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LEF1 lymphoid enhancer binding factor 1 [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 695776, updated on 10-Feb-2026
Official Symbol
LEF1provided by VGNC
Official Full Name
lymphoid enhancer binding factor 1provided by VGNC
Primary source
VGNC:VGNC:74251
See related
Ensembl:ENSMMUG00000023256
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
all
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Try the new Transcripts and proteins table
See LEF1 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2025_08 current T2T-MMU8v2.0 (GCF_049350105.2) 5 NC_133410.1 (117359677..117482464, complement)
103 previous assembly Mmul_10 (GCF_003339765.1) 5 NC_041758.1 (106411810..106535836, complement)

Chromosome 5 - NC_133410.1Genomic Context describing neighboring genes Neighboring gene large ribosomal subunit protein eL37 Neighboring gene hydroxyacyl-CoA dehydrogenase Neighboring gene uncharacterized LOC114678377 Neighboring gene uncharacterized LOC114678172 Neighboring gene large ribosomal subunit protein uL24

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of beta-catenin-TCF complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in chromatin IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
lymphoid enhancer-binding factor 1

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: GCF_049350105.2-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference T2T-MMU8v2.0

Genomic

  1. NC_133410.1 Reference T2T-MMU8v2.0

    Range
    117359677..117482464 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001086645.5 → XP_001086645.2  lymphoid enhancer-binding factor 1 isoform X3

    See identical proteins and their annotated locations for XP_001086645.2

    UniProtKB/TrEMBL
    F7HPX5
    Conserved Domains (2) summary
    cd01388
    Location:270 → 341
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:1 → 213
    CTNNB1_binding; N-terminal CTNNB1 binding

  2. XM_015138983.3 → XP_014994469.1  lymphoid enhancer-binding factor 1 isoform X4

    UniProtKB/TrEMBL
    F7HPX5
    Related
    ENSMMUP00000034904.3
    Conserved Domains (2) summary
    cd01388
    Location:270 → 341
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:1 → 213
    CTNNB1_binding; N-terminal CTNNB1 binding

  3. XM_015138981.3 → XP_014994467.1  lymphoid enhancer-binding factor 1 isoform X1

    UniProtKB/TrEMBL
    A0A1D5Q829, G7MTL3
    Related
    ENSMMUP00000044196.2
    Conserved Domains (2) summary
    cd01388
    Location:298 → 369
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:1 → 213
    CTNNB1_binding; N-terminal CTNNB1 binding

  4. XM_015138982.3 → XP_014994468.1  lymphoid enhancer-binding factor 1 isoform X2

    UniProtKB/TrEMBL
    G7MTL3
    Related
    ENSMMUP00000058770.2
    Conserved Domains (2) summary
    cd01388
    Location:298 → 369
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:1 → 213
    CTNNB1_binding; N-terminal CTNNB1 binding

  5. XM_015138984.3 → XP_014994470.1  lymphoid enhancer-binding factor 1 isoform X5

    UniProtKB/TrEMBL
    A0A1D5REM7
    Conserved Domains (2) summary
    cd01388
    Location:230 → 301
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:6 → 145
    CTNNB1_binding; N-terminal CTNNB1 binding

  6. XM_078002077.1 → XP_077858203.1  lymphoid enhancer-binding factor 1 isoform X6

    UniProtKB/TrEMBL
    A0A1D5REM7

  7. XM_015138985.3 → XP_014994471.1  lymphoid enhancer-binding factor 1 isoform X7

    UniProtKB/TrEMBL
    F7HPX5
    Conserved Domains (2) summary
    cd01388
    Location:202 → 273
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:6 → 145
    CTNNB1_binding; N-terminal CTNNB1 binding
Nucleotide Protein
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