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Ipmk inositol polyphosphate multikinase [ Mus musculus (house mouse) ]

Gene ID: 69718, updated on 21-Apr-2024

Summary

Official Symbol
Ipmkprovided by MGI
Official Full Name
inositol polyphosphate multikinaseprovided by MGI
Primary source
MGI:MGI:1916968
See related
Ensembl:ENSMUSG00000060733 AllianceGenome:MGI:1916968
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Impk; 2410017C19Rik
Summary
Enables inositol tetrakisphosphate 3-kinase activity and inositol-1,4,5-trisphosphate 3-kinase activity. Acts upstream of or within inositol phosphate biosynthetic process and neural tube formation. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including branchial arch; hindlimb ridge; nervous system; retina nuclear layer; and trunk somite. Orthologous to human IPMK (inositol polyphosphate multikinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in small intestine adult (RPKM 30.9), colon adult (RPKM 26.8) and 27 other tissues See more
Orthologs
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Genomic context

Location:
10 B5.3; 10 36.89 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (71183574..71221715)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (71347744..71385885)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L19, pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_27109 Neighboring gene CDGSH iron sulfur domain 1 Neighboring gene STARR-seq mESC enhancer starr_27110 Neighboring gene STARR-seq mESC enhancer starr_27111 Neighboring gene STARR-seq mESC enhancer starr_27112 Neighboring gene proteolipid protein 2 pseudogene Neighboring gene predicted gene, 34486

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables flavonoid binding ISO
Inferred from Sequence Orthology
more info
 
enables inositol tetrakisphosphate 3-kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables inositol tetrakisphosphate 3-kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables inositol tetrakisphosphate 5-kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables inositol tetrakisphosphate 6-kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables inositol tetrakisphosphate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables inositol-1,4,5-trisphosphate 3-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables inositol-1,4,5-trisphosphate 3-kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables inositol-1,4,5-trisphosphate 3-kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables inositol-1,4,5-trisphosphate 6-kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables myo-inositol-1,2,3,4,6-heptakisphosphate 5-kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in inositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within inositol phosphate biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in inositol trisphosphate metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in necroptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neural tube formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
inositol polyphosphate multikinase
Names
inositol 1,3,4,6-tetrakisphosphate 5-kinase
NP_001334120.1
NP_081460.1
XP_011241857.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347191.2NP_001334120.1  inositol polyphosphate multikinase isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (2) has the same N- and C-termini, but is one aa longer than isoform 1.
    Source sequence(s)
    AC156270
    Consensus CDS
    CCDS83711.1
    UniProtKB/TrEMBL
    D3YWA2
    Related
    ENSMUSP00000112568.2, ENSMUST00000121446.2
  2. NM_027184.3NP_081460.1  inositol polyphosphate multikinase isoform 1

    See identical proteins and their annotated locations for NP_081460.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the shorter isoform (1).
    Source sequence(s)
    AC156270
    Consensus CDS
    CCDS23918.1
    UniProtKB/Swiss-Prot
    Q7TT16, Q8BZ11, Q8BZA8, Q9CWM9
    Related
    ENSMUSP00000078240.7, ENSMUST00000079252.13
    Conserved Domains (1) summary
    pfam03770
    Location:110391
    IPK; Inositol polyphosphate kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    71183574..71221715
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011243555.2XP_011241857.1  inositol polyphosphate multikinase isoform X1

    Conserved Domains (1) summary
    cl12283
    Location:111194
    IPK; Inositol polyphosphate kinase