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Hilpda hypoxia inducible lipid droplet associated [ Mus musculus (house mouse) ]

Gene ID: 69573, updated on 12-May-2024

Summary

Official Symbol
Hilpdaprovided by MGI
Official Full Name
hypoxia inducible lipid droplet associatedprovided by MGI
Primary source
MGI:MGI:1916823
See related
Ensembl:ENSMUSG00000043421 AllianceGenome:MGI:1916823
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hig2; 2310016C08Rik
Summary
Predicted to enable signaling receptor binding activity. Predicted to be involved in several processes, including autocrine signaling; positive regulation of cytokine production; and positive regulation of lipid storage. Predicted to be located in several cellular components, including cell surface; nucleoplasm; and secretory granule. Predicted to be active in lipid droplet. Orthologous to human HILPDA (hypoxia inducible lipid droplet associated). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 46.4), liver E18 (RPKM 18.6) and 23 other tissues See more
Orthologs
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Genomic context

See Hilpda in Genome Data Viewer
Location:
6 A3.3; 6 12.36 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (29272487..29275448)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (29272488..29275449)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26021 Neighboring gene predicted gene, 40358 Neighboring gene STARR-positive B cell enhancer ABC_E4814 Neighboring gene golgi associated RAB2 interactor 1A Neighboring gene STARR-seq mESC enhancer starr_15437 Neighboring gene golgi associated RAB2 interactor 1B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Targeted (2)  1 citation

Pathways from PubChem

General gene information

Markers

Clone Names

  • MGC103106

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in autocrine signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in autocrine signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytokine production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of lipid storage ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
is_active_in lipid droplet IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in lipid droplet ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in secretory granule ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
hypoxia-inducible lipid droplet-associated protein
Names
hypoxia-inducible gene 2 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190461.1NP_001177390.1  hypoxia-inducible lipid droplet-associated protein isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC079277
    Conserved Domains (1) summary
    pfam15220
    Location:3294
    HILPDA; Hypoxia-inducible lipid droplet-associated
  2. NM_023516.5NP_076005.1  hypoxia-inducible lipid droplet-associated protein isoform 2

    See identical proteins and their annotated locations for NP_076005.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' exon and uses a downstream start codon, compared to variant 1. Isoform 2 has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK009377, AW538932, BY113188
    Consensus CDS
    CCDS39450.1
    UniProtKB/Swiss-Prot
    Q3UMU3, Q8VDY1, Q9JLS0
    Related
    ENSMUSP00000060791.9, ENSMUST00000054445.9
    Conserved Domains (1) summary
    pfam15220
    Location:163
    HILPDA; Hypoxia-inducible lipid droplet-associated

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    29272487..29275448
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)