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TRG T cell receptor gamma locus [ Homo sapiens (human) ]

Gene ID: 6965, updated on 23-Nov-2021

Summary

Official Symbol
TRGprovided by HGNC
Official Full Name
T cell receptor gamma locusprovided by HGNC
Primary source
HGNC:HGNC:12271
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TCRG; TRG@
Summary
T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor gamma locus. The gamma locus includes V (variable), J (joining), and C (constant) segments. During T cell development, the gamma chain is synthesized by a recombination event at the DNA level joining a V segment with a J segment; the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random addition of nucleotides by terminal deoxynucleotidyltransferase. Several V segments of the gamma locus are known to be incapable of encoding a protein and are considered pseudogenes. Somatic rearrangement of the gamma locus has been observed in T cells derived from patients with T cell leukemia and ataxia telangiectasia. [provided by RefSeq, Jul 2008]
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Genomic context

See TRG in Genome Data Viewer
Location:
7p14.1
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (38240024..38368055, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (38279625..38407656, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375236 Neighboring gene STARD3 N-terminal like Neighboring gene uncharacterized LOC107986784 Neighboring gene T cell receptor gamma constant 2 Neighboring gene T cell receptor gamma joining P2 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 10 pseudogene Neighboring gene T cell receptor gamma joining 2 Neighboring gene T cell receptor gamma constant 1 Neighboring gene T cell receptor gamma joining P1 Neighboring gene T cell receptor gamma joining 1 Neighboring gene TCR gamma alternate reading frame protein Neighboring gene T cell receptor gamma joining P Neighboring gene T cell receptor gamma variable 11 (non-functional) Neighboring gene T cell receptor gamma variable 10 (non-functional) Neighboring gene T cell receptor gamma variable B (pseudogene) Neighboring gene T cell receptor gamma variable 9 Neighboring gene T cell receptor gamma variable A (pseudogene) Neighboring gene T cell receptor gamma locus antisense RNA 1 Neighboring gene T cell receptor gamma variable 8 Neighboring gene T cell receptor gamma variable 7 (pseudogene) Neighboring gene T cell receptor gamma variable 5P (pseudogene) Neighboring gene T cell receptor gamma variable 6 (pseudogene) Neighboring gene T cell receptor gamma variable 5 Neighboring gene T cell receptor gamma variable 4 Neighboring gene T cell receptor gamma variable 3 Neighboring gene T cell receptor gamma variable 2 Neighboring gene T cell receptor gamma variable 1 (non-functional) Neighboring gene amphiphysin Neighboring gene RNA, 7SL, cytoplasmic 83, pseudogene Neighboring gene keratin 8 pseudogene 20

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Other Names

  • T-cell antigen receptor, gamma polypeptide
  • T-cell rearranging gene, gamma
  • T-cell receptor, gamma cluster
  • TCRG, TRG@

General protein information

Names
T cell receptor gamma locus
T-cell antigen receptor, gamma polypeptide
T-cell rearranging gene, gamma
T-cell receptor, gamma cluster
TCRG, TRG@

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_001336.2 

    Range
    5893..133924
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    38240024..38368055 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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