXO7-deficient mice.
  2. FBXO7 triggers caspase 8-mediated proteolysis of the transcription factor FOXO4 and exacerbates neuronal cytotoxicity.
    Title: FBXO7 triggers caspase 8-mediated proteolysis of the transcription factor FOXO4 and exacerbates neuronal cytotoxicity.
  3. Chemical inhibition of FBXO7 reduces inflammation and confers neuroprotection by stabilizing the mitochondrial kinase PINK1.
    Title: Chemical inhibition of FBXO7 reduces inflammation and confers neuroprotection by stabilizing the mitochondrial kinase PINK1.
  4. Fbxo7 and Pink1 play a reciprocal role in regulating their protein levels.
    Title: Fbxo7 and Pink1 play a reciprocal role in regulating their protein levels.
  5. Loss of Fbxo7 in myelinating glia led to axonal degeneration in the CNS and peripheral neuropathy.
    Title: Myelinating Glia-Specific Deletion of Fbxo7 in Mice Triggers Axonal Degeneration in the Central Nervous System Together with Peripheral Neuropathy.
  6. The neuroprotective role of FBXO7 involves its suppression of the RPL23-MDM2-p53 axis that promotes cell death in dopaminergic midbrain neurons.
    Title: Loss of FBXO7 results in a Parkinson's-like dopaminergic degeneration via an RPL23-MDM2-TP53 pathway.
  7. Fbxo7 hypomorphs were produced at a normal Mendelian ratio with a normal lifespan and no evidence of neurological symptoms. These data suggest that erythrocyte survival, T cell development and spermatogenesis are particularly sensitive to Fbxo7 gene dosage.
    Title: FBXO7 sensitivity of phenotypic traits elucidated by a hypomorphic allele.
  8. Fbxo7-deficient immature thymocytes failed to undergo expansion in the thymus due to a lack of Cdk6 activity, while mature T cells showed enhanced proliferative capacity upon T-cell receptor engagement due to reduced p27 levels. These studies reveal differential cell cycle regulation by Fbxo7 at different stages in T-cell development.
    Title: Opposing effects on the cell cycle of T lymphocytes by Fbxo7 via Cdk6 and p27.
  9. Taken together, this study establishes a vital role for FBXO7 in neurons, which is required for proper motor control and accentuates the importance of FBXO7 in proteasome function.
    Title: Loss of FBXO7 (PARK15) results in reduced proteasome activity and models a parkinsonism-like phenotype in mice.
  10. Report defective erythropoiesis in transgenic mouse with reduced Fbxo7 expression due to decreased erythrocyte p27 expression.
    Title: Defective erythropoiesis in a mouse model of reduced Fbxo7 expression due to decreased p27 expression.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-like ligase-substrate adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in autophagy of mitochondrion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of lymphocyte differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of lymphocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of cyclin-dependent protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of lymphocyte differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within negative regulation of lymphocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of autophagy of mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of mitophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein targeting to mitochondrion ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of locomotion ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein stability ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Lewy body core ISO
Inferred from Sequence Orthology
more info
  
located_in Lewy body corona ISO
Inferred from Sequence Orthology
more info
  
located_in Lewy neurite ISO
Inferred from Sequence Orthology
more info
  
part_of SCF ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
located_in classical Lewy body ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in glial cytoplasmic inclusion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
part_of ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
F-box only protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310745.1 → NP_001297674.1  F-box only protein 7 isoform 2

    See identical proteins and their annotated locations for NP_001297674.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC122919, AK010499, AK150190
    Consensus CDS
    CCDS78875.1
    UniProtKB/TrEMBL
    Q3UD93
    Related
    ENSMUSP00000113222.2, ENSMUST00000120344.8
    Conserved Domains (3) summary
    pfam06881
    Location:293 → 335
    Elongin_A; RNA polymerase II transcription factor SIII (Elongin) subunit A
    pfam11566
    Location:110 → 243
    PI31_Prot_N; PI31 proteasome regulator N-terminal
    pfam12937
    Location:257 → 300
    F-box-like; F-box-like

  2. NM_001347151.1 → NP_001334080.1  F-box only protein 7 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC122919, AI447461, AK082146, AK147716, AK147907, AK150626
    Consensus CDS
    CCDS83740.1
    UniProtKB/TrEMBL
    Q3UGI9
    Related
    ENSMUSP00000113263.2, ENSMUST00000117597.2
    Conserved Domains (3) summary
    pfam06881
    Location:291 → 333
    Elongin_A; RNA polymerase II transcription factor SIII (Elongin) subunit A
    pfam11566
    Location:112 → 237
    PI31_Prot_N; PI31 proteasome regulator N-terminal
    pfam12937
    Location:255 → 296
    F-box-like

  3. NM_153195.2 → NP_694875.2  F-box only protein 7 isoform 1

    See identical proteins and their annotated locations for NP_694875.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK151025, CD563204
    Consensus CDS
    CCDS24095.1
    UniProtKB/Swiss-Prot
    Q3U7U3, Q3UBC1, Q8K0A5
    Related
    ENSMUSP00000120840.2, ENSMUST00000130320.8
    Conserved Domains (3) summary
    pfam06881
    Location:372 → 414
    Elongin_A; RNA polymerase II transcription factor SIII (Elongin) subunit A
    pfam11566
    Location:189 → 322
    PI31_Prot_N; PI31 proteasome regulator N-terminal
    pfam12937
    Location:336 → 379
    F-box-like; F-box-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    85856313..85887737
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017314077.2 → XP_017169566.1  F-box only protein 7 isoform X1

    Conserved Domains (4) summary
    pfam06881
    Location:340 → 382
    Elongin_A; RNA polymerase II transcription factor SIII (Elongin) subunit A
    pfam11566
    Location:193 → 292
    PI31_Prot_N; PI31 proteasome regulator N-terminal
    pfam12937
    Location:304 → 345
    F-box-like
    cl28922
    Location:1 → 77
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  2. XM_011243556.3 → XP_011241858.1  F-box only protein 7 isoform X2

    See identical proteins and their annotated locations for XP_011241858.1

    Conserved Domains (3) summary
    pfam06881
    Location:234 → 276
    Elongin_A; RNA polymerase II transcription factor SIII (Elongin) subunit A
    pfam11566
    Location:55 → 180
    PI31_Prot_N; PI31 proteasome regulator N-terminal
    pfam12937
    Location:198 → 239
    F-box-like
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3U7U3.2 GenPept UniProtKB/Swiss-Prot:Q3U7U3

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