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Col22a1 collagen, type XXII, alpha 1 [ Mus musculus (house mouse) ]

Gene ID: 69700, updated on 30-Apr-2024

Summary

Official Symbol
Col22a1provided by MGI
Official Full Name
collagen, type XXII, alpha 1provided by MGI
Primary source
MGI:MGI:1916950
See related
Ensembl:ENSMUSG00000079022 AllianceGenome:MGI:1916950
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2310067L16Rik
Summary
Predicted to be an extracellular matrix structural constituent. Predicted to be involved in angiogenesis; endothelial cell morphogenesis; and extracellular matrix organization. Located in collagen-containing extracellular matrix. Is expressed in central nervous system and neural retina. Human ortholog(s) of this gene implicated in intracranial aneurysm. Orthologous to human COL22A1 (collagen type XXII alpha 1 chain). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 11.9), limb E14.5 (RPKM 2.3) and 4 other tissues See more
Orthologs
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Genomic context

See Col22a1 in Genome Data Viewer
Location:
15 D3; 15 32.31 cM
Exon count:
67
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (71667644..71906087, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (71795795..72150979, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 22519 Neighboring gene eukaryotic translation initiation factor 4A2 pseudogene Neighboring gene predicted gene 16308 Neighboring gene STARR-positive B cell enhancer mm9_chr15:71748108-71748408 Neighboring gene STARR-seq mESC enhancer starr_38924 Neighboring gene STARR-seq mESC enhancer starr_38925 Neighboring gene STARR-seq mESC enhancer starr_38926 Neighboring gene STARR-seq mESC enhancer starr_38927 Neighboring gene predicted gene, 23217 Neighboring gene STARR-seq mESC enhancer starr_38928 Neighboring gene STARR-seq mESC enhancer starr_38929 Neighboring gene STARR-seq mESC enhancer starr_38930 Neighboring gene STARR-seq mESC enhancer starr_38931 Neighboring gene STARR-seq mESC enhancer starr_38932 Neighboring gene predicted gene, 52221

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (6) 

General protein information

Preferred Names
collagen alpha-1(XXII) chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027174.1NP_081450.1  collagen alpha-1(XXII) chain precursor

    See identical proteins and their annotated locations for NP_081450.1

    Status: VALIDATED

    Source sequence(s)
    AC123689, AC157602, AC168214
    Consensus CDS
    CCDS49627.1
    UniProtKB/TrEMBL
    E9Q7P1
    Related
    ENSMUSP00000125069.2, ENSMUST00000159993.8
    Conserved Domains (3) summary
    pfam01391
    Location:760817
    Collagen; Collagen triple helix repeat (20 copies)
    cl00057
    Location:47228
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    cl22861
    Location:248435
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    71667644..71906087 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521381.4XP_006521444.1  collagen alpha-1(XXII) chain isoform X2

    See identical proteins and their annotated locations for XP_006521444.1

    UniProtKB/TrEMBL
    E9Q7P1
    Conserved Domains (3) summary
    pfam01391
    Location:760817
    Collagen; Collagen triple helix repeat (20 copies)
    cl00057
    Location:47228
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    cl22861
    Location:248435
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
  2. XM_036159577.1XP_036015470.1  collagen alpha-1(XXII) chain isoform X1

    Conserved Domains (3) summary
    pfam01391
    Location:779833
    Collagen; Collagen triple helix repeat (20 copies)
    cl00057
    Location:63244
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    cl22861
    Location:264451
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
  3. XM_006521383.2XP_006521446.1  collagen alpha-1(XXII) chain isoform X3

    UniProtKB/TrEMBL
    A0A2R8W6Z9
    Related
    ENSMUSP00000155641.2, ENSMUST00000229585.2
    Conserved Domains (1) summary
    pfam01391
    Location:205262
    Collagen; Collagen triple helix repeat (20 copies)