Vkorc1l1 vitamin K epoxide reductase complex, subunit 1-like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Vkorc1l1provided by MGI
Official Full Name: vitamin K epoxide reductase complex, subunit 1-like 1provided by MGI
Primary source: MGI:MGI:1916818
See related: Ensembl:ENSMUSG00000066735 AllianceGenome:MGI:1916818
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2310024K08Rik
Summary: Enables vitamin-K-epoxide reductase (warfarin-sensitive) activity. Involved in vitamin K metabolic process. Predicted to be located in endoplasmic reticulum membrane. Is expressed in liver. Orthologous to human VKORC1L1 (vitamin K epoxide reductase complex subunit 1 like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in genital fat pad adult (RPKM 7.6), CNS E18 (RPKM 7.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5; 5 G1.3

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (129970950..130015533)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (129942109..129986692)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

VKORC1L1 supports vitamin K-dependent (VKD) protein protein carboxylation in vivo.
Title: VKOR paralog VKORC1L1 supports vitamin K-dependent protein carboxylation in vivo.
Vkorc1l1 promotes adipogenesis and possibly obesity. Downregulation of Vkorc1l1 increases intracellular vitamin K2 level and impedes preadipocyte differentiation.
Title: The Vitamin K Epoxide Reductase Vkorc1l1 Promotes Preadipocyte Differentiation in Mice.
quantified mRNA levels for VKORC1, VKORC1L1, GGCX, and NQO1 and measured VKOR enzymatic activities in 29 different tissues
Title: Two enzymes catalyze vitamin K 2,3-epoxide reductase activity in mouse: VKORC1 is highly expressed in exocrine tissues while VKORC1L1 is highly expressed in brain.
The involvement of VKORC1L1 in VKOR activity partly explains the low susceptibility of some extrahepatic tissues to vitamin K antagonists.
Title: VKORC1L1, an enzyme rescuing the vitamin K 2,3-epoxide reductase activity in some extrahepatic tissues during anticoagulation therapy.
molecular cloning
Title: Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:489243 (e-PCR)
- UniSTS:489243

NoName (e-PCR)
- UniSTS:224592

NoName (e-PCR)
- UniSTS:495064

Homology

Homologs of the Vkorc1l1 gene: The Vkorc1l1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, mosquito, and frog.
Orthologs from Annotation Pipeline: 471 organisms have orthologs with human gene Vkorc1l1
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables quinone binding	IEA Inferred from Electronic Annotation more info
enables vitamin-K-epoxide reductase (warfarin-sensitive) activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables vitamin-K-epoxide reductase (warfarin-sensitive) activity	IDA Inferred from Direct Assay more info	PubMed
enables vitamin-K-epoxide reductase (warfarin-sensitive) activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-glutamic acid carboxylation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in peptidyl-glutamic acid carboxylation	ISO Inferred from Sequence Orthology more info
involved_in vitamin K metabolic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in vitamin K metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within vitamin K metabolic process	ISO Inferred from Sequence Orthology more info
involved_in vitamin K metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: vitamin K epoxide reductase complex subunit 1-like protein 1

Names: VKORC1-like protein 1

NP_001001327.1

EC 1.17.4.4

NP_001273311.1

EC 1.17.4.4

NP_081397.1

EC 1.17.4.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001001327.2 → NP_001001327.1 vitamin K epoxide reductase complex subunit 1-like protein 1 isoform 2

See identical proteins and their annotated locations for NP_001001327.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region, resulting in a frameshift and an early stop codon, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AK033702, AK078942, BC085133, BE954096, CF533903, CK639505, CN457470

Consensus CDS

CCDS19704.1

UniProtKB/TrEMBL

Q0VGU5

Related

ENSMUSP00000144608.2, ENSMUST00000201855.2

Conserved Domains (1) summary

cl01729
Location:18 → 65

VKOR; Vitamin K epoxide reductase (VKOR) family
NM_001286382.1 → NP_001273311.1 vitamin K epoxide reductase complex subunit 1-like protein 1 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 3, which is shorter than isoform 1.

Source sequence(s)

AK033702, AK078942, BC085133, BE954096, CF533903, CK639505, CN457470, CN701203

Consensus CDS

CCDS80417.1

UniProtKB/TrEMBL

A0A0M3HEP8, Q0VGU5

Related

ENSMUSP00000073601.6, ENSMUST00000073945.6

Conserved Domains (1) summary

cd12917
Location:19 → 110

VKOR_euk; Vitamin K epoxide reductase family in eukaryotes, excluding plants
NM_027121.4 → NP_081397.1 vitamin K epoxide reductase complex subunit 1-like protein 1 isoform 1

See identical proteins and their annotated locations for NP_081397.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AK033702, AK078942, BC085133, BE954096, CF533903, CK639505, CN457470, CN701203

Consensus CDS

CCDS19703.1

UniProtKB/Swiss-Prot

Q05AD4, Q6TEK5

UniProtKB/TrEMBL

A0A6P5PV66, Q0VGU5

Related

ENSMUSP00000059139.9, ENSMUST00000051758.11

Conserved Domains (1) summary

cd12917
Location:18 → 156

VKOR_euk; Vitamin K epoxide reductase family in eukaryotes, excluding plants