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TRB T cell receptor beta locus [ Homo sapiens (human) ]

Gene ID: 6957, updated on 11-Jun-2021

Summary

Official Symbol
TRBprovided by HGNC
Official Full Name
T cell receptor beta locusprovided by HGNC
Primary source
HGNC:HGNC:12155
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TCRB; TRB@
Summary
T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor beta locus. The beta locus includes V (variable), J (joining), diversity (D), and C (constant) segments. During T cell development, the beta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Several V segments and one J segment of the beta locus are known to be incapable of encoding a protein and are considered pseudogenes. The beta locus also includes eight trypsinogen genes, three of which encode functional proteins and five of which are pseudogenes. Chromosomal abnormalities involving the T-cell receptor beta locus have been associated with T-cell lymphomas. [provided by RefSeq, Jul 2008]
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Genomic context

See TRB in Genome Data Viewer
Location:
7q34
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (142299011..142813287)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (141998851..142510972)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 9540 Neighboring gene uncharacterized LOC105375539 Neighboring gene PRSS3 pseudogene 3 Neighboring gene T cell receptor beta variable 3-1 Neighboring gene T cell receptor beta variable 4-1 Neighboring gene T cell receptor beta variable 1 (pseudogene) Neighboring gene T cell receptor beta variable 2 Neighboring gene T cell receptor beta variable 5-1 Neighboring gene T cell receptor beta variable 6-1 Neighboring gene T cell receptor beta variable 7-1 (non-functional) Neighboring gene T cell receptor beta variable 4-2 Neighboring gene T cell receptor beta variable 6-3 Neighboring gene T cell receptor beta variable 7-2 Neighboring gene T cell receptor beta variable 8-1 (pseudogene) Neighboring gene T cell receptor beta variable 5-2 (pseudogene) Neighboring gene T cell receptor beta variable 6-4 Neighboring gene T cell receptor beta variable 7-3 Neighboring gene T cell receptor beta variable 8-2 (pseudogene) Neighboring gene T cell receptor beta variable 5-3 (non-functional) Neighboring gene T cell receptor beta variable 10-1 Neighboring gene T cell receptor beta variable 11-1 Neighboring gene T cell receptor beta variable 9 Neighboring gene T cell receptor beta variable 12-1 (pseudogene) Neighboring gene T cell receptor beta variable 10-2 Neighboring gene uncharacterized LOC107986855 Neighboring gene T cell receptor beta variable 11-2 Neighboring gene uncharacterized LOC105379749 Neighboring gene T cell receptor beta variable 12-2 (pseudogene) Neighboring gene T cell receptor beta variable 6-5 Neighboring gene T cell receptor beta variable 7-4 Neighboring gene T cell receptor beta variable 5-4 Neighboring gene microRNA 11400 Neighboring gene T cell receptor beta variable 6-6 Neighboring gene T cell receptor beta variable 7-5 (pseudogene) Neighboring gene T cell receptor beta variable 5-5 Neighboring gene T cell receptor beta variable 6-7 (non-functional) Neighboring gene T cell receptor beta variable 7-6 Neighboring gene T cell receptor beta variable 5-6 Neighboring gene T cell receptor beta variable 6-8 Neighboring gene T cell receptor beta variable 7-7 Neighboring gene T cell receptor beta variable 5-7 (non-functional) Neighboring gene T cell receptor beta variable 7-9 Neighboring gene T cell receptor beta variable 10-3 Neighboring gene T cell receptor beta variable 13 Neighboring gene T cell receptor beta variable 11-3 Neighboring gene T cell receptor beta variable 12-3 Neighboring gene T cell receptor beta variable 12-4 Neighboring gene T cell receptor beta variable 12-5 Neighboring gene Sharpr-MPRA regulatory region 1556/5446 Neighboring gene T cell receptor beta variable 14 Neighboring gene T cell receptor beta variable 15 Neighboring gene T cell receptor beta variable 16 Neighboring gene T cell receptor beta variable 17 (non-functional) Neighboring gene T cell receptor beta variable 20-1 Neighboring gene T cell receptor beta variable 18 Neighboring gene T cell receptor beta variable 19 Neighboring gene T cell receptor beta variable 21-1 (pseudogene) Neighboring gene T cell receptor beta variable 22-1 (pseudogene) Neighboring gene T cell receptor beta variable 23-1 (non-functional) Neighboring gene T cell receptor beta variable 24-1 Neighboring gene MT-RNR2 like 6 Neighboring gene T cell receptor beta variable 25-1 Neighboring gene T cell receptor beta variable A (pseudogene) Neighboring gene T cell receptor beta variable 26 (pseudogene) Neighboring gene T cell receptor beta variable 27 Neighboring gene piggyBac transposable element derived 4 pseudogene 1 Neighboring gene T cell receptor beta variable B (pseudogene) Neighboring gene T cell receptor beta variable 28 Neighboring gene T cell receptor beta variable 29-1 Neighboring gene serine protease 1 Neighboring gene PRSS3 pseudogene 1 Neighboring gene CRISPRi-validated cis-regulatory element chr7.5162 Neighboring gene CRISPRi-validated cis-regulatory element chr7.5163 Neighboring gene uncharacterized LOC105375541 Neighboring gene WBP1L pseudogene 1 Neighboring gene T cell receptor beta joining 1-3 Neighboring gene T cell receptor beta joining 1-2 Neighboring gene serine protease 2 Neighboring gene T cell receptor beta joining 1-1 Neighboring gene CRISPRi-validated cis-regulatory element chr7.5168 Neighboring gene T cell receptor beta joining 2-2P (non-functional) Neighboring gene T cell receptor beta joining 1-6 Neighboring gene T cell receptor beta joining 1-5 Neighboring gene T cell receptor beta joining 1-4 Neighboring gene T cell receptor beta joining 2-1 Neighboring gene T cell receptor beta joining 2-2 Neighboring gene T cell receptor beta joining 2-3 Neighboring gene T cell receptor beta joining 2-4 Neighboring gene T cell receptor beta joining 2-5 Neighboring gene T cell receptor beta joining 2-6 Neighboring gene T cell receptor beta joining 2-7 Neighboring gene T cell receptor beta diversity 1 Neighboring gene T cell receptor beta constant 1 Neighboring gene T cell receptor beta diversity 2 Neighboring gene T cell receptor beta constant 2 Neighboring gene T cell receptor beta variable 30

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome wide analysis of narcolepsy in China implicates novel immune loci and reveals changes in association prior to versus after the 2009 H1N1 influenza pandemic.
GeneReviews: Not available
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Other Names

  • T-cell antigen receptor, beta polypeptide, T-cell receptor, beta cluster
  • T-cell receptor, beta cluster
  • TCRB, TRB@

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables signaling receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of alpha-beta T cell receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Names
T cell receptor beta locus
T-cell antigen receptor, beta polypeptide, T-cell receptor, beta cluster
T-cell receptor, beta cluster
TCRB, TRB@

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_001333.2 

    Range
    91557..667340
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    142299011..142813287
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187562.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    260931..836260
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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