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Pir pirin [ Mus musculus (house mouse) ]

Gene ID: 69656, updated on 2-Oct-2018

Summary

Official Symbol
Pirprovided by MGI
Official Full Name
pirinprovided by MGI
Primary source
MGI:MGI:1916906
See related
Ensembl:ENSMUSG00000031379 Vega:OTTMUSG00000019513
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pirnl; 2310042L19Rik
Expression
Broad expression in bladder adult (RPKM 6.3), liver E14 (RPKM 3.9) and 20 other tissues See more
Orthologs

Genomic context

See Pir in Genome Data Viewer
Location:
X; X F5
Exon count:
10
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) X NC_000086.7 (164269431..164373013)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (160707363..160810945)

Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Neighboring gene BMX non-receptor tyrosine kinase Neighboring gene predicted gene, 19251 Neighboring gene 40S ribosomal protein S29 pseudogene Neighboring gene vascular endothelial growth factor D Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class A Neighboring gene ankyrin repeat and SOCS box-containing 11

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
dioxygenase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding ISO
Inferred from Sequence Orthology
more info
 
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
quercetin 2,3-dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
quercetin 2,3-dioxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
quercetin 2,3-dioxygenase activity ISO
Inferred from Sequence Orthology
more info
 
transcription coregulator activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
monocyte differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
monocyte differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
myeloid cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
pirin
Names
iron-binding nuclear protein
pirin like
probable quercetin 2,3-dioxygenase PIR
probable quercetinase
NP_001288331.1
NP_081429.1
XP_006529040.1
XP_006529041.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301402.1NP_001288331.1  pirin isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an internal exon in the 5' region, which results in translation initiation at a downstream in-frame start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AL671706, AL732475
    Conserved Domains (3) summary
    COG1741
    Location:1203
    YhaK; Redox-sensitive bicupin YhaK, pirin superfamily [General function prediction only]
    pfam05726
    Location:99205
    Pirin_C; Pirin C-terminal cupin domain
    cl21464
    Location:146
    cupin_like; Conserved domain found in cupin and related proteins
  2. NM_027153.3NP_081429.1  pirin isoform 1

    See identical proteins and their annotated locations for NP_081429.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK009757, AL732475, BY718294
    Consensus CDS
    CCDS30520.1
    UniProtKB/Swiss-Prot
    Q9D711
    Related
    ENSMUSP00000033749.7, OTTMUSP00000021043, ENSMUST00000033749.8, OTTMUST00000046597
    Conserved Domains (3) summary
    COG1741
    Location:17275
    YhaK; Redox-sensitive bicupin YhaK, pirin superfamily [General function prediction only]
    pfam02678
    Location:21118
    Pirin; Pirin
    pfam05726
    Location:171277
    Pirin_C; Pirin C-terminal cupin domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000086.7 Reference GRCm38.p4 C57BL/6J

    Range
    164269431..164373013
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006528978.3XP_006529041.1  pirin isoform X2

    Conserved Domains (3) summary
    COG1741
    Location:17260
    YhaK; Redox-sensitive bicupin YhaK, pirin superfamily [General function prediction only]
    pfam02678
    Location:21118
    Pirin; Pirin
    pfam05726
    Location:171262
    Pirin_C; Pirin C-terminal cupin domain
  2. XM_006528977.3XP_006529040.1  pirin isoform X1

    See identical proteins and their annotated locations for XP_006529040.1

    UniProtKB/Swiss-Prot
    Q9D711
    Related
    ENSMUSP00000118045.1, OTTMUSP00000021044, ENSMUST00000145412.7, OTTMUST00000046600
    Conserved Domains (3) summary
    COG1741
    Location:17275
    YhaK; Redox-sensitive bicupin YhaK, pirin superfamily [General function prediction only]
    pfam02678
    Location:21118
    Pirin; Pirin
    pfam05726
    Location:171277
    Pirin_C; Pirin C-terminal cupin domain
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