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Col22a1 collagen, type XXII, alpha 1 [ Mus musculus (house mouse) ]

Gene ID: 69700, updated on 21-Mar-2023

Summary

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Official Symbol
Col22a1provided by MGI
Official Full Name
collagen, type XXII, alpha 1provided by MGI
Primary source
MGI:MGI:1916950
See related
Ensembl:ENSMUSG00000079022 AllianceGenome:MGI:1916950
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2310067L16Rik
Summary
Predicted to be an extracellular matrix structural constituent. Predicted to be involved in angiogenesis; endothelial cell morphogenesis; and extracellular matrix organization. Located in collagen-containing extracellular matrix. Is expressed in central nervous system and neural retina. Human ortholog(s) of this gene implicated in intracranial aneurysm. Orthologous to human COL22A1 (collagen type XXII alpha 1 chain). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 11.9), limb E14.5 (RPKM 2.3) and 4 other tissues See more
Orthologs
human all
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Genomic context

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See Col22a1 in Genome Data Viewer
Location:
15; 15 D3
Exon count:
67
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (71667644..71906087, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (71795795..72150979, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 22519 Neighboring gene eukaryotic translation initiation factor 4A2 pseudogene Neighboring gene predicted gene, 23217 Neighboring gene predicted gene, 52221

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Decreased Trabecular Bone Mass in Col22a1-Deficient Mice. Zhao W, et al. Cells, 2021 Nov 4. PMID 34831244, Free PMC Article
  2. Polycomb EZH2 controls self-renewal and safeguards the transcriptional identity of skeletal muscle stem cells. Juan AH, et al. Genes Dev, 2011 Apr 15. PMID 21498568, Free PMC Article
  3. Mechanical loading is required for initiation of extracellular matrix deposition at the developing murine myotendinous junction. Lipp SN, et al. Matrix Biol, 2023 Feb. PMID 36709857
  4. Integrated Transcriptome and Network Analysis Reveals Spatiotemporal Dynamics of Calvarial Suturogenesis. Holmes G, et al. Cell Rep, 2020 Jul 7. PMID 32640236, Free PMC Article
  5. Osteoblast-specific expression of Panx3 is dispensable for postnatal bone remodeling. Yorgan TA, et al. Bone, 2019 Oct. PMID 31202927

See all (19) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Decreased Trabecular Bone Mass in Col22a1-Deficient Mice.
    Title: Decreased Trabecular Bone Mass in Col22a1-Deficient Mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables extracellular matrix structural constituent IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables extracellular matrix structural constituent conferring tensile strength RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix HDA PubMed 
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 

General protein information

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Preferred Names
collagen alpha-1(XXII) chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027174.1 → NP_081450.1  collagen alpha-1(XXII) chain precursor

    See identical proteins and their annotated locations for NP_081450.1

    Status: VALIDATED

    Source sequence(s)
    AC123689, AC157602, AC168214
    Consensus CDS
    CCDS49627.1
    UniProtKB/TrEMBL
    E9Q7P1
    Related
    ENSMUSP00000125069.2, ENSMUST00000159993.8
    Conserved Domains (3) summary
    pfam01391
    Location:760 → 817
    Collagen; Collagen triple helix repeat (20 copies)
    cl00057
    Location:47 → 228
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    cl22861
    Location:248 → 435
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    71667644..71906087 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521381.4 → XP_006521444.1  collagen alpha-1(XXII) chain isoform X2

    See identical proteins and their annotated locations for XP_006521444.1

    UniProtKB/TrEMBL
    E9Q7P1
    Conserved Domains (3) summary
    pfam01391
    Location:760 → 817
    Collagen; Collagen triple helix repeat (20 copies)
    cl00057
    Location:47 → 228
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    cl22861
    Location:248 → 435
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

  2. XM_036159577.1 → XP_036015470.1  collagen alpha-1(XXII) chain isoform X1

    Conserved Domains (3) summary
    pfam01391
    Location:779 → 833
    Collagen; Collagen triple helix repeat (20 copies)
    cl00057
    Location:63 → 244
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    cl22861
    Location:264 → 451
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

  3. XM_006521383.2 → XP_006521446.1  collagen alpha-1(XXII) chain isoform X3

    UniProtKB/TrEMBL
    A0A2R8W6Z9
    Related
    ENSMUSP00000155641.2, ENSMUST00000229585.2
    Conserved Domains (1) summary
    pfam01391
    Location:205 → 262
    Collagen; Collagen triple helix repeat (20 copies)
Nucleotide Protein Strain
Heading Accession and Version

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