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TOP1 DNA topoisomerase I [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 697300, updated on 6-Aug-2017

Summary

Gene symbol
TOP1
Gene description
DNA topoisomerase I
See related
Ensembl:ENSMMUG00000011112
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs

Genomic context

See TOP1 in Genome Data Viewer
Location:
chromosome: 10
Exon count:
22
Annotation release Status Assembly Chr Location
102 current Mmul_8.0.1 (GCF_000772875.2) 10 NC_027902.1 (22759812..22863150, complement)
Build 1.2 previous assembly Mmul_051212 (GCF_000002255.3) 10 NC_007867.1 (23332455..23427659, complement)

Chromosome 10 - NC_027902.1Genomic Context describing neighboring genes Neighboring gene zinc fingers and homeoboxes 3 Neighboring gene phospholipase C gamma 1 Neighboring gene uncharacterized LOC107000402 Neighboring gene MAF bZIP transcription factor B

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

General gene information

Markers

Homology

General protein information

Preferred Names
DNA topoisomerase 1
Names
topoisomerase (DNA) I
NP_001253441.1
XP_015004477.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001266512.2NP_001253441.1  DNA topoisomerase 1

    See identical proteins and their annotated locations for NP_001253441.1

    Status: PROVISIONAL

    Source sequence(s)
    JV048105
    UniProtKB/TrEMBL
    H9FZ51
    Related
    ENSMMUP00000014547.3, ENSMMUT00000015533.3
    Conserved Domains (4) summary
    smart00435
    Location:362739
    TOPEUc; DNA Topoisomerase I (eukaryota)
    cd03488
    Location:218432
    Topoisomer_IB_N_htopoI_like; Topoisomer_IB_N_htopoI_like : N-terminal DNA binding fragment found in eukaryotic DNA topoisomerase (topo) IB proteins similar to the monomeric yeast and human topo I. Topo I enzymes are divided into: topo type IA (bacterial) and type IB (eukaryotic). ...
    pfam01028
    Location:434637
    Topoisom_I; Eukaryotic DNA topoisomerase I, catalytic core
    pfam14370
    Location:697765
    Topo_C_assoc; C-terminal topoisomerase domain

RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_8.0.1 Primary Assembly

Genomic

  1. NC_027902.1 Reference Mmul_8.0.1 Primary Assembly

    Range
    22759812..22863150 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015148991.1XP_015004477.1  DNA topoisomerase 1 isoform X1

    UniProtKB/TrEMBL
    H9FZ51
    Related
    ENSMMUP00000047527.1, ENSMMUT00000055431.1
    Conserved Domains (4) summary
    smart00435
    Location:362739
    TOPEUc; DNA Topoisomerase I (eukaryota)
    cd03488
    Location:218432
    Topoisomer_IB_N_htopoI_like; Topoisomer_IB_N_htopoI_like : N-terminal DNA binding fragment found in eukaryotic DNA topoisomerase (topo) IB proteins similar to the monomeric yeast and human topo I. Topo I enzymes are divided into: topo type IA (bacterial) and type IB (eukaryotic). ...
    pfam01028
    Location:434637
    Topoisom_I; Eukaryotic DNA topoisomerase I, catalytic core
    pfam14370
    Location:697765
    Topo_C_assoc; C-terminal topoisomerase domain
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